Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 4001-4010

  Chen, C ^a   Zhu, Y F ^a   Liu, X J ^a   Lu, Z X ^a   Xie, Q ^a   Ling, N ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DIHYDROXYBENZOYL) 3 HYDROXYCARBONYL 6,7 DIHYDROXYISOQUINOLINE; 1 (3,4 DIHYDROXYBENZOYL) 3,6,7 TRIHYDROXYISOQUINOLINE; INHIBITOR PROTEIN; ISOQUINOLINE DERIVATIVE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD; CELL SURFACE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MITOGENESIS; NONHUMAN; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ANIMALS; BINDING, COMPETITIVE; CELL DIVISION; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; RECEPTOR, IGF TYPE 1; RECEPTOR, IGF TYPE 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035829434     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010304b     Document Type: Article

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