Gender issues

Neurologic Clinics

Volumn 23, Issue 1, 2005, Pages 39-60

  Coyle, Patricia K ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMANTADINE; BETA INTERFERON; BETA1A INTERFERON; BOTULINUM TOXIN; CARBAMAZEPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; ESTRADIOL; ESTRIOL; GESTAGEN; GLATIRAMER; GLUCOCORTICOID; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 4; METHYLPREDNISOLONE; MITOXANTRONE; ORAL CONTRACEPTIVE AGENT; OXYBUTYNIN; PHENYTOIN; PROGESTERONE; PROSTAGLANDIN E1; SEX HORMONE; SILDENAFIL; SPASMOLYTIC AGENT; TESTOSTERONE; TRICYCLIC ANTIDEPRESSANT AGENT; VASOPRESSIN DERIVATIVE;

ACNE; AMENORRHEA; AUTOIMMUNITY; AZOOSPERMIA; BIOLOGY; BLADDER DYSFUNCTION; BONE DISEASE; BREAST FEEDING; CATARACT; CELL ACTIVITY; CLINICAL TRIAL; CONTRACEPTION; CYTOKINE PRODUCTION; DEMOGRAPHY; DISEASE ACTIVITY; DISEASE COURSE; DRUG SAFETY; ENDOCRINE FUNCTION; FETUS DISEASