6,7-Dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-Like growth factor (IGF) to IGF-binding proteins: Optimization of the 1-position benzoyl side chain

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 11, 2003, Pages 1927-1930

  Zhu, Yun Fei ^a   Wilcoxen, Keith ^a   Gross, Timothy ^a   Connors, Patrick ^a   Strack, Nathalie ^a   Gross, Raymond ^a   Huang, Charles Q ^a   McCarthy, James R ^a   Xie, Qiu ^a   Ling, Nicholas ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDROXYISOQUINOLINE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; SOMATOMEDIN; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 12444344925     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00321-4     Document Type: Article

References (9)

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2. For recent reviews, see: (a) . For recent reviews, see: Roith D.L., Bondy C., Yakar S., Liu J., Butler A. Endocr. Rev. 22:2001;53 (b) Jones J.I., Clemmons D.R. Endocr. Rev. 16:1995;3.
3. (a) Shimasaki S., Ling N. Progress in Growth Factor Res. 3:1992;243
4. (b) Shimasaki S., Shimonaka M., Zhang H., Ling N. J. Biol. Chem. 266:1991;10646.
5. Leong S.R., Baxter R.C., Camerato T., Dai J., Wood W.I. Mol. Endocr. 6:1992;870.
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8. Redel J., Bouteville A. Bull. Soc. Chim. Fr. 1949;443.
9. The program Pallas from CompuDrug Ltd was used to calculate the logP value.