The human RAP250 gene: Genomic structure and promoter analysis

Gene

Volumn 327, Issue 2, 2004, Pages 233-238

  Antonson, Per ^a   Al Beidh, Farah ^a   Matthews, Jason ^a   Gustafsson, Jan Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Agouti; Chromosome 2; Chromosome 20; Coactivator; Nuclear receptor

Indexed keywords

AGOUTI RELATED PROTEIN; ALANINE; CELL NUCLEUS RECEPTOR; GUANINE; LUCIFERASE; THIAMINE; THYMIDINE KINASE; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING SITE; CHROMOSOME 2; DNA FLANKING REGION; DNA SPLICING; DONOR SITE; EXON; GENE ACTIVITY; GENE STRUCTURE; GENETIC ORGANIZATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN GENE RAP250; HUMAN GENOME; LINKAGE ANALYSIS; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

AGOUTI;

EID: 1242331809     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2003.11.022     Document Type: Article

References (26)

1. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402.
2. Antonson P., Schuster G.U., Wang L., Rozell B., Holter E., Flodby P., Treuter E., Holmgren L., Gustafsson J.-Å. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol. Cell. Biol. 23:2003;1260-1268.
3. Blake M.C., Jambou R.C., Swick A.G., Kahn J.W., Azizkhan J.C. Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol. Cell. Biol. 10:1990;6632-6641.
4. Bultman S.J., Michaud E.J., Woychik R.P. Molecular characterization of the mouse agouti locus. Cell. 71:1992;1195-1204.
5. Caira F., Antonson P., Pelto-Huikko M., Treuter E., Gustafsson J.-Å. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275:2000;5308-5317.
6. Chu C.S., Trapnell B.C., Curristin S., Cutting G.R., Crystal R.G. Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA. Nat. Genet. 3:1993;151-156.
7. Feltkamp D., Wiebel F.F., Alberti S., Gustafsson J.-Å. Identification of a novel DNA binding site for nuclear orphan receptor OR1. J. Biol. Chem. 274:1999;10421-10429.
8. Glass C.K., Rosenfeld M.G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14:2000;121-141.
9. Hapgood J.P., Riedemann J., Scherer S.D. Regulation of gene expression by GC-rich DNA cis-elements. Cell Biol. Int. 25:2001;17-31.
10. Heery D.M., Kalkhoven E., Hoare S., Parker M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 387:1997;733-736.
11. Hermanson O., Glass C.K., Rosenfeld M.G. Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol. Metab. 13:2002;55-60.
12. Ko L., Cardona G.R., Chin W.W. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6212-6217.
13. Kuang S.Q., Liao L., Zhang H., Pereira F.A., Yuan Y., DeMayo F.J., Ko L., Xu J. Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J. Biol. Chem. 277:2002;45356-45360.
14. Kwon H.Y., Bultman S.J., Loffler C., Chen W.J., Furdon P.J., Powell J.G., Usala A.L., Wilkison W., Hansmann I., Woychik R.P. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc. Natl. Acad. Sci. U. S. A. 91:1994;9760-9764.
15. Lee S.K., Anzick S.L., Choi J.E., Bubendorf L., Guan X.Y., Jung Y.K., Kallioniemi O.P., Kononen J., Trent J.M., Azorsa D., Jhun B.H., Cheong J.H., Lee Y.C., Meltzer P.S., Lee J.W. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J. Biol. Chem. 274:1999;34283-34293.
16. Lu J., Lee W., Jiang C., Keller E.B. Start site selection by Sp1 in the TATA-less human Ha-ras promoter. J. Biol. Chem. 269:1994;5391-5402.
17. Mahajan M.A., Samuels H.H. A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol. Cell. Biol. 20:2000;5048-5063.
18. Misra P., Qi C., Yu S., Shah S.H., Cao W.Q., Rao M.S., Thimmapaya B., Zhu Y., Reddy J.K. Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. J. Biol. Chem. 277:2002;20011-20019.
19. Ohbayashi T., Schmidt E.E., Makino Y., Kishimoto T., Nabeshima Y., Muramatsu M., Tamura T. Promoter structure of the mouse TATA-binding protein (TBP) gene. Biochem. Biophys. Res. Commun. 225:1996;275-280.
20. Pena A., Reddy C.D., Wu S., Hickok N.J., Reddy E.P., Yumet G., Soprano D.R., Soprano K.J. Regulation of human ornithine decarboxylase expression by the c-Myc. Max protein complex. J. Biol. Chem. 268:1993;27277-27285.
21. Sawadogo M., Roeder R.G. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell. 43:1985;165-175.
22. Torchia J., Rose D.W., Inostroza J., Kamei Y., Westin S., Glass C.K., Rosenfeld M.G. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 387:1997;677-684.
23. Voisey J., van Daal A. Agouti: from mouse to man, from skin to fat. Pigment Cell Res. 15:2002;10-18.
24. Zhu Y., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K. Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 275:2000;13510-13516.
25. Zhu Y., Qi C., Cao W.Q., Yeldandi A.V., Rao M.S., Reddy J.K. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc. Natl. Acad. Sci. U. S. A. 98:2001;10380-10385.
26. Zhu Y.-J., Crawford S.E., Stellmach V., Dwivedi R.S., Rao M.S., Gonzalez F.J., Qi C., Reddy J.K. Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. J. Biol. Chem. 278:2003;1986-1990.