메뉴 건너뛰기




Volumn 16, Issue 1, 2004, Pages 87-92

Immunological treatment of ovarian cancer

Author keywords

CA125; Dendritic cells; Immunotherapy; Ovarian cancer; Vaccination

Indexed keywords

ANTINEOPLASTIC AGENT; CA 125 ANTIGEN; CANCER VACCINE; CARBOHYDRATE ANTIGEN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPSIN; IDIOTYPIC ANTIBODY; KALLIKREIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C MOV18; MUCIN 1; MURINE MONOCLONAL ANTIBODY B43.13; MURINE MONOCLONAL IDIOTYPIC ANTIBODY ACA125; NEUROPSIN; PACLITAXEL; PEPTIDE; PROTEIN P53; SERINE PROTEINASE; SIALYL TN KEYHOLE LIMPET HEMOCYANIN CONJUGATE VACCINE; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; TESTISIN; THERATOPE; TRASTUZUMAB; TUMOR ANTIGEN; TUMOR ASSOCIATED DIFFERENTIALLY EXPRESSED GENE PRODUCT 12; TUMOR ASSOCIATED DIFFERENTIALLY EXPRESSED GENE PRODUCT 14; TUMOR ASSOCIATED DIFFERENTIALLY EXPRESSED GENE PRODUCT 15; TUMOR ASSOCIATED DIFFERENTIALLY EXPRESSED GENE PRODUCT 16; UNCLASSIFIED DRUG;

EID: 1242294500     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001703-200402000-00015     Document Type: Review
Times cited : (23)

