Expression of WT-1, Bcl-2, and CD34 by primary renal spindle cell tumors in children

Pediatric and Developmental Pathology

Volumn 7, Issue 6, 2004, Pages 577-582

  Shao, Lei ^a   Ashley Hill, D ^b   Perlman, Elizabeth J ^c  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

Bcl 2; CD34; Clear cell sarcoma of the kidney; Mesoblastic nephroma; Wilms tumor; WT 1

Indexed keywords

CD34 ANTIGEN; PROTEIN; PROTEIN BCL 2; PROTEIN WT 1; UNCLASSIFIED DRUG;

ARTICLE; CHILDHOOD CANCER; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY TUMOR; MALE; MESOBLASTIC NEPHROMA; NEPHROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINDLE CELL CARCINOMA; SYNOVIAL SARCOMA;

ANTIGENS, CD34; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; NEPHROMA, MESOBLASTIC; PROTO-ONCOGENE PROTEINS C-BCL-2; SARCOMA; SARCOMA, CLEAR CELL; SARCOMA, SYNOVIAL; TUMOR MARKERS, BIOLOGICAL; WILMS TUMOR; WT1 PROTEINS;

EID: 12544256637     PISSN: 10935266     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10024-004-4037-6     Document Type: Article

References (23)

1. Beckwith JB. Renal neoplasms of childhood. In: Sternberg SS, Ed. Diagnostic Surgical Pathology. Philadelphia: Lippincott William & Wilkins. 1999;1825-1853.
2. Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a Zinc finger polypeptide gene at human chromosome 11 Wilms tumor locus. Cell 1990;60:509-520.
3. Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC. Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome. Cancer Res 1994;54:2331-2333.
4. Huang A, Campbell CE, Bonetta L, et al. Tissue developmental and tumor-specific expression of divergent transcripts in Wilms tumor. Science 1990;250:991-994.
5. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ. Transcriptional repression mediated by Wilms tumor gene product. Science 1991;253:1550-1553.
6. Haber DA, Park S, Maheswaran S, et al. WT-1 mediated growth suppression of Wilms tumor cells expressing a WT-1 splicing variant. Science 1993;262:2057-2059.
7. Mundlos S, Pelletier J, Darveau A, Bachmann M, Winterpacht A, Zabel B. Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissue. Development 1993;119:1329-1341.
8. Ghanem MA, Van der Kwast TH, Hollander JD, et al. Expression and prognostic value of Wilms tumor 1 and early growth response 1 protein in nephroblastoma. Clin Cancer Res 2000;6:4265-4271.
9. Ramani P, Cowell JK. The expression pattern of Wilms tumor gene (WT-1) product in normal tissues and pediatric renal tumors. J Pathol 1996;179:162-168.
10. Grubb GR, Yun K, Williams BR, Eccles MR, Reeve AE. Expression of WT-1 protein in fetal kidneys and Wilms tumors. Lab Invest 1994;71:472-479.
11. Pritchard-Jones K, Fleming S, Davidsin D, et al. The candidate Wilms tumor gene is involved in genitourinary development. Nature 1990;346:194-197.
12. Charles AK, Mall S, Watson J, Berry PJ. Expression of the Wilms tumor gene WT-1 in the developing human and in pediatric renal tumors: an immunohistochemical study. Mod Pathol 1997;50:138-144.
13. Hill DA, Pfeifer JD, Marley EF. WT-1 staining reliably differentiates desmoplastic small round cell tumor from Ewing sarcoma/primitive neuroectodermal tumor, an immunohistochemical and molecular diagnostic study. Am J Clin Pathol 2000;114:345-353.
14. Barnoud R, Sabourin JC, Pasquier D, Ranchere D, Bailly C, Terrier-Lacombe MJ. Immunohistochemical expression of WT-1 by desmoplastic small round cell tumor: a comparative study with other small round tumors. Am J Surg Pathol 2000;24:830-836.
15. Roberts F, McCall AE, Burnett RA. Malignant mesothelioma: a comparison of biopsy and postmortem material by light microscopy and immunohistochemistry. J Clin Pathol 2001;54:766-770.
16. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts and protein products of Bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 1986;83:5214-5218.
17. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-346.
18. Mayo MW, Wang CY, Drouin SS. WT-1 modulate apoptosis transcriptionally upregulating the Bcl-2 protooncogene. EMBOJ 1999;18:3990-4003.
19. Re GG, Hazen-Martin DJ, El Bahtimi RE, Brownlee NA, Willingham MC, Garvin AJ. Prognostic significance of Bcl-2 in Wilms tumor and oncogenic potential of Bel-XL in rare tumor cases. Int J Cancer 1999;84:192-200.
20. Miettinen M, Sarlomo-Rikala M, Kovatich AJ. Cell-type and tumor type-related patterns of Bcl-2 reactivity in mesenchymal cells and soft tissue tumors. Virchows Arch 1998;433:255-260.
21. Suster S, Fisher C, Moran C. Expression of Bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces and gastrointestinal tract. Am J Surg Pathol 1998;22:863-872.
22. Viguer J, Jimenez-Heffernan JA, Vicandi B, Lopez-Ferrer P, Gamello G. Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: a morphologic and immunocytochemical analysis of Bcl-2 protein expression. Cancer 1998;84:50-56.
23. Miettinen M, Limon J, Niezabitowski A, Lasota J. Patterns of keratin polypeptides in 110 biphasic, monophasic and poorly differentiated synovial sarcomas. Virchows Arch 2000;437:275-83.