Mechanisms underlying the antidopaminergic effect of clonazepam and melatonin in striatum

Neuropharmacology

Volumn 36, Issue 11-12, 1997, Pages 1659-1663

  Tenn, C C ^a   Niles, L P ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

6 hydroxydopamine lesioning; Benzodiazepine receptor; Bicuculline; Cyclic AMP; Dopaminergic supersensitivity; Intrastriatal injection; PK 11195

Indexed keywords

APOMORPHINE; BENZODIAZEPINE RECEPTOR; BICUCULLINE; CLONAZEPAM; CYCLIC AMP; MELATONIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OXIDOPAMINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERSENSITIVITY;

EID: 0031405612     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00165-2     Document Type: Article

References (24)

1. Cole D. G., Kobierski L. A., Konradi C. and Hyman S. E. (1994) 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal nerves. Proceedings of the National Academy of Sciences U.S.A. 91: 9631-9635.
2. Colwell C. S. and Levine M. S. (1995) Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms. Journal of Neuroscience 15: 1704-1713.
3. i and catalytic proteins. Life Sciences 42: 469-475.
4. Gale K. and Casu M. (1981) Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioural implications. Molecular and Cellular Biochemistry 39: 369-405.
5. 2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250: 1429-1432.
6. Golombek D. A., Martinin M. and Cardinali D. P. (1993) Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic system. European Journal of Pharmacology 237: 231-236.
7. Haefely W., Kyburz E., Gerecke M. and Mohler H. (1985) Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationships of their agonists and antagonists. Advances in Drug Research 14: 165-322.
8. Herrera-Marshitz M., Forster C. and Ungerstedt U. (1985) Rotational behaviour elicited by intracerebral injection of apomorphine and pergolide in 6-hydroxydopamine lesioned rats, comparison between systemic and intrastriatal injections. Acta Physiologica Scandinavica 125: 519-527.
9. Kita H. and Kitai S. T. (1988) Glutamate decarboxylase immunoreactive neurons in rat neostriatum: their morphological types and populations. Brain Research 447: 346-352.
10. Mishra R. K., Gardner E. L., Katzman R. and Makman M. H. (1974) Enchancement of dopamine stimulated adenylate cyclase activity in rat caudate after lesions in substantia nigra: evidence for denervation supersensitivity. Proceedings of the National Academy of Sciences U.S.A. 71: 3883-3887.
11. Niles L. P. and Hashemi F. S. (1990) Pharmacological inhibition of forskolin-stimulated adenylate cyclase activity in rat brain by melatonin, its analogs and diazepam. Biochemical Pharmacology 40: 2701-2705.
12. 35S]butylbicyclophosphorothionate binding in rat brain by melatonin. Brain Research Bulletin 24: 635-638.
13. Niles, L. P. (1991) Melatonin interaction with the benzodiazepine-GABA receptor complex in the CNS. In Kynurenine and Serotonin Pathways: Progress in Tryptophan Research, ed. R. Schwarcz, S. N. Young and G. M. Brown, Advances in Experimental Medicine and Biology, Vol. 294, pp. 267-277. Plenum Press, New York.
14. A receptors. FASEB Journal 4: 1469-1480.
15. Paxinos, G. and Watson, C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
16. 2 receptors. Brain Research 519: 255-260.
17. Santiago M. and Westerink B. (1992) The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: dual-probe microdialysis study in awake rats. European Journal of Pharmacology 219: 175-181.
18. Satoh H., Satoh Y. and Honda F. (1976) Adenosine 3′ 5′ cyclic monophosphate as a possible mediator of rotational behaviour induced by dopaminergic receptor stimulation in rats lesioned unilaterally in the substantia nigra. European Journal of Pharmacology 39: 365-377.
19. Scheel-Krüger J. (1983) The GABA receptor and animal behaviour. In GABA Receptors, ed. S. L. Enna, pp. 215-256. Humana Press, New Jersey.
20. Sieghart W. J. (1994) Pharmacology of benzodiazepine receptors: an update. Journal of Psychiatry and Neuroscience 19: 24-29.
21. Sugden D. J. (1983) Psychopharmacological effects of melatonin in mouse and rat. Journal of Pharmacology Experimental Therapeutics 227: 587-591.
22. Tenn C. C. and Niles L. P. (1995) Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism. Journal of Pharmacology and Experimental Therapeutics 274: 84-89.
23. Tenn C. C., Neu J. M. and Niles L. P. (1996) PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum. British Journal of Pharmacology 119: 223-228.
24. Ungerstedt U. (1971) Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiologica Scandinavica 367 (Suppl.): 69-93.