Unraveling the mystery of adrenal failure in the critically ill

Critical Care Medicine

Volumn 32, Issue 2, 2004, Pages 596-597

  Marik, Paul E ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Adrenal failure; Cortisol; Critical illness; Intensive care unit; Sepsis; Traumatic brain injury

Indexed keywords

BIOCHEMICAL MARKER; CORTICOTROPIN; GLUCOCORTICOID; HYDROCORTISONE; TETRACOSACTIDE;

ADRENAL INSUFFICIENCY; CRITICAL ILLNESS; DIAGNOSTIC TEST; DISEASE MARKER; EDITORIAL; HEMORRHAGIC SHOCK; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNE RESPONSE; LABORATORY TEST; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SEPTIC SHOCK;

ADRENAL GLANDS; CRITICAL ILLNESS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM;

EID: 1242275086     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000110729.73061.4B     Document Type: Editorial

References (18)

1. Marik PE, Zaloga GP: Adrenal insufficiency during septic shock. Crit Care Med 2003; 31:141-145
2. Marik PE, Kiminyo K, Zaloga GP: Adrenal insufficiency in critically ill HIV infected patients. Crit Care Med 2002; 30:1267-1273
3. Harry R, Auzinger G, Wendon J: The clinical importance of adrenal insufficiency in acute hepatic dysfunction. Hepatology 2002; 36: 395-402
4. Dimopoulou I, Tsagarakis S, Anthi A, et al: High prevalence of decreased cortisol reserve in brain-dead potential organ donors. Crit Care Med 2003; 31:1113-1117
5. Kilger E, Weis F, Briegel J, et al: Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med 2003; 31:1068-1074
6. Marik PE, Zaloga GP: Adrenal insufficiency in the critically ill: A new look at an old problem. Chest 2002: 122:1784-1796
7. Dimopoulou I, Tsagarakis S, Kouyialia AT, et al: Hypothalamic-pituitary- adrenal axis dysfunction in critically ill patients with traumatic brain injury: Incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels. Crit Care Med 2004; 32:404-408
8. Hinshaw LB, Beller BK, Chang AC, et al: Corticosteroid/antibiotic treatment of adrenalectomized dogs challenged with lethal E. coli. Circ Shock 1985; 16:265-277
9. Darlington DN, Chew G, Ha T, et al: Corticosterone, but not glucose, treatment enables fasted adrenalectomized rats to survive moderate hemorrhage. Endocrinology 1990; 127:766-772
10. Keh D, Boehnke T, Weber-Cartens S, et al: Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: A double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167:512-520
11. Annane D, Sebille V, Charpentier C, et al: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-871
12. Beishuizen A, Thijs LG, Vermes I: Patterns of corticosteroid-binding globulin and free cortisol index during septic shock and multitrauma. Intensive Care Med 2001; 27: 1584-1591
13. Sun X, Fischer DR, Pritts TA, et al: Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am J Physiol Regulatory Integrative Comp Physiol 2002; 282:R509-R518
14. Liu DH, Su YP, Zhang W, et al: Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats. Crit Care Med 2002; 30:623-627
15. Ali M, Allen HR, Vedeckis WV, et al: Depletion of rat liver glucocorticoid receptor hormone-binding and its mRNA in sepsis. Life Sci 1991; 48:603-611
16. Cooper MD, Stewart PM: Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003; 348:727-734
17. Schenarts CL, Burton JH, Riker RR: Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med 2001; 8:1-7
18. van Leeuwen HJ, van der Bruggen T, van Asbeck BS, et al: Effect of corticosteroids on nuclear factor-kappaB activation and hemodynamics in late septic shock. Crit Care Med 2001; 29:1074-1077