Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits

Journal of Nutritional Biochemistry

Volumn 15, Issue 2, 2004, Pages 96-102

  Sauls, Derrick L ^a   Boyd, Leon C ^b   Allen, Jonathan C ^b   Hoffman, Maureane ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Folate metabolism; Homocysteine; Hyperhomocysteinemia; Lipid peroxidation

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; MALONALDEHYDE;

ADAPTATION; ADULTHOOD; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXCRETION; FOLIC ACID DEFICIENCY; JUVENILE; KINETICS; LIVER LEVEL; LONG TERM EXPOSURE; NONHUMAN; OXIDATIVE STRESS; PLASMA CLEARANCE; QUANTITATIVE ANALYSIS; RABBIT; REGULATORY MECHANISM;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 1242351281     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2003.09.010     Document Type: Article

References (30)

1. Finkelstein J.D. The metabolism of homocysteine pathways and regulation . Eur J Pediatr. 157:(Suppl 2):1998;S40-44.
2. McCully K.S. Vascular pathology of homocysteinemia implications for the pathogenesis of arteriosclerosis . Am J Pathol. 56:(1):1969;111-128.
3. McCully K.S., Wilson R.B. Homocysteine theory of arteriosclerosis. Atherosclerosis. 22:(2):1975;215-227.
4. McCully K.S. Homocysteine, folate, vitamin B6, and cardiovascular disease [editorial; comment] [see comments]. JAMA. 279:(5):1998;392-393.
5. Kang S.S., Wong P.W., Malinow M.R. Hyperhomocyst (e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 12:1992;279-298.
6. Malinow M.R., Kang S.S., Taylor L.M., Wong P.W., Coull B., Inahara T., Mukerjee D., Sexton G., Upson B. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. Circulation. 79:(6):1989;1180-1188.
7. Reis R.P., Azinheira J., Reis H.P., Bordalo A., Santos L., Adao M., Pina J.E., Ferreira N.C., Luis A.S. Homocysteinaemia after methionine overload as a coronary artery disease risk factor importance of age and homocysteine levels . Coron Artery Dis. 6:(11):1995;851-856.
8. Andersson A., Brattstrom L., Israelsson B., Isaksson A., Hamfelt A., Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest. 22:(2):1992;79-87.
9. Graham I.M., Daly L.E., Refsum H.M., Robinson K., Brattstrom L.E., Ueland P.M., Palma-Reis R.J., Boers G.H., Sheahan R.G., Israelsson B., Uiterwaal C.S., Meleady R., McMaster D., Verhoef P., Witteman J., Rubba P., Bellet H., Wautrecht J.C., de Valk H.W., Sales Luis A.C., Parrot-Rouland F.M., Tan K.S., Higgins I., Garcon D., Andria G., et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 277:(22):1997;1775-1781.
10. Finkelstein J.D., Martin J.J. Homocysteine. Int J Biochem Cell Biol. 32:(4):2000;385-389.
11. Bostom A.G., Shemin D., Lapane K.L., Nadeau M.R., Sutherland P., Chan J., Rozen R., Yoburn D., Jacques P.F., Selhub J., Rosenberg I.H. Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients. Atherosclerosis. 123:(1-2):1996;193-202.
12. Stepanuk M. Homocysteine, Cysteine and Taurine in Modern Nutrition in Health and Disease. In: Shils M et al. , Editors. 1999, Williams & Wilkins: Baltimore, MD. p. 545.
13. Sassi S., Cosmi B., Palareti G., Legnani C., Grossi G., Musolesi S., Coccheri S. Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels. Hematologica. 87:(9):2002;957-964.
14. Norlund L., Grubb A., Fex G., Leksell H., Nilsson J.E., Schenck H., Hultberg B. The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C. Clin Chem Lab Med. 36:(3):1998;175-178.
15. Rasmussen K., Moller J., Lyngbak M., Pedersen A.M., Dybkjaer L. Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem. 42:(4):1996;630-636.
16. McCully K.S. Growth disorders and homocysteine metabolism. Ann Clin Lab Sci. 5:(3):1975;147-152.
17. Sauls D., Wolberg A., Hoffman M. Hyperhomocysteinemia induces alterations in fibrinogen function and fibrin clot structure in a rabbit model. J Thromb Hemostasis. 1:(2):2003;300-306.
18. McCully K.S., Ragsdale B.D. Production of arteriosclerosis by homocysteinemia. Am J Pathol. 61:(1):1970;1-11.
19. Guttormsen A.B., Mansoor A.M., Fiskerstrand T., Ueland P.M., Refsum H. Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin Chem. 39:(7):1993;1390-1397.
20. King M.F., Boyd L.C., Sheldon B.F. Effects of phospholipids on lipid oxidation of a salmon oil model system. J Am Oil Chem Soc. 69:1992;237-242.
21. Boyd L.C., King M.F., Sheldon B.F. A rapid method for determining the oxidation of n-3 fatty acids. J Am Oil Chemists Soc. 69:1992;325-330.
22. Boyd L.C., Drye N.C., Hansen A.P. Isolation and characterization of whey phospholipids. J Dairy Sci. 82:(12):1999;2550-2557.
23. Welch G.N., Upchurch G.R., Loscalzo J. Homocysteine, oxidative stress, and vascular disease. Hosp Pract (Off Ed). 32:(6):1997;81-82. 85, 88-92.
24. Fuchs D., Jaeger M., Widner B., Wirleitner B., Artner-Dworzak E., Leblhuber F. Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake? Clin Chem Lab Med. 39:(8):2001;691-694.
25. Huang R.F., Hsu Y.C., Lin H.L., Yang F.L. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr. 131:(1):2001;33-38.
26. Hernanz A., Fernandez-Vivancos E., Montiel C., Vazquez J.J., Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci. 67:(11):2000;1317-1324.
27. Mosharov E., Cranford M.R., Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry. 39:(42):2000;13005-13011.
28. Vitvitsky V., Mosharov E., Tritt M., Ataullakhanov F., Banerjee R. Redox regulation of homocysteine-dependent glutathione synthesis. Redox Rep. 8:(1):2003;57-63.
29. Hoffman M., Stevens J.B., Autor A.P. Adaptation to hyperoxia in the neonatal rat kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase . Toxicology. 16:(3):1980;215-225.
30. Stevens J.B., Autor A.P. Proposed mechanism for neonatal rat tolerance to normobaric hyperoxia. Fed Proc. 39:(13):1980;3138-3143.