Inactivation of the 3′-5′ Exonuclease of the Replicative T4 DNA Polymerase Allows Translesion DNA Synthesis at an Abasic Site

Journal of Molecular Biology

Volumn 336, Issue 5, 2004, Pages 1023-1034

  Tanguy Le Gac, Nicolas ^a   Delagoutte, Emmanuelle ^b   Germain, Matthieu ^a   Villani, Giuseppe ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

Abasic sites; DNA polymerase; Proof reading exonuclease; Translesion replication

Indexed keywords

3',5' EXONUCLEASE; DNA; DNA POLYMERASE; EXONUCLEASE; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE; GENE 43 PROTEIN, ENTEROBACTERIA PHAGE T4; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; DNA DAMAGE; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; DNA TEMPLATE; ENZYME SUBSTRATE; EXPERIMENT; INHIBITION KINETICS; MEASUREMENT; MUTANT; PRIORITY JOURNAL; PROTEIN BINDING; STIMULATION; STRUCTURE ANALYSIS; WILD TYPE; BACTERIOPHAGE T4; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE;

BACTERIOPHAGE T4; BASE SEQUENCE; DNA DAMAGE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; EXONUCLEASES; KINETICS; MUTATION, MISSENSE; VIRAL PROTEINS;

EID: 1242272083     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.01.005     Document Type: Article

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