Melanin protects melanocytes and keratinocytes against H2O 2-induced DNA strand breaks through its ability to bind Ca 2+

Experimental Cell Research

Volumn 294, Issue 1, 2004, Pages 60-67

  Hoogduijn, M J ^a,c   Cemeli, E ^a   Ross, K ^b   Anderson, D ^a   Thody, A J ^a,b   Wood, J M ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

BAPTA; Calcium; Comet assay; DNA damage; H2O2; Keratinocyte; Melanin; Melanocyte

Indexed keywords

CALCIUM CHELATING AGENT; CALCIUM ION; DNA; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; HYDROGEN PEROXIDE; MELANIN;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CALCIUM HOMEOSTASIS; CAUCASIAN; CELL PROTECTION; COMET ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA STRAND; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

EID: 1242294406     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2003.11.007     Document Type: Article

References (46)

1. Kobayashi N., Nakagawa A., Muramatsu T., Yamashina Y., Shirai T., Hashimoto M.W., Ishigaki Y., Ohnishi T., Mori T. Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis. J. Invest. Dermatol. 110:1998;806-810.
2. Wood J.M., Jimbow K., Boissy R.E., Slominski A., Plonka P.M., Slawinski J., Wortsman J., Tosk J. What's the use of generating melanin? Exp. Dermatol. 8:1999;153-164.
3. Hill H.Z. The function of melanin or six blind people examine an elephant. Bioessays. 14:1992;49-56.
4. Kobayashi N., Muramatsu T., Yamashina Y., Shirai T., Ohnishi T., Mori T. Melanin reduces ultraviolet-induced DNA damage formation and killing rate in cultured human melanoma cells. J. Invest. Dermatol. 101:1993;685-689.
5. Kollias N., Malallah Y.H., al Ajmi H., Baqer A., Johnson B.E., Gonzalez S. Erythema and melanogenesis action spectra in heavily pigmented individuals as compared to fair-skinned Caucasians. Photodermatol. Photoimmunol. Photomed. 12:1996;183-188.
6. Li W., Hill H.Z. Induced melanin reduces mutations and cell killing in mouse melanoma. Photochem. Photobiol. 65:1997;480-485.
7. Lock-Andersen J., Therkildsen P., de Fine O.F., Gniadecka M., Dahlstrom K., Poulsen T., Wulf H.C. Epidermal thickness, skin pigmentation and constitutive photosensitivity. Photodermatol. Photoimmunol. Photomed. 13:1997;153-158.
8. De Leeuw S.M., Smit N.P., Van Veldhoven M., Pennings E.M., Pavel S., Simons J.W., Schothorst A.A. Melanin content of cultured human melanocytes and UV-induced cytotoxicity. J. Photochem. Photobiol. B. 61:2001;106-113.
9. Smit N.P., Vink A.A., Kolb R.M., Steenwinkel M.J., van den Berg P.T., van Nieuwpoort F., Roza L., Pavel S. Melanin offers protection against induction of cyclobutane pyrimidine dimers and 6-4 photoproducts by UVB in cultured human melanocytes. Photochem. Photobiol. 74:2001;424-430.
10. Giles G.G., Marks R., Foley P. Incidence of non-melanocytic skin cancer treated in Australia. BMJ. 296:1988;13-17.
11. Gutteridge J.M., Halliwell B. Free radicals and antioxidants in the year 2000. A historical look to the future. Ann. N. Y. Acad. Sci. 899:2000;136-147.
12. Sarna T., Sealy R.C. Photoinduced oxygen consumption in melanin systems. Action spectra and quantum yields for eumelanin and synthetic melanin. Photochem. Photobiol. 39:1984;69-74.
13. Korytowski W., Kalyanaraman B., Menon I.A., Sarna T., Sealy R.C. Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. Biochim. Biophys. Acta. 882:1986;145-153.
14. Menter J.M., Patta A.M., Hollins T.D., Moore C.L., Willis I. Photoprotection of mammalian acid-soluble collagen by cuttlefish sepia melanin in vitro. Photochem. Photobiol. 68:1998;532-537.
15. Korytowski W., Hintz P., Sealy R.C., Kalyanaraman B. Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments. Biochem. Biophys. Res. Commun. 131:1985;659-665.
16. Sichel G. Biosynthesis and function of melanins in hepatic pigmentary system. Pigment Cell Res. 1:1988;250-258.
17. Tobin D., Thody A.J. The superoxide anion may mediate short- but not long-term effects of ultraviolet radiation on melanogenesis. Exp. Dermatol. 3:1994;99-105.
18. Wood J.M., Schallreuter K.U. Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols. Biochim. Biophys. Acta. 1074:1991;378-385.
