Effect of MPEP, a selective mGluR5 antagonist, on the antielectroshock activity of conventional antiepileptic drugs

Polish Journal of Pharmacology

Volumn 56, Issue 5, 2004, Pages 595-598

  Zadrozniak, Marek ^a   Sekowski, Andrzej ^a   Czuczwar, Stanisław J ^a,b   Borowicz, Kinga K ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Conventional antiepileptic drugs; Maximal electroshock; Metabotropic glutamate receptors; MPEP

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ADD ON THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG SELECTIVITY; ELECTRIC SHOCK; GRAND MAL SEIZURE; MALE; MOUSE; NONHUMAN; SEIZURE THRESHOLD;

ANIMALS; ANTICONVULSANTS; ELECTROSHOCK; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 12344335361     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Barton ME, Peters SC, Shannon HE: Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models. Epilepsy Res, 2003, 56, 17-26.
2. Bordi F, Ugolini A: Group I metabotropic glutamate receptors: implications for brain diseases. Prog Neurobiol, 1999, 59, 55-79.
3. Borowicz KK, Piskorska B, Łuszczki J, Czuczwar SJ: Influence of SIB 1893, a selective mGluR5 receptor antagonist, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. Pol J Pharmacol, 2003, 55, 735-740.
4. Borowicz KK, Stasiuk G, Teter J, Kleinrok Z, Gasior M, Czuczwar SJ: Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice. J Neural Transm 2000, 107, 733-743.
5. Bruno V, Copani A, Bonanno L, Knöpfel T, Kuhn R, Roberts PJ, Nicoletti F: Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur J Pharmacol, 1996, 310, 61-66.
6. Chapman AG, Nanan K, Williams M, Meldrum BS: Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology, 2000, 39, 1567-1574.
7. Kłodzińska A, Bijak M, Chojnacka-Wójcik E, Kroczka B, Świader M, Czuczwar SJ, Pilc A: Roles of group II metabotropic glutamate receptors in modulation of seizure activity. Naunyn Schmiedebergs Arch Pharmacol, 2000, 361, 283-288.
8. Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther, 1949, 96, 99-113.
9. Łuszczki J, Borowicz KK, Czuczwar SJ: SIB 1893 possesses pro- and anticonvulsant activity in the electroshock seizure threshold test in mice. Pol J Pharmacol, 2002, 54, 517-520.
10. Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D, Yamaguchi S et al.: Glutamate receptors: brain function and signal transduction. Brain Res Brain Res Rev, 1998, 26, 230-235.
11. O'Leary DM, Movsesyan V, Vicini S, Faden AI: Selective mGluR5 antagonists MPEP and SIB 1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol, 2000, 131, 1429-1437.
12. Pin JP, Duvoisin R: The metabotropic glutamate receptors: structure and functions. Neuropharmacology, 1995, 34, 1-26.
13. A signaling. Neuropsychopharmacology, 2004, 29, 514-521.