Identification of a Nonpeptide Ligand That Releases Bioactive Insulin-like Growth Factor-I from Its Binding Protein Complex

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 32419-32422

  Liu, Xin Jin ^a   Xie, Qui ^a   Zhu, Yun Fei ^a   Chen, Chen ^a   Ling, Nicholas ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; DISEASES; INSULIN; METABOLISM; PROTEINS;

MITOGENIC ACTIVITIES;

BIOCHEMISTRY;

1 (3,4 DIHYDROXYBENZOYL) 3 HYDROXYCARBONYL 6,7 DIHYDROXYISOQUINOLINE; ISOQUINOLINE DERIVATIVE; LIGAND; NBI 31772; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; CATECHOL DERIVATIVE; RADIOACTIVE IODINE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOASSAY; COMPLEX FORMATION; CONCENTRATION RESPONSE; DIABETES MELLITUS; DOSE RESPONSE; DRUG SCREENING; HORMONE RELEASE; INTERSTITIAL FLUID; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; ARMYWORM; BINDING COMPETITION; CELL LINE; CHEMICAL STRUCTURE; DRUG EFFECT; GENETIC TRANSFECTION; HUMAN; KINETICS; METABOLISM; RADIOASSAY;

ANIMALIA;

ANIMALS; BINDING, COMPETITIVE; CATECHOLS; CELL LINE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; IODINE RADIOISOTOPES; ISOQUINOLINES; KINETICS; LIGANDS; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECOMBINANT PROTEINS; SPODOPTERA; TRANSFECTION;

EID: 0035980066     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100299200     Document Type: Article

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