19. Meyer zum Gottesberge A.M. Physiology and pathophysiology of inner ear melanin. Pigment Cell Res. 1:1988;238-249.
20. Szekeres L. Fine structure and x-ray microanalysis of melanosomes in pigmented nevi and melanomas. Arch. Dermatol. Forsch. 252:1975;297-304.
21. Potts A.M., Au P.C. The affinity of melanin for inorganic ions. Exp. Eye Res. 22:1976;487-491.
22. Salceda R., Sanchez-Chavez G. Calcium uptake, release and ryanodine binding in melanosomes from retinal pigment epithelium. Cell Calcium. 27:2000;223-229.
23. 2+-dependent DNA damage in human peripheral blood lymphocytes. Free Radic. Biol. Med. 26:1999;548-556.
24. Barbouti A., Doulias P.T., Zhu B.Z., Frei B., Galaris D. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage. Free Radic. Biol. Med. 31:2001;490-498.
25. 2 in islets of rats. Life Sci. 68:2000;475-481.
26. 2 in quiescent isolated rat cardiomyocytes. Basic Res. Cardiol. 6:2001;623-629.
27. 2+ release from osteoblast internal stores. Yonsei Med. J. 43:2003;229-235.
28. 2+ homeostasis in human melanocytes. Pigment Cell Res. 16:2003;127-132.
29. Smit N.P., Westerhof W., Menko W.J., Verbeek N.M., Pavel S. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. Pigment Cell Res. 8:1995;19-27.
30. Ancans J., Hoogduijn M.J., Thody A.J. Melanosomal pH, pink locus protein and their roles in melanogenesis. J. Invest. Dermatol. 117:2001;158-159.
31. Boukamp P., Petrussevska R.T., Breitkreutz D., Hornung J., Markham A., Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106:1988;761-771.
32. Straten T.P., Kirkin A.F., Seremet T., Zeuthen J. Expression of transporter associated with antigen processing 1 and 2 (TAP1/2) in malignant melanoma cell lines. Int. J. Cancer. 70:1997;582-586.
33. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
34. Pariente J.A., Camello C., Camello P.J., Salido G.M. Release of calcium from mitochondrial and nonmitochondrial intracellular stores in mouse pancreatic acinar cells by hydrogen peroxide. J. Membr. Biol. 179:2001;27-35.
35. Valverde P., Manning P., Todd C., McNeil C.J., Thody A.J. Tyrosinase may protect human melanocytes from the cytotoxic effects of the superoxide anion. Exp. Dermatol. 5:1996;247-253.
36. Furukawa F., Huff J.C., Lyons M.B., Weston W.L., Norris D.A. Characterization and practical benefits of keratinocytes cultured in strontium-containing serum-free medium. J. Invest. Dermatol. 90:1988;690-696.
37. Wenczl E., Van der Schans G.P., Roza L., Kolb R.M., Timmerman A.J., Smit N.P., Pavel S., Schothorst A.A. (Pheo)melanin photosensitizes UVA-induced DNA damage in cultured human melanocytes. J. Invest. Dermatol. 111:1998;678-682.
38. Vincensi M.R., d'Ischia M., Napolitano A., Procaccini E.M., Riccio G., Monfrecola G., Santoianni P., Prota G. Phaeomelanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma: a pilot study. Melanoma Res. 8:1998;53-58.
39. Ancans J., Tobin D.J., Hoogduijn M.J., Smit N.P., Wakamatsu K., Thody A.J. Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells. Exp. Cell Res. 268:2001;26-35.
40. Schallreuter K.U., Pittelkow M.R., Gleason F.K., Wood J.M. The role of calcium in the regulation of free radical reduction by thioredoxin reductase at the surface of the skin. J. Inorg. Biochem. 28:1986;227-238.
41. Schallreuter K.U., Pittelkow M.R., Wood J.M. EF-hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytes. Biochem. Biophys. Res. Commun. 162:1989;1311-1316.
42. Gitler C., Zarmi B., Kalef E., Meller R., Zor U., Goldman R. Calcium-dependent oxidation of thioredoxin during cellular growth initiation. Biochem. Biophys. Res. Commun. 290:2002;624-628.
43. Schallreuter K.U., Wood J.M. Thioredoxin reductase - Its role in epidermal redox status. J. Photochem. Photobiol. B. 64:2001;179-184.
44. Scoltock A.B., Bortner C.D., Bird J., Putney J.W., Cidlowski J.A. A selective requirement for elevated calcium in DNA degradation, but not early events in anti-Fas-induced apoptosis. J. Biol. Chem. 275:2000;30586-30596.
45. Ermak G., Davies K.J. Calcium and oxidative stress: from cell signaling to cell death. Mol. Immunol. 38:2002;713-721.
46. Schallreuter K.U., Wood J.M. The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes. Biochem. Biophys. Res. Commun. 262:1999;423-428.