Barriers to Australian physicians' and paediatricians' involvement in randomised controlled trials

Medical Journal of Australia

Volumn 182, Issue 2, 2005, Pages 59-65

  Caldwell, Patrina H Y ^a   Craig, Jonathan C ^a,b   Butow, Phyllis N ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUSTRALIA; CLINICAL RESEARCH; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GROUP PSYCHOLOGY; HEALTH SURVEY; HUMAN; MALE; MEDICAL DECISION MAKING; PEDIATRICIAN; PHYSICIAN ATTITUDE; PREDICTION; PUBLICATION; RANDOMIZATION; REWARD; SCORING SYSTEM; STATISTICAL ANALYSIS; TREATMENT PLANNING; UNCERTAINTY; VALIDATION PROCESS;

EID: 12444311770     PISSN: 0025729X     EISSN: None     Source Type: Journal    
DOI: 10.5694/j.1326-5377.2005.tb06576.x     Document Type: Article

References (27)

1. National Health and Medical Research Council. How to review the evidence: systematic identification review of the scientific literature. Handbook series on preparing clinical practice guidelines. Canberra: NHMRC, 1999.
2. Barton S. Which clinical studies provide the best evidence? The best RCT still trumps the best observational study. BMJ 2000; 321: 255-256.
3. Caldwell PHY, Murphy SB, Butow PB, et al. Clinical trials in children. Lancet 2004; 364: 803-811.
4. Lovato LC, Hill K, Hertert S, et al. Recruitment for controlled clinical trials: literature summary and annotated bibliography. Control Clin Trials 1997; 18: 328-352.
5. Siminoff LA, Zhang A, Colabianchi N, et al. Factors that predict the referral of breast cancer patients onto clinical trials by their surgeons and medical oncologists. J Clin Oncol 2000; 18: 1203-1211.
6. Prescott RJ, Counsell CE, Gillespie WJ, et al. Factors that limit the quality, number and progress of randomised controlled trials. Health Technol Assess (Washington DC) 1999; 3(20): 1-143.
7. Hunninghake DB, Darby CA, Probstfield JL. Recruitment experience in clinical trials: literature summary and annotated bibliography. Control Clin Trials 1987; 8(4 suppl): 6S-30S.
8. Taylor KM. Integrating conflicting professional roles: physician participation in randomized clinical trials. Soc Sci Med 1992; 35: 217-224.
9. Viability of cancer clinical research: patient accrual, coverage, and reimbursement. American Medical Association Council on Scientific Affairs. J Natl Cancer Inst 1991; 83: 254-259.
10. Taylor KM, Shapiro M, Soskolne CL, Margolese RG. Physician response to informed consent regulations for randomized clinical trials. Cancer 1987; 60: 1415-1422.
11. Taylor KM, Margolese RG, Soskolne CL. Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. N Engl J Med 1984; 310: 1363-1367.
12. Talyor KM, Feldstein ML, Skeel RT, et al. Fundamental dilemmas of the randomized clinical trial process: results of a survey of the 1737 Eastern Cooperative Oncology Group investigators. J Clin Oncol 1994; 12: 1796-1805.
13. Benson AB, Pregler JP, Bean JA, et al. Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study. J Clin Oncol 1991; 9: 2067-2075.
14. Swanson GM, Ward AJ. Recruiting minorities into clinical trials: toward a participant-friendly system. J Natl Cancer Inst 1995; 87: 1747-1759.
15. Fallowfield L, Ratcliffe D, Souhami R. Clinicians' attitudes to clinical trials of cancer therapy. Eur J Cancer 1997; 33: 2221-2229.
16. Taylor KM, Kelner M. Interpreting physician participation in randomized clinical trials: the Physician Orientation Profile. J Health Soc Behav 1987; 28: 389-400.
17. Ellis PM. Barriers to clinical trials for breast cancer: an investigation of doctors' attitudes towards randomised clinical trials [PhD Treatise]. The University of Sydney, 1997.
18. Microsoft Excel [computer program]. Version 2000. US: Microsoft Corporation, 2000.
19. SPSS statistical package [computer program]. Version 11.0 for Windows. Chicago, SPSS Inc, 2001.
20. Dent O. Clinical workforce surveys 2001: clinical workforce in internal medicine and paediatrics in Australia 2001. Sydney: Royal Australasian College of Physicians, 2001.
21. Caldwell PHY, Butow PN, Craig JC. Paediatricians' attitudes to randomized controlled trials involving children. J Pediatr 2002; 141: 798-803.
22. Collet JP, Floret D, Cochat P, et al. Group meetings for recruitment of children in a clinical trial. Therapie 1991; 46: 139-142.
23. Bleyer WA. Re: recruiting minorities into clinical trials: toward a participant-friendly system [letter]. J Natl Cancer Inst 1996 Mar 20; 88: 377.
24. Campbell H, Surry SAM, Royle EM. A review of randomised controlled trials published in Archives of Disease in Childhood from 1982-96. Arch Dis Child 1998; 79: 192-197.
25. Committee on Drugs, American Academy of Pediatrics. Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Pediatrics 1995; 95: 286-294.
26. Association of American Medical Colleges. Breaking the scientific bottleneck. Clinical research: a national call to action. Available at: www.aamc.org/research/calitoaction.htm (accessed Dec 2004).
27. National Health and Medical Research Council. Health and Medical Research Strategic Review - implementation of the government's response. Canberra: AusInfo, 2001: 19-20.