Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 15, 1996, Pages 1759-1764

  Jagdmann Jr , G Erik ^a   Defauw, Jean M ^a   Lampe, John W ^a   Darges, James W ^a   Kalter, Kiyomi ^a  

^a Sphinx Pharmaceuticals Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BALANOL; BALANOL DERIVATIVE; CYCLOPENTANE DERIVATIVE; ISOENZYME; PRODRUG; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; NEUTROPHIL; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

FUNGI; HAPTOCILLIUM BALANOIDES;

EID: 0030572481     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00311-3     Document Type: Article

References (25)

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25. 6-DMSO. Coupling constants for syn protons were 4-5 Hz, and coupling constants for anti protons were 0.5-1.5 Hz. (equation presented) Fig. 1