Phaeomelanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma: A pilot study

Melanoma Research

Volumn 8, Issue 1, 1998, Pages 53-58

  Vincensi, M R ^a   D'Ischia, M ^a   Napolitano, A ^a   Procaccini, E M ^a   Riccio, G ^a   Monfrecola, G ^a   Santoianni, P ^a   Prota, G ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Eumelanin; Melanoma risk; Phaeomelanin; Red hair; Ultraviolet susceptibility

Indexed keywords

EUMELANIN; PHEOMELANIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER RISK; CLINICAL ARTICLE; COLORIMETRY; FEMALE; HAIR ANALYSIS; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MELANOMA; PHOTOSENSITIVITY; PREDICTION; PRIORITY JOURNAL; SKIN PIGMENTATION; SKIN SENSITIVITY; ULTRAVIOLET RADIATION;

ADULT; BIOLOGICAL MARKERS; FEMALE; HAIR; HAIR COLOR; HUMANS; MALE; MELANINS; MELANOMA; MIDDLE AGED; PHOTOSENSITIVITY DISORDERS; PILOT PROJECTS; RISK FACTORS; SKIN; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0031940949     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-199802000-00009     Document Type: Article

References (24)

1. Elwood JM, Whitehead SM, Davison J, et al. Malignant melanoma in England: risks associated with naevi, freckles, social class, hair colour and sunburn. Int J Epidemiol 1990; 19: 801-810.
2. Bliss JM, Ford D, Swerdlow AJ, et al. Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE). Int J Cancer 1995; 62: 367-376.
3. Elwood JM, Gallagher RP, Hill GB, et al. Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma. Western Canada Melanoma Study. BMJ 1984; 288: 99-102.
4. Prota G. Melanins and Melanogenesis. San Diego: Academic Press, 1992.
5. Quevedo WC Jr, Fitzpatrick TB, Pathak MA, et al. Light and skin color. In: Fitzpatrick TB, Pathak MA, Herber LC, Seiji M, Kukita A, eds. Sunlight and Man. Tokyo: University of Tokyo Press, 1974: 165-194.
6. Thody AJ, Higgins EM, Wakamatsu K, et al. Pheomelanin as well as eumelanin is present in human epidermis. J Invest Dermatol 1991; 97: 340-344.
7. Chedekel MR, Photophysics and photochemistry of melanin. In: Zeise L, Chedekel MR, Fitzpatrick TB, eds. Melanin: Its Role in Human Photoprotection. Overland Park, Kansas: Valdenmar Publishing Company, 1995: 11-23.
8. Chedekel MR, Smith SK, Post PW, et al. Photodestruction of pheomelanin: role of oxygen. Proc Natl Acad Sci USA 1978; 75: 5396-5399.
9. Chedekel MR, Post PW, Deibel RM, et al. Photodestruction of pheomelanin. Photochem Photobiol 1977; 26: 651-653.
10. Chedekel MR. Photochemistry and photobiology of epidermal melanins. Photochem Photobiol 1982; 35: 881-885.
11. Prota G. Regulatory mechanism of melanogenesis: beyond the tyrosinase concept. J Infest Dermatol 1993; 100: 156S-161S.
12. Ito S, Fujita K. Microanalysis of eumelanin and pheomelanin in hair and melanosomas by chemical degradation and liquid chromatography. Anal Biochem 1985; 144: 527-536.
13. Ito S, Jimbow K. Quantitative analysis of eumelanin and pheomelanin in hair and melanomas. J Invest Dermatol 1983; 80: 268-272.
14. Napolitano S, Pezzella A, Vincensi MR, et al. Oxidative degradation of melanins to pyrrole acids: a model study. Tetrahedron 1995; 51: 5913-5920.
15. Prota G, Lamoreux ML, Muller J, et al. Comparative analysis of melanins and melanosomes produced by various coat color mutants. Pigment Cell Res 1995; 8: 153-163.
16. Sorocco M, Nicolaus RA. Acido 2,3,4,5-pirroltetracarbonico nell'ossidazione della melanina di seppia. Rend Acad Naz Lincei 1956; 22: 795.
17. McKinley AF, Diffey BL. A reference action spectrum for ultraviolet-induced erythema in human skin. In: Passchier WF, Bosnjakowich BFM, eds. Human Exposure to UV Radiations: risk and regulation. Proceedings of a seminar held in Amsterdam, March 23-25, 1987. Amsterdam: Excerpta Medica, 1987: 83-97.
18. Seitz JC, Claire G, Whitmore CG. Measurement of erythema and tanning responses in human skin using a tristimulus colorimeter. Dermatologica 1988; 177: 70-75.
19. Jimbow K, Lee SK, King MG, et al. Melanin pigments and melanosomal proteins as differentiation markers unique to normal and neoplastic melanocytes. J Invest Dermatol 1993; 100: 259S-268S.
20. Prota G, Misuraca G. Melanins, melanogenesis and skin photoprotection. Melanoma Res 1996; 6: S4-S5.
21. Valverde P, Healey E, Jackson I, et al. Variants of the melanocyte stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nature Genetics 1995; 11: 328-330.
22. Streilen JW, Taylor JR, Vincek V, et al. Relationship between ultraviolet radiation-induced immunosuppression and carcinogenesis. J Invest Dermatol 1994; 103: 107S-111S.
23. Prota G. Misuraca G. Melanin-related metabolites: a new look at their functional role. In: Hori Y, Hearing VJ, Nakayama J, eds. Melanogenesis and Malignant Melanoma: biochemistry, cell biology, molecular biology, pathophysiology, diagnosis and treatment. Amsterdam: Excerpta Medica, 1996: 49-61.
24. Schmitz S, Panakkezhum DT, Allen TM, et al. Dual role of melanins and melanin precursors as photopratective and phototoxic agents: inhibition of ultraviolet radiation-induced lipid peroxidation. Photochem Photobiol 1995; 61: 650-655.