Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease

Cellular Physiology and Biochemistry

Volumn 15, Issue 1-4, 2005, Pages 109-116

  Markmann, André ^a   Schäfer, Stefan ^a   Linz, Wolfgang ^a   Löhn, Matthias ^a   Busch, Andreas E ^a   Wohlfart, Paulus ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Calpain 9; Dahl rats; Experimental hypertension; Gene expression; Hypertrophy, hypertensive target organ damage

Indexed keywords

CALPAIN; CALPAIN 6; CALPAIN 9; CALPASTATIN; CYSTEINE PROTEINASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; ENZYME SPECIFICITY; HEART LEFT VENTRICLE MASS; KIDNEY DISEASE; MALE; MICROALBUMINURIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; PROTEIN VARIANT; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; SALT INTAKE; SPECIES COMPARISON; SYSTOLIC HYPERTENSION; TARGET CELL DESTRUCTION; UPREGULATION;

EID: 12444251036     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083643     Document Type: Article

References (26)

1. Chen M, Won DJ, Krajewski S, Gottlieb RA: Calpain and mitochondria in ischemia/reperfusion injury. J Biol Chem 2002;277:29181-29186.
2. Perrin C, Ecarnot-Laubriet A, Vergely C, Rochette L: Calpain and caspase-3 inhibitors reduce infarct size and postischemic apoptosis in rat heart without modifying contractile recovery. Cell Mol Biol (Noisy-le-grand) 2003;49 Online Pub:OL497-505.
3. Liu X, Rainey JJ, Harriman JF, Schnellmann RG: Calpains mediate acute renal cell death: role of autolysis and translocation. Am J Physiol Renal Physiol 2001;281:F728-38.
4. Maekawa A, Lee JK, Nagaya T, Kamiya K, Yasui K, Horiba M, Miwa K, Uzzaman M, Maki M, Ueda Y, Kodama I: Overexpression of calpastatin by gene transfer prevents troponin I degradation and ameliorates contractile dysfunction in rat hearts subjected to ischemia/reperfusion. J Mol Cell Cardiol 2003;35:1277-1284.
5. Singh RB, Chohan PK, Dhalla NS, Netticadan T: The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart. J Mol Cell Cardiol 2004;37:101-110.
6. Cicilini MA, Resende MM, Bissoli NS, Vasquez EC, Cabral AM: Calpain activity of hypertrophic hearts from hypertensive rats. Braz J Med Biol Res 1995;28:621-625.
7. Stella P, Soldati L, Ciurlino D, Vezzoli G, Cusi D, Bianchi G: Erythrocyte calpain activity and left ventricular mass in essential hypertension. J Hypertens 1997;15:1775-1778.
8. Dear TN, Boehm T: Identification and characterization of two novel calpain large subunit genes. Gene 2001;274:245-252.
9. Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H: Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther 1995;275:681-692.
10. 0 Brundel BJ, Ausma J, van Gelder IC, Van der Want JJ, van Gilst WH, Crijns HJ, Henning RH: Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation. Cardiovasc Res 2002;54:380-389.
11. Liebetrau M, Gabriejcic-Geiger D, Meyer P, Roether J, Hamann GF: Increased calpain expression following experimental cerebral venous thrombosis in rats. Thromb Res 2003;112:239-243.
12. Sandmann S, Yu M, Unger T: Transcriptional and translational regulation of calpain in the rat heart after myocardial infarction-effects of AT(1) and AT(2) receptor antagonists and ACE inhibitor. Br J Pharmacol 2001;132:767-777.
13. Dear N, Matena K, Vingron M, Boehm T: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics 1997;45:175-184.
14. Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K: Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem 1998;379:175-183.
15. 5 Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I: Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res 2000;91:459-463.
16. Liu K, Li L, Cohen SN: Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis. J Biol Chem 2000;275:31093-31098.
17. Lee HJ, Tomioka S, Kinbara K, Masumoto H, Jeong SY, Sorimachi H, Ishiura S, Suzuki K: Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch Biochem Biophys 1999;362:22-31.
18. Passier R, Zeng H, Frey N, Naya FJ, Nicol RL, McKinsey TA, Overbeek P, Richardson JA, Grant SR, Olson EN: CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J Clin Invest 2000;105:1395-1406.
19. Bar H, Kreuzer J, Cojoc A, Jahn L: Upregulation of embryonic transcription factors in right ventricular hypertrophy. Basic Res Cardiol 2003;98:285-294.
20. 0 Hirai S, Kawasaki H, Yaniv M, Suzuki K: Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Lett 1991;287:57-61.
21. Condorelli G, Morisco C, Latronico MV, Claudio PP, Dent P, Tsichlis P, Frati G, Drusco A, Croce CM, Napoli C: TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. Faseb J 2002;16:1732-1737.
22. Taimor G, Schluter KD, Best P, Helmig S, Piper HM: Transcription activator protein 1 mediates alpha- but not betaadrenergic hypertrophic growth responses in adult cardiomyocytes. Am J Physiol Heart Circ Physiol 2004;286:H2369-H2375.
23. Braun C, Engel M, Theisinger B, Welter C, Seifert M: CAPN 8: isolation of a new mouse calpain-isoenzyme. Biochem Biophys Res Commun 1999;260:671-675.
24. 4 Sorimachi H, Ishiura S, Suzuki K: A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. J Biol Chem 1993;268:19476-19482.
25. Dear TN, Moller A, Boehm T: CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6. Genomics 1999;59:243-247.
26. Averna M, De Tullio R, Salamino F, Minafra R, Pontremoli S, Melloni E: Agedependent degradation of calpastatin in kidney of hypertensive rats. J Biol Chem 2001;276:38426-38432.