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0346994560
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The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: Experience with the STn-KLH vaccine (Theratope®)
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Holmberg LA, Oparin DV, Gooley T, Sandmaier BM. The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: experience with the STn-KLH vaccine (Theratope®). Clin Breast Cancer 2003; 3:S144-S151. This report describes antibody and cellular responses to STn-KLH vaccination following high-dose chemotherapy and stem cell rescue.
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Holmberg, L.A.1
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Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer
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Mobus VJ, Baum RP, Bolle M, et al. Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer. Am J Obstet Gynecol 2003; 189:28-36. This paper describes a clinical trial with a CA125-specific mouse MAb in patients with advanced stage ovarian cancer. The authors report a strong correlation between human anti-mouse antibody responses and improvement in overall survival (22.6 months in responders versus 7.2 months in nonresponders).
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Am J Obstet Gynecol
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Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: Immune responses and survival in palliative treatment
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Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient
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Knutson KL, Disis ML. Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient. Hum Immunol 2002; 63:547-557. This paper describes the diversity of T-cell responses in an ovarian cancer patient vaccinated with HER2/neu peptides that incorporate both helper T-cell and CTL epitopes.
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Hum Immunol
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Disis ML, Gooley TA, Rinn K, et al. Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol 2002; 20:2624-2632. An important paper describing the immunogenicity of HER2/neu peptide vaccination in patients with stage III or stage IV ovarian, breast, or non-small cell lung cancer: a notable finding is that the majority of vaccinees showed evidence of epitope spreading, that is an immune response to epitopes other than those present in the vaccine formulation.
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J Clin Oncol
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Disis, M.L.1
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TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
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Schlienger K, Chu CS, Woo EY, et al. TRANCE-and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin Cancer Res 2003; 9:1517-1527. This study uses a novel technique for dendritic cell maturation, and supports earlier reports that tumor antigen-pulsed dendritic cells can stimulate CTL responses against autologous ovarian tumor cells (see Refs [11-13]).
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Clin Cancer Res
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Schlienger, K.1
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+ cytotoxic T lymphocytes by ovarian tumor antigen-pulsed autologous dendritic cells from patients with advanced ovarian cancer
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+ cytotoxic T lymphocytes by ovarian tumor antigen-pulsed autologous dendritic cells from patients with advanced ovarian cancer. Am J Obstet Gynecol 2000; 183:601-609.
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+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells
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+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells. Obstet Gynecol 2000; 96:422-430.
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Induction of T cell responses against autologous ovarian tumors with whole tumor cell lysate-pulsed dendritic cells
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Zhao X, Wei YQ, Peng ZL. Induction of T cell responses against autologous ovarian tumors with whole tumor cell lysate-pulsed dendritic cells. Immunol Invest 2001; 30:33-45.
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Vaccination of melanoma patients with peptide or tumor lysate-pulsed dendritic cells
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Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
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Brossart P, Wirths S, Stuhler G, et al. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000; 96:3102-3108.
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Cannon MJ, O'Brien TJ, Underwood LJ, et al. Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer. Exp Rev Anticancer Therapy 2002; 2:97-105. This review provides a comprehensive account of an important series of novel serine protease and matrix metalloprotease antigens overexpressed by ovarian tumors.
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Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines
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Duan Z, Duan Y, Lamendola DE, et al. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. Clin Cancer Res 2003; 9:2778-2785. A remarkable study showing that MAGE and GAGE antigens are overexpressed by drug-resistant ovarian tumor cells, and that these antigens may play a role in the drug-resistant phenotype. These results also point to MAGE and GAGE as potential target antigens for immunotherapy of ovarian cancer.
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Clin Cancer Res
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Duan, Z.1
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Serologic analysis of ovarian tumor antigens reveals a bias towards antigens encoded on 17q
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Stone B, Schummer M, Paley PJ, et al. Serologic analysis of ovarian tumor antigens reveals a bias towards antigens encoded on 17q. Int J Cancer 2003; 104:73-84. An important study that illustrates the power of SEREX analysis for identification of immunogenic tumor antigens.
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Int J Cancer
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Stone, B.1
Schummer, M.2
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The CA125 gene: An extracellular superstructure dominated by repeat sequences
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O'Brien TJ, Beard JB, Underwood LJ, et al. The CA125 gene: an extracellular superstructure dominated by repeat sequences. Tumour Biol 2001; 22:348-366.
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Yin BWT, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen. J Biol Chem 2001; 276:27371-27375.
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O'Brien TJ, Beard JB, Underwood LJ, Shigemasa K. The CA125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumour Biol 2002; 23:154-169. The latest, and most probably definitive, report on the sequence and protein backbone of CA125, following two other major reports on cloning and sequencing of CA125 (Refs [19,20]).
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Tumour Biol
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Kui Wong N, Easton RL, Panico M, et al. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. J Biol Chem 2003; 278:28619-28634. A comprehensive and highly detailed analysis of carbohydrate structures on CA125. This study highlights potential structure-function relationships, including a proposed role of CA125 in modulation of natural killer and T-cell function.
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Mitchell DA, Fadden AJ, Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. J Biol Chem 2001; 276:28939-28945.
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x glycan (also present on CA125) binds DC-SIGN expressed on dendritic cells.
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Glycobiology
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Van Kooyk Y, Geijtenbeek TBH. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev 2002; 186:47-56. This review provides a comprehensive account of the role of the C-type lectin DC-SIGN in dendritic cell trafficking and T-cell interactions.
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Schuler G, Schuler-Thumer B, Steinman RM. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003; 15:138-147. A thorough account of dendritic cell technology and tumor immunotherapy. The authors appreciate the challenges of dendritic cell-based vaccination, but offer a strong advocacy of this approach.
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Curr Opin Immunol
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Schuler, G.1
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