Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3657-3660

  Chen, Xiaoqi ^a,b   Kempf, Dale J ^a   Li, Lin ^a   Sham, Hing L ^a   Vasavanonda, Sudthida ^a   Wideburg, Norman E ^a   Saldivar, Ayda ^a   Marsh, Kennan C ^a   McDonald, Edith ^a   Norbeck, Daniel W ^a  

^a ABBOTT LABORATORIES   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; PROTEINASE INHIBITOR; RITONAVIR;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PLASMA; RAT; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

EID: 12444327171     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.043     Document Type: Article

References (10)

1. Kempf D., Sham H. Curr. Pharm. Des. 2:1996;225, and references therein.
2. Kempf D.J., Sham H.L., Marsh K.C., Flentge C.A., Betebenner D., Green B.E., McDonald E., Vasavanonda S., Saldivar A., Wideburg N.E., Kati W.M., Ruiz L., Zhao C., Fino L.M., Patterson J., Molla A., Plattner J.J., Norbeck D.W. J. Med. Chem. 41:1998;602.
3. Molla A., Vasavanonda S., Kumar G., Sham H.L., Johnson M., Grabowski B., Denissen J.F., Kohlbrenner W., Plattner J.J., Leonard J.M., Norbeck D.W., Kempf D.J. Virology. 250:1998;255.
4. Molla A., Korneyeva M., Gao Q., Vasavanonda S., Schipper P.J., Mo H.-M., Markowitz M., Chernyavskiy T., Niu P., Lyons N., Hsu A., Granneman G.R., Boucher C.A.B., Leonard J.M., Norbeck D.W., Kempf D.J. Nat. Med. 2:1996;760.
5. Ghosh A.K., Thompson W.J., Fitzgerald P.M.D., Culberson J.C., axel M.G., McKee S.P., Huff J.R., Anderson P.S. J. Med. Chem. 37:1994;2506.
6. Kempf D.J., Marsh K.C., Kumar G., Rodrigues A.D., Denissen J.F., McDonald E., Kukulka M.J., Hsu A., Granneman G.R., Baroldi P.A., Sun E., Pizzuti D., Plattner J.J., Norbeck D.W., Leonard J.M. Antimicrob. Agents Chemother. 41:1997;654.
7. Tong L., Pav S., Mui S., Lamarre D., Yoakim C., Beaulier P., Anderson P.C. Structure. 3:1995;33.
8. Kempf D.J., Marsh K.C., Fino L.C., Bryant P., Craig-Kennard A., Sham H.L., Zhao C., Vasavanonda S., Kohlbrenner W.E., Wideburg N.E., Saldivar A., Green B.E., Green B.E., Norbeck D.W. Bioorg. Med. Chem. 2:1994;847.
9. Kempf D.J., Codacovi L., Wang X.C., Kohlbrenner W.E., Wideburg N.E., Vasavanonda S., Marsh K.C., Bryant P., Sham H.L., Green B.E., Betebenner D.A., Erickson J., Norbeck D.W. J. Med. Chem. 36:1993;320.
10. Chen X., Li L., Kempf D.J., Sham H.J., Wideburg N.E., Saldivar A., Vasavanonda S., Marsh K.C., McDonald E., Norbeck D.W. Bioorg. Med. Chem. Lett. 6:1996;2847.