References (32)
  • 1
    • 0346994560 scopus 로고    scopus 로고
    • The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: Experience with the STn-KLH vaccine (Theratope®)
    • Holmberg LA, Oparin DV, Gooley T, Sandmaier BM. The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: experience with the STn-KLH vaccine (Theratope®). Clin Breast Cancer 2003; 3:S144-S151. This report describes antibody and cellular responses to STn-KLH vaccination following high-dose chemotherapy and stem cell rescue.
    • (2003) Clin Breast Cancer , vol.3
    • Holmberg, L.A.1    Oparin, D.V.2    Gooley, T.3    Sandmaier, B.M.4
  • 3
    • 0038336598 scopus 로고    scopus 로고
    • Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer
    • Mobus VJ, Baum RP, Bolle M, et al. Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer. Am J Obstet Gynecol 2003; 189:28-36. This paper describes a clinical trial with a CA125-specific mouse MAb in patients with advanced stage ovarian cancer. The authors report a strong correlation between human anti-mouse antibody responses and improvement in overall survival (22.6 months in responders versus 7.2 months in nonresponders).
    • (2003) Am J Obstet Gynecol , vol.189 , pp. 28-36
    • Mobus, V.J.1    Baum, R.P.2    Bolle, M.3
  • 4
    • 0034900191 scopus 로고    scopus 로고
    • Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: Immune responses and survival in palliative treatment
    • Wagner U, Kohler S, Reinartz S, et al. Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses and survival in palliative treatment. Clin Cancer Res 2001; 7:1154-1162.
    • (2001) Clin Cancer Res , vol.7 , pp. 1154-1162
    • Wagner, U.1    Kohler, S.2    Reinartz, S.3
  • 5
    • 0036380518 scopus 로고    scopus 로고
    • Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: A pilot study
    • Van Zanten-Przybysz I, Molthoff C, Gebbinck JK, et al. Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study. J Cancer Res Clin Oncol 2002; 128:484-492.
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 484-492
    • Van Zanten-Przybysz, I.1    Molthoff, C.2    Gebbinck, J.K.3
  • 6
    • 0035985418 scopus 로고    scopus 로고
    • Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient
    • Knutson KL, Disis ML. Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient. Hum Immunol 2002; 63:547-557. This paper describes the diversity of T-cell responses in an ovarian cancer patient vaccinated with HER2/neu peptides that incorporate both helper T-cell and CTL epitopes.
    • (2002) Hum Immunol , vol.63 , pp. 547-557
    • Knutson, K.L.1    Disis, M.L.2
  • 7
    • 0036605567 scopus 로고    scopus 로고
    • Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
    • Disis ML, Gooley TA, Rinn K, et al. Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol 2002; 20:2624-2632. An important paper describing the immunogenicity of HER2/neu peptide vaccination in patients with stage III or stage IV ovarian, breast, or non-small cell lung cancer: a notable finding is that the majority of vaccinees showed evidence of epitope spreading, that is an immune response to epitopes other than those present in the vaccine formulation.
    • (2002) J Clin Oncol , vol.20 , pp. 2624-2632
    • Disis, M.L.1    Gooley, T.A.2    Rinn, K.3
  • 10
    • 0037388367 scopus 로고    scopus 로고
    • TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
    • Schlienger K, Chu CS, Woo EY, et al. TRANCE-and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin Cancer Res 2003; 9:1517-1527. This study uses a novel technique for dendritic cell maturation, and supports earlier reports that tumor antigen-pulsed dendritic cells can stimulate CTL responses against autologous ovarian tumor cells (see Refs [11-13]).
    • (2003) Clin Cancer Res , vol.9 , pp. 1517-1527
    • Schlienger, K.1    Chu, C.S.2    Woo, E.Y.3
  • 11
    • 0033829658 scopus 로고    scopus 로고
    • + cytotoxic T lymphocytes by ovarian tumor antigen-pulsed autologous dendritic cells from patients with advanced ovarian cancer
    • + cytotoxic T lymphocytes by ovarian tumor antigen-pulsed autologous dendritic cells from patients with advanced ovarian cancer. Am J Obstet Gynecol 2000; 183:601-609.
    • (2000) Am J Obstet Gynecol , vol.183 , pp. 601-609
    • Santin, A.D.1    Hermonat, P.L.2    Ravaggi, A.3
  • 12
    • 0034734986 scopus 로고    scopus 로고
    • + cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells
    • + cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells. Obstet Gynecol 2000; 96:422-430.
    • (2000) Obstet Gynecol , vol.96 , pp. 422-430
