From interception to incorporation: Degeneracy and promiscuous recognition as precursors of a paradigm shift in immunology

Molecular Immunology

Volumn 40, Issue 14-15, 2004, Pages 985-991

  Parnes, Ohad ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cross reactivity; Degeneracy; Immunological recognition; Specificity

Indexed keywords

ANTIBODY;

ANTIGEN PRESENTING CELL; AUTOIMMUNITY; CELL CLONING; CROSS REACTION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGY; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THEORY; TUMOR IMMUNOLOGY;

EID: 1242315571     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2003.11.021     Document Type: Article

References (68)

1. Behring, E.B., 1894. Infection und Desinfection. Versuch einer systematischer Darstellung der Lehre von den Infectionsstoffen und Desinfectionsmitteln. In Bekämpfung der Infektionskrankheiten. Georg Thieme, Leipzig.
2. Berzofsky J.A., Schechter A.N. The concepts of crossreactivity and specificity in immunology. Mol. Immunol. 18:1981;751-763.
3. Bhardwaj V., Kumar V., Geysen H.M., Sercarz E.E. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity. J. Immunol. 151:1993;5000-5010.
4. Billingham R.E., Medawar P.B. Pigment spread in mammalian skin: serial propagation and immunity reactions. Heredity. 4:1950;141-164.
5. Bogen B. Peripheral t cell tolerance as a tumor escape mechanism - deletion of cd4(+) t cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur. J. Immunol. 26:1996;2671-2679.
6. Brent, L., Medawar, P.B., 1958. Tolerance and auto-immune phenomena. In: Tunneval, G. (Ed.), Recent Progress in Microbiology. Symposium III: Tissue specific antibodies, Blackwell Scientific Publications, London, Stockholm, pp. 181-190.
7. Burnet, F.M., 1959. The Clonal Selection theory of Acquired Immunity. Cambridge University Press, Cambridge.
8. Burnet F.M. The concept of immunological surveillance. Prog. Exp. Tumor Res. 13:1970;1-27.
9. Burnet F.M. Immunological surveillance in neoplasia. Transplant. Rev. 7:1971;3-25.
10. Cohen I.R. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:1992;490-494.
11. Cohen I.R. Discrimination and dialogue in the immune system. Semin. Immunol. 12:2000a;215-219.
12. Cohen, I.R., 2000b. Tending Adma's Garden. Evolving the Cognitive immune Self. Academic Press, San Diego.
13. Cohen I.R. Antigenic mimicry, clonal selection and autoimmunity. J. Autoimmun. 16:2001a;337-340.
14. Cohen, I.R., 2001b. The creation of immune specificity. In: Segel, L.A., Cohen, I.R. (Eds.), Design Principles for Immune System & Other Autonomous Systems. Oxford University Press, New York, pp. 151-159.
15. Cohen I.R. Peptide therapy for type I diabetes: the immunological homunculus and the rationale for vaccination. Diabetologia. 45:2002;1468-1474.
16. Coutinho A. Will the idiotypic network help to solve natural tolerance? Trends Immunol. 24:2003;53-54.
17. Damian R.T. Molecular mimicry: antigen sharing by parasite and host and its consequences. Am. Naturalist. 98:1964;129-149.
18. Dunn G.P., Bruce A.T., Ikeda H., Old L.J., Schreiber R.D. Cancer immunoediting: from immunosurveillance to tumor escape. Nature Immunol. 3:2002;991-998.
19. Durkin H.G., Waksman B. Thymus and tolerance. Is regulation the major function of the thymus? Immunol. Rev. 182:2001;33-57.
20. Edelman, G.M., 1974. Origins and mechanisms of specificity in clonal selection. In: Edelman, G.M. (Ed.), Cellular Selection and Regulation in the Immune Response. Raven Press, New York, pp. 1-38.
21. Edelman G.M., Gally J.A. Degeneracy and complexity in biological systems. Proc. Natl. Acad. Sci. 98:2001;13763-13768.
22. Eisen H.N. Specificity and degenracy in antigen recognition: Yin and Yang in the immune system. Annu. Rev. immunol. 19:2001;1-21.
23. Eisen H.N., Little J.R., Steiner L.A., Simms E.S., Gray W. Degeneracy in the secondary immune response: stimulation of antibody formation by cross-reacting antigens. Israel. J. Med. Sci. 5:1969;338-351.
24. Friston K.J., Price C.J. Degeneracy and redundancy in cognitive anatomy. Trends Cogn. Sci. 7:2003;151-152.
25. Froude, J., Gibofsky, A., Buskirk, D.R., Khanna, A., Zabriskie, J.B., 1989. Cross-reactivity between streptococus and human tissue: a model of molecular mimicry and autoimmunity. In: Oldstone, M.B.A. (Ed.), Molecular Mimicry: Cross-reactivity Between Microbes and Host Proteins as a Cause of Autoimmunity, Springer, Berlin, pp. 5-26.
26. Grachev M.A., Budowsky E.I., Mirzabekov A.D., Krutilina A.I., Sandakhchiev L.S. A test for the "degeneracy" of valine-acceptor ribonucleic acid. Biochim. Biophys. Acta. 108:1965;506-509.
27. Janeway, C.A., Jr., 1992. The immune system evolved to discriminate infectious nonself from noninfectious self., 11-6 Jan. 1992.
28. Jerne, N.K., 1974. Clonal selection in a lymphocyte network. In: Edelman, G.M. (Ed.), Cellular Selection and Regulation in the Immune Response. Raven Press, New York, pp. 39-48.
29. Jerne N.K. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur). 125C:1974a;373-389.
30. Jones O.W., Nirenberg M.W. Degeneracy in the amino acid code. Biochim. Biophys. Acta. 119:1966;400-406.
31. Kämmerer, H., 1915. Die Abwehrkräfte des Körpers. Teubner, Leipzig.
32. Kay, L.E., 2000. Who wrote the book of life? A history of the genetic code. Stanford University Press, Stanford CA.
33. Khong H.T., Restifo N.P. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nature Immunol. 3:2002;999-1005.
34. Kohm A.P., Fuller K.G., Miller S.D. Mimicking the way to autoimmunity: an evolving theory of sequence and structural homology. Trends Microbiol. 11:2003;101-105.
35. Kyewski B., Derbinsk I.J., Gotter J., Klein L. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol. 23:2002;364-371.
36. Landsteiner, K., 1947. The Specificity of Serological Reactions. Harvard University Press, Cambridge, Mass.
37. Landsteiner K., van der Scheer J. On the cross-reactions of immune sera to azoproteins. J. Exp. Med. 63:1936;325-399.
38. Leng Q., Bentwich Z. Beyond self and nonself: Fuzzy recognition of the immune system. Scand. J. Immunol. 56:2002;224-232.
39. Marchalonis J.J., Adelman M.K., Robey I.F., Schluter S.F., Edmundson A.B. Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans. J. Mol. Recognit. 14:2001;110-121.
40. Matzinger P. Tolerance, danger, and the extended family. Ann. Rev. Immunol. 12:1994;991-1045.
41. Matzinger P. The danger model in its historical context. Scand. J. Immunol. 54:2001;4-9.
42. Maverakis E., van den Elzen P., Sercarz E. Self-reactive T cells and degenracy of T cell recognition: Evolving concepts - from sequence homology to shape mimicry and TCR flexibility. J. Autoimmun. 16:2001;201-209.
43. Mazumdar, P.M.H., 1995. Species and Specificity. An Interpretation of the History of Immunology. Cambridge University Press, Cambridge.
44. Oldstone, M.B.A., 1989. Molecular Mimicry. Cross-reactivity between microbes and host proteins as a cause of autoimmunity. In: Current Topics in Microbiology and Immunology. Springer, Berlin.
45. Pardoll D. Does the immune system see tumors as foreign or self? Annu. Rev. immunol. 21:2003;807-839.
46. Parnes, O., 2003a. From agents to cells: Theodor Schwann's research notes of the years 1835-1838. In: Holmes, F.L., Renn, J., Rheinberger, H.J., (Eds.), Reworking the Bench. Research Notes in the History of Science. Kluwer, Dordrecht, pp. 119-140.
47. Parnes O. 'Trouble from within': allergy, autoimmunity, and pathology in the first half of the twentieth century. Stud. History Phil. Biol. Biomed. Sci. 34:2003b;425-454.
48. Peirce, C.S., 1976. The new elements of mathematics. Mouton, The Hague.
49. Pezzano M., Samms M., Martinez M., Guyden J. Questionable thymic nurse cells. Microbiol. Mol. Biol. Rev. 65:2001;390-403.
50. Pittet M.J., Zippelius A., Valormi D., Speiser D.E. Degeneracy instead of specificity: is this a solution to cancer immunotherapy? Trends Immunol. 23:2002;344.
51. Poletaev A., Osipenko L. General network of natural autoantibodies as immunological homunculus (Immunculus). Autoimmun. Rev. 2:2003;264-271.
52. Poletaev A.B. The immunological homunculus (immunculus) in normal state and pathology. Biochemistry (Moscow). 67:2002;600-608.
53. Schultze J.L. Degeneracy instead of specificity: is this a solution to cancer immunotherapy? Trends Immunol. 23:2002;343-344.
54. Schwartz M., Cohen I.R. Autoimmunity can benefit self-maintenance. Immunol. Today. 21:2000;265-268.
55. Silverstein, A.M., 1989. A History of Immunology. Academic Press, San Diego.
56. Silverstein, A.M., 2002. Paul Ehrlich's Receptor Immunology: The Magnificent Obsession. Academic Press, San Diego.
57. Sole R.V., Ferrer-Cancho R., Monoya J.M., Valverde S. Selection, tinkering, and emergence in complex networks. Complexity. 8:2003;20-33.
58. Sperling R., Francus T., Siskind G.W. Degeneracy of antibody specificity. J. Immunol. 131:1983;882-885.
59. Tallquist M.D., Yun T.J., Pease L.R. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184:1996;1017-1026.
60. Talmage D.W. Allergy and Immunology. Annu. Rev. Med. 8:1957;239-256.
61. Talmage D.W. Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept. Science. 129:1959;1643-1648.
62. Tononi G., Sprons O., Edelman G.M. Measures of degeneracy and redundancy in biological networks. Proc. Natl. Acad. Sci. 96:1999;3257-3262.
63. Tyler, A., 1955. Ontogeny of immunological properties. In: Willier, B.H., Weiss, P.A., Hamburger, V., (Eds.), Analysis of Development. W.B. Saunders, Philadelphia, pp. 556-573.
64. Van Regenmortel M.H.V. From absolute to exquisite specificity. Reflections on the fuzzy nature of species, specificity and antigenic sites. J. Immunol. Methods. 216:1998;37-48.
65. Van Regenmortel M.H.V. A paradigm shift is needed in proteomics: 'structure determines function' should be replaced by 'binding determines function'. J. Mol. Recognit. 15:2002a;349-351.
66. Van Regenmortel M.H.V. Reductionism and the search for structure-function relationship in antibody molecules. J. Mol. Recognit. 15:2002b;240-247.
67. Wucherpfennig K.W. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Invest. 108:2001;1097-1104.
68. Zinsser, H., 1918. Infection and resistance, second ed. Macmillan, New York.