메뉴 건너뛰기




Volumn 15, Issue 6, 2002, Pages 349-351

A paradigm shift is needed in proteomics: 'Structure determines function' should be replaced by 'binding determines function'

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; DATABASES, PROTEIN; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEINS; PROTEOMICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036873031     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmr.603     Document Type: Editorial
Times cited : (19)

References (23)
  • 1
    • 0032146301 scopus 로고    scopus 로고
    • Structure-based drug design
    • Amzel LM. 1998. Structure-based drug design. Curr. Opin. Biotech. 9: 366-369.
    • (1998) Curr. Opin. Biotech. , vol.9 , pp. 366-369
    • Amzel, L.M.1
  • 2
    • 0036228119 scopus 로고    scopus 로고
    • Direct comparison of binding equilibrium, thermodynamic and rate constants determined by surface and solution based biophysical methods
    • Day YS, Baird CL, Rich RL, Myszka DG. 2002. Direct comparison of binding equilibrium, thermodynamic and rate constants determined by surface and solution based biophysical methods. Protein Sci. 11: 1017-1025.
    • (2002) Protein Sci. , vol.11 , pp. 1017-1025
    • Day, Y.S.1    Baird, C.L.2    Rich, R.L.3    Myszka, D.G.4
  • 3
    • 0036469060 scopus 로고    scopus 로고
    • Unraveling hot spots in binding interfaces: Progress and challenges
    • DeLano WL. 2002. Unraveling hot spots in binding interfaces: progress and challenges. Curr. Opin. Struct. Biol. 12: 14-20.
    • (2002) Curr. Opin. Struct. Biol. , vol.12 , pp. 14-20
    • DeLano, W.L.1
  • 4
    • 0035096292 scopus 로고    scopus 로고
    • Recognition between flexible protein molecules: Induced and assisted folding
    • Demchenko AP. 2001. Recognition between flexible protein molecules: induced and assisted folding. J. Mol. Recognit. 14: 42-61.
    • (2001) J. Mol. Recognit. , vol.14 , pp. 42-61
    • Demchenko, A.P.1
  • 5
    • 0030909685 scopus 로고    scopus 로고
    • The future is function
    • Fields S. 1997. The future is function. Nat. Genet. 15: 325-327.
    • (1997) Nat. Genet. , vol.15 , pp. 325-327
    • Fields, S.1
  • 6
    • 0033974688 scopus 로고    scopus 로고
    • Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
    • Ito T, Tashiro K, Muta S, Ozawa T, Chiba T, Nishizawa M, Yamamoto K, Kuhara S, Sakaki Y. 2000. Toward a protein-protein interaction map of the budding yeast: a comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc. Natl Acad. Sci. USA 97: 1143-1147.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1143-1147
    • Ito, T.1    Tashiro, K.2    Muta, S.3    Ozawa, T.4    Chiba, T.5    Nishizawa, M.6    Yamamoto, K.7    Kuhara, S.8    Sakaki, Y.9
  • 7
    • 0031569420 scopus 로고    scopus 로고
    • Angstroms and calories
    • Janin J. 1997. Angstroms and calories. Structure 5: 473-479.
    • (1997) Structure , vol.5 , pp. 473-479
    • Janin, J.1
  • 8
    • 0001895574 scopus 로고    scopus 로고
    • Mutational analysis of antibody binding sites
    • Van Regenmortel MHV (ed.). CRC Press: New York
    • Jin L, Wells JA. 1996. Mutational analysis of antibody binding sites. In Structure of Antigens, Vol. 3, Van Regenmortel MHV (ed.). CRC Press: New York; 21-36.
    • (1996) Structure of Antigens , vol.3 , pp. 21-36
    • Jin, L.1    Wells, J.A.2
  • 9
    • 0033226378 scopus 로고    scopus 로고
    • Survey of the 1998 optical biosensor literature