    • Santin, A.D.1    Bellone, S.2    Ravaggi, A.3
  • 13
    • 0034962599 scopus 로고    scopus 로고
    • Induction of T cell responses against autologous ovarian tumors with whole tumor cell lysate-pulsed dendritic cells
    • Zhao X, Wei YQ, Peng ZL. Induction of T cell responses against autologous ovarian tumors with whole tumor cell lysate-pulsed dendritic cells. Immunol Invest 2001; 30:33-45.
    • (2001) Immunol Invest , vol.30 , pp. 33-45
    • Zhao, X.1    Wei, Y.Q.2    Peng, Z.L.3
  • 14
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide or tumor lysate-pulsed dendritic cells
    • Nestlé FO, Alijagic S, Gilliet M, et al. Vaccination of melanoma patients with peptide or tumor lysate-pulsed dendritic cells. Nat Med 1998; 4:328-332.
    • (1998) Nat Med , vol.4 , pp. 328-332
    • Nestlé, F.O.1    Alijagic, S.2    Gilliet, M.3
  • 15
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart P, Wirths S, Stuhler G, et al. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000; 96:3102-3108.
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3
  • 16
    • 0036088918 scopus 로고    scopus 로고
    • Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer
    • Cannon MJ, O'Brien TJ, Underwood LJ, et al. Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer. Exp Rev Anticancer Therapy 2002; 2:97-105. This review provides a comprehensive account of an important series of novel serine protease and matrix metalloprotease antigens overexpressed by ovarian tumors.
    • (2002) Exp Rev Anticancer Therapy , vol.2 , pp. 97-105
    • Cannon, M.J.1    O'Brien, T.J.2    Underwood, L.J.3
  • 17
    • 0037625216 scopus 로고    scopus 로고
    • Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines
    • Duan Z, Duan Y, Lamendola DE, et al. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. Clin Cancer Res 2003; 9:2778-2785. A remarkable study showing that MAGE and GAGE antigens are overexpressed by drug-resistant ovarian tumor cells, and that these antigens may play a role in the drug-resistant phenotype. These results also point to MAGE and GAGE as potential target antigens for immunotherapy of ovarian cancer.
    • (2003) Clin Cancer Res , vol.9 , pp. 2778-2785
    • Duan, Z.1    Duan, Y.2    Lamendola, D.E.3
  • 18
    • 0037430144 scopus 로고    scopus 로고
    • Serologic analysis of ovarian tumor antigens reveals a bias towards antigens encoded on 17q
    • Stone B, Schummer M, Paley PJ, et al. Serologic analysis of ovarian tumor antigens reveals a bias towards antigens encoded on 17q. Int J Cancer 2003; 104:73-84. An important study that illustrates the power of SEREX analysis for identification of immunogenic tumor antigens.
    • (2003) Int J Cancer , vol.104 , pp. 73-84
    • Stone, B.1    Schummer, M.2    Paley, P.J.3
  • 19
    • 0035689033 scopus 로고    scopus 로고
    • The CA125 gene: An extracellular superstructure dominated by repeat sequences
    • O'Brien TJ, Beard JB, Underwood LJ, et al. The CA125 gene: an extracellular superstructure dominated by repeat sequences. Tumour Biol 2001; 22:348-366.
    • (2001) Tumour Biol , vol.22 , pp. 348-366
    • O'Brien, T.J.1    Beard, J.B.2    Underwood, L.J.3
  • 20
    • 0035920171 scopus 로고    scopus 로고
    • Molecular cloning of the CA125 ovarian cancer antigen
    • Yin BWT, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen. J Biol Chem 2001; 276:27371-27375.
    • (2001) J Biol Chem , vol.276 , pp. 27371-27375
    • Yin, B.W.T.1    Lloyd, K.O.2
  • 21
    • 0036560755 scopus 로고    scopus 로고
    • The CA125 gene: A newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure
    • O'Brien TJ, Beard JB, Underwood LJ, Shigemasa K. The CA125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumour Biol 2002; 23:154-169. The latest, and most probably definitive, report on the sequence and protein backbone of CA125, following two other major reports on cloning and sequencing of CA125 (Refs [19,20]).
    • (2002) Tumour Biol , vol.23 , pp. 154-169
    • O'Brien, T.J.1    Beard, J.B.2    Underwood, L.J.3    Shigemasa, K.4
  • 22
    • 0042206865 scopus 로고    scopus 로고
    • Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125
    • Kui Wong N, Easton RL, Panico M, et al. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. J Biol Chem 2003; 278:28619-28634. A comprehensive and highly detailed analysis of carbohydrate structures on CA125. This study highlights potential structure-function relationships, including a proposed role of CA125 in modulation of natural killer and T-cell function.
    • (2003) J Biol Chem , vol.278 , pp. 28619-28634
