Characterization of the ultraviolet B and X-ray response of primary cultured epidermal cells from patients with disseminated superficial actinic porokeratosis

British Journal of Dermatology

Volumn 150, Issue 1, 2004, Pages 47-55

  D'Errico, M ^a   Teson, M ^b   Calcagnile, A ^a   Corona, R ^b   Didona, B ^b   Meschini, R ^c   Zambruno, G ^b   Dogliotti, E ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c UNIVERSITY OF TUSCIA   (Italy)

Author keywords

Apoptosis; Differentiation; Disseminated superficial actinic porokeratosis; Keratinocytes; Ultraviolet B; X rays

Indexed keywords

FILAGGRIN; MUTANT PROTEIN; PROTEIN P53;

ACTINIC POROKERATOSIS; ADULT; AGED; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOTOXICITY; DNA SEQUENCE; EPIDERMIS CELL; FIBROBLAST; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERSENSITIVITY; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; SKIN CULTURE; ULTRAVIOLET B RADIATION; X RAY;

ADULT; AGED; APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CHILD; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPIDERMIS; FIBROBLASTS; GENES, P53; HUMANS; KERATINOCYTES; MIDDLE AGED; MUTATION; POROKERATOSIS; ULTRAVIOLET RAYS;

EID: 1242275311     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.05714.x     Document Type: Article

References (26)

1. Chernosky ME, Freeman RG. Disseminated superficial actinic porokeratosis (DSAP). Arch Dermatol 1967; 96: 611-24.
2. Watanabe R, Otsuka F. Cultured skin fibroblasts derived from three patients with disseminated superficial actinic porokeratosis (DSAP) are hypersensitive to the lethal effects of X-radiation but not to those of ultraviolet (UV) light. Exp Dermatol 1993; 2: 175-8.
3. Magee JW, McCalmont TH, LeBoit PE. Overexpression of p53 tumor suppressor protein in porokeratosis. Arch Dermatol 1994; 130: 187-90.
4. Urano Y, Sasaki S, Ninomiya Y et al. Immunohistochemical detection of p53 tumor suppressor protein in porokeratosis. J Dermatol 1996; 23: 365-8.
5. Nelson C, Cowper S, Morgan M. p53, mdm-2, and p21 waf-1 in the porokeratoses. Am J Dermatopathol 1999; 21: 420-5.
6. Happle R. Cancer proneness of linear porokeratosis may be explained by allelic loss. Dermatology 1997; 195: 20-5.
7. Xia JH, Yang YF, Deng H et al. Identification of a locus for disseminated superficial actinic porokeratosis at chromosome 12q23.2-24.1. J Invest Dermatol 2000; 114: 1071-4.
8. Xia K, Deng H, Xia JH et al. A novel locus (DSAP2) for disseminated superficial actinic porokeratosis maps to chromosome 15q25.1-26.1. Br J Dermatol 2002; 147: 650-4.
9. D'Errico M, Calcagnile AS, Corona R et al. p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age. Cancer Res 1997; 57: 747-52.
10. Zambruno G, Marchisio PC, Marconi A et al. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J Cell Biol 1995; 129: 853-65.
11. Regnier M, Scheizer J, Michel S et al. Expression of high molecular weight (67K) keratin in human keratinocytes cultured on dead de-epidermized dermis. Exp Cell Res 1986; 165: 63-72.
12. Barrandon Y, Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci USA 1987; 84: 2302-6.
13. Kanitakis J, Zambruno G, Viac J et al. Expression of an estrogen receptor-associated protein (p29) in epithelial tumors of the skin. J Cutan Pathol 1989; 16: 272-6.
14. Missero C, D'Errico MR, Dotto GP et al. The Molecular Basis of Skin Carcinogenesis. Totowa, NJ: Humana Press. 2002.
15. Otto AI, Riou L, Marionnet C et al. Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients. Cancer Res 1999; 59: 1212-8.
16. D'Errico M, Teson M, Calcagnile A et al. Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death Differ 2003; 10: 754-6.
17. Wrone-Smith T, Mitra RS, Thompson CB et al. Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am J Pathol 1997; 151: 1321-9.
18. Fuchs E, Byrne C. The epidermis: rising to the surface. Curr Opin Genet Dev 1994; 4: 725-36.
19. Dogliotti E, Hainaut P, Hernandez T et al. Mutation spectra resulting from carcinogenic exposure: from model systems to cancer-related genes. Recent Results Cancer Res 1998; 154: 97-124.
20. Giglia-Mari G, Sarasin A. TP53 mutations in human skin cancers. Hum Mutat 2003; 21: 217-28.
21. Ninomiya Y, Urano Y, Yoshimoto K et al. p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma. J Dermatol Sci 1997; 14: 173-8.
22. Kraemer KH. Lessons learned from xeroderma pigmentosum. Photochem Photobiol 1996; 63: 420-2.
23. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3: 155-68.
24. Gandarillas A. Epidermal differentiation, apoptosis, and senescence: common pathways? Exp Gerontol 2000; 35: 53-62.
25. Shen CS, Tabata K, Matsuki M et al. Premature apoptosis of keratinocytes and the dysregulation of keratinization in porokeratosis. Br J Dermatol 2002; 147: 498-502.
26. Gray MH, Smoller BS, McNutt NS. Carcinogenesis in porokeratosis. Evidence for a role relating to chronic growth activation of keratinocytes. Am J Dermatopathol 1991: 13: 438-44.