The impact of immune-activating processes following transplantation on chronic allograft nephropathy

Kidney International

Volumn 64, Issue 3, 2003, Pages 1125-1133

  Heidenhain, Christoph ^b   Reutzel Selke, Anja ^b   Bachmann, Ulrike ^b   Jonas, Sven ^b   Pascher, Andreas ^b   Ulrich, Frank ^b   Pratschke, Johann ^b   Neuhaus, Peter ^b   Volk, Hans Dieter ^b   Tullius, Stefan G ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NONE

Author keywords

Allorecognition; Chronic graft deterioration; Immune activation; Rat model; Renal transplantation

Indexed keywords

ALLOANTIGEN; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DETERIORATION; DOSE TIME EFFECT RELATION; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; LONG TERM EXPOSURE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; RAT; RISK FACTOR; RNA ANALYSIS; SIMULATION; SKIN GRAFT; STATISTICAL SIGNIFICANCE; SURVIVAL; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 12444329964     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00190.x     Document Type: Article

References (23)

1. HARIHARAN S, JOHNSON CP, BRESNAHAN BA, et al: Improved graft survival after renal transplantation in the United States, 1988-1996. N Engl J Med 342:605-612, 2000
2. SCHWEITZER EJ, MATAS AJ, GILLINGHAM KJ, et al: Causes of renal allograft loss. Progress in the 1980s, challenges for the 1990s. Ann Surg 214:679-883, 1991
3. TULLIUS SG, TILNEY NL: Both, alloantigen-dependent and independent factors influence chronic allograft rejection. Transplantation 59:313-318, 1995
4. CHERTOW GM, MILFORD EL, MACKENZIE HS, BRENNER BM: Antigen independent determinants of cadaveric kidney allograft failure. JAMA 76:1732-1736, 1996
5. NAGANO H, TILNEY NL: Chronic allograft failure: The clinical problem. Am J Med Sci 313:305-309, 1997
6. RUSH D, NICKERSON P, GOUGH J, et al: Beneficial effects of treatment of early subclinical rejection: A randomized study. J Am Soc Nephrol 9:2129-2134, 1998
7. KIRK AD, JACOBSON LM, HEISEY DM, et al: Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function. Transplantation 68:1578-1582, 1999
8. ISHANI A, ERTURK S, HERTZ MI, et al: Predictors of renal function following lung or heart-lung transplantation. Kidney Int 61:2228-2234, 2002
9. GOLDSTEIN DJ, ZUECH N, SEHGAL V, et al: Cyclosporine-associated end-stage nephropathy after cardiac transplantation. Transplantation 63:664-668, 1997
10. MYERS BD, NEWTON L: Cyclosporine-induced chronic nephropathy: An obliterative microvascular renal injury. J Am Soc Nephrol 2:S45-S52, 1991
11. COOPERSMITH CM, BRENNAN DC, MILLER B, et al: Renal transplantation following previous heart, liver, and lung transplantation: An 8-year single-center experience. Surgery 130:457-462, 2001
12. KERN F, ODE-HAKIM S, NUGEL H, et al: Peripheral T cell activation in long-term renal transplant patients: concordant upregulation of adhesion molecules and cytokine gene transcription. J Am Soc Nephrol 7:2476-2482, 1996
13. LEMSTROM K, KOSKINEN P, KROGERUS L, et al: Cytomegalovirus antigen expression, endothelial cell proliferation, and intimal thickening in rat cardiac allografts after cytomegalovirus infection. Circulation 92:2594-2604, 1995
14. LEE S: An improved technique of renal transplantation in the rat. Surgery 61:771-773, 1967
15. DIAMOND JR, TILNEY NL, FRYE J, et al: Progressive albuminuria and glomerulosclerosis in a rat model of chronic allograft rejection. Transplantation 54:710-716, 1992
16. CECKA JM: The UNOS scientific renal transplant registry. Clin Transpl 1-21, 1999
17. KOSKINEN P, LEMSTRÖM K, HÄYRY P: Chronic rejection. Curr Opin Nephrol Hypertens 5:269-272, 1996
18. HALLORAN PF, MELK A, BARTH C: Rethinking chronic allograft nephropathy: The concept of accelerated senescence. J Am Soc Nephrol 10:167-181, 1999
19. HANCOCK WW, WHITLEY DW, TULLIUS SG, et al: Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 56:643-650, 1993
20. TULLIUS SG, HANCOCK WW, HEEMANN UW, et al: Reversibility of chronic renal allograft rejection. Critical effect of time after transplantation suggests both host immune dependent and independent phases of progressive injury. Transplantation 58:93-99, 1994
21. WONG WK, ROBERTSON H, CARROLL HP, et al: Tubulitis in renal allograft rejection: Role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intra-epithelial T cells. Transplantation 75:505-514, 2003
22. HAMMER MH, SCHRODER G, RISCH K, et al: Antigen-dependent transgene expression in kidney transplantation: A novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol 13:511-518, 2002
23. REINKE P, PROSCH S, KERN F, VOLK HD: Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant patients. Transpl Infect Dis 1:157-164, 1999