    • Kui Wong, N.1    Easton, R.L.2    Panico, M.3
  • 23
    • 0028972248 scopus 로고
    • Glycophorin a protects K562 cells from natural killer cell attack
    • El Ouagari K, Teissié J, Benoist H. Glycophorin A protects K562 cells from natural killer cell attack. J Biol Chem 1995; 270:26970-26975.
    • (1995) J Biol Chem , vol.270 , pp. 26970-26975
    • El Ouagari, K.1    Teissié, J.2    Benoist, H.3
  • 24
    • 0035800757 scopus 로고    scopus 로고
    • A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR
    • Mitchell DA, Fadden AJ, Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. J Biol Chem 2001; 276:28939-28945.
    • (2001) J Biol Chem , vol.276 , pp. 28939-28945
    • Mitchell, D.A.1    Fadden, A.J.2    Drickamer, K.3
  • 25
    • 0037942767 scopus 로고    scopus 로고
    • The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x
    • x glycan (also present on CA125) binds DC-SIGN expressed on dendritic cells.
    • (2003) Glycobiology , vol.13 , pp. 471-478
    • Van Die, I.1    Van Vliet, S.J.2    Nyame, A.K.3
  • 26
    • 0036696154 scopus 로고    scopus 로고
    • A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions
    • Van Kooyk Y, Geijtenbeek TBH. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev 2002; 186:47-56. This review provides a comprehensive account of the role of the C-type lectin DC-SIGN in dendritic cell trafficking and T-cell interactions.
    • (2002) Immunol Rev , vol.186 , pp. 47-56
    • Van Kooyk, Y.1    Geijtenbeek, T.B.H.2
  • 27
    • 0037237593 scopus 로고    scopus 로고
    • Mycobactena target DC SIGN to suppress dendritic cell function
    • Geijtenbeek TB, Van Vliet SJ, Koppel EA, et al. Mycobactena target DC SIGN to suppress dendritic cell function. J Exp Med 2003; 197:7-17. The mycobacterial mannose-based oligosaccharide lipoarabinomannan binds to DC-SIGN (which specifically interacts with α-D-mannoses) and blocks dendritic cell maturation. This is important in the context of ovarian cancer because the N-terminus of CA125 is rich in high mannose N-glycans, suggesting a possible mechanism for CA125 to subvert dendritic cell function and ovarian tumor-specific immune responses.
    • (2003) J Exp Med , vol.197 , pp. 7-17
    • Geijtenbeek, T.B.1    Van Vliet, S.J.2    Koppel, E.A.3
  • 28
    • 0037383703 scopus 로고    scopus 로고
    • The cancer antigen CA125 represents a novel counter receptor for galectin-1
    • Sellenmeyer C, Wegehingel S, Lechner J, Nickel W. The cancer antigen CA125 represents a novel counter receptor for galectin-1. J Cell Sci 2003; 116:1305-1318. CA125 binds galectin-1, and may play a key role as a chaperone for cell surface expression of galectin-1. This is a high impact report, because galectin-1 is well known for its ability to induce apoptosis in activated T cells (see Refs [29-31]).
    • (2003) J Cell Sci , vol.116 , pp. 1305-1318
    • Sellenmeyer, C.1    Wegehingel, S.2    Lechner, J.3    Nickel, W.4
  • 29
    • 0033555408 scopus 로고    scopus 로고
    • Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation
    • Vespa GN, Lewis LA, Kozak KR, et al. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. J Immunol 1999; 162:799-806.
    • (1999) J Immunol , vol.162 , pp. 799-806
    • Vespa, G.N.1    Lewis, L.A.2    Kozak, K.R.3
  • 30
    • 0034267915 scopus 로고    scopus 로고
    • CD7 delivers a pro-apoptotic signal during galectin-1-induced cell death
    • Pace KE, Hahn HP, Pang M et al. CD7 delivers a pro-apoptotic signal during galectin-1-induced cell death. J Immunol 2000; 165:2331-2334.
    • (2000) J Immunol , vol.165 , pp. 2331-2334
    • Pace, K.E.1    Hahn, H.P.2    Pang, M.3
  • 31
    • 0035889895 scopus 로고    scopus 로고
    • CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans
    • Nguyen JT, Evans DP, Galvan M, et al. CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J Immunol 2001; 167:5697-5707.
    • (2001) J Immunol , vol.167 , pp. 5697-5707
    • Nguyen, J.T.1    Evans, D.P.2    Galvan, M.3
  • 32
    • 0037375713 scopus 로고    scopus 로고
    • The use of dendritic cells in cancer immunotherapy
    • Schuler G, Schuler-Thumer B, Steinman RM. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003; 15:138-147. A thorough account of dendritic cell technology and tumor immunotherapy. The authors appreciate the challenges of dendritic cell-based vaccination, but offer a strong advocacy of this approach.
    • (2003) Curr Opin Immunol , vol.15 , pp. 138-147
    • Schuler, G.1    Schuler-Thumer, B.2    Steinman, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.