    • Myszka DG. 1999. Survey of the 1998 optical biosensor literature. J. Mol. Recognit. 12: 390-408.
    • (1999) J. Mol. Recognit. , vol.12 , pp. 390-408
    • Myszka, D.G.1
  • 10
    • 0002841275 scopus 로고    scopus 로고
    • BIA-MS-MS: Biomolecular interaction analysis for functional proteomics
    • Natsume T, Nakayama H, Isobe T. 2001. BIA-MS-MS: biomolecular interaction analysis for functional proteomics. Trends Biotechnol. 19: 528-533.
    • (2001) Trends Biotechnol. , vol.19 , pp. 528-533
    • Natsume, T.1    Nakayama, H.2    Isobe, T.3
  • 11
    • 0035524481 scopus 로고    scopus 로고
    • Biomolecular interaction analysis mass spectrometry
    • Nedelkov D, Nelson RW. 2001. Biomolecular interaction analysis mass spectrometry. Proteomics 1: 1441-1446.
    • (2001) Proteomics , vol.1 , pp. 1441-1446
    • Nedelkov, D.1    Nelson, R.W.2
  • 14
    • 0033667738 scopus 로고    scopus 로고
    • Survey of the 1999 surface plasmon resonance biosensor literature
    • Rich RL, Myszka DG. 2000. Survey of the 1999 surface plasmon resonance biosensor literature. J. Mol. Recognit. 13: 388-407.
    • (2000) J. Mol. Recognit. , vol.13 , pp. 388-407
    • Rich, R.L.1    Myszka, D.G.2
  • 15
    • 0035152823 scopus 로고    scopus 로고
    • Survey of the year 2000 commercial optical biosensor literature
    • Rich RL, Myszka DG. 2001. Survey of the year 2000 commercial optical biosensor literature. J. Mol. Recognit. 14: 273-294.
    • (2001) J. Mol. Recognit. , vol.14 , pp. 273-294
    • Rich, R.L.1    Myszka, D.G.2
  • 18
    • 0034055114 scopus 로고    scopus 로고
    • Are there two distinct research strategies for developing biologically active molecules: Rational design and empirical selection?
    • Van Regenmortel MHV. 2000. Are there two distinct research strategies for developing biologically active molecules: rational design and empirical selection? J. Mol. Recognit. 13: 1-4.
    • (2000) J. Mol. Recognit. , vol.13 , pp. 1-4
    • Van Regenmortel, M.H.V.1
  • 19
    • 0034974511 scopus 로고    scopus 로고
    • Analysing structure-function relationships with biosensors
    • Van Regenmortel MHV. 2001. Analysing structure-function relationships with biosensors. Cell. Mol Life Sci. 58: 794-800.
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 794-800
    • Van Regenmortel, M.H.V.1
  • 21
    • 0036760872 scopus 로고    scopus 로고
    • Reductionism and the search for structure-function relationships in antibody molecules
    • Van Regenmortel MHV. 2002b. Reductionism and the search for structure-function relationships in antibody molecules. J. Mol. Recognit. 15: 240-247.
    • (2002) J. Mol. Recognit. , vol.15 , pp. 240-247
    • Van Regenmortel, M.H.V.1
  • 22
    • 0037088751 scopus 로고    scopus 로고
    • Analysing biomolecular interactions
    • Wilson WD. 2002. Analysing biomolecular interactions. Science 295: 2103-2104.
    • (2002) Science , vol.295 , pp. 2103-2104
    • Wilson, W.D.1
  • 23
    • 0032722542 scopus 로고    scopus 로고
    • Active concentration measurements of recombinant biomolecules using biosensor technology
    • Zeder-Lutz G, Benito A, Van Regenmortel MHV. 1999. Active concentration measurements of recombinant biomolecules using biosensor technology. J. Mol. Recognit. 12: 300-309.
    • (1999) J. Mol. Recognit. , vol.12 , pp. 300-309
    • Zeder-Lutz, G.1    Benito, A.2    Van Regenmortel, M.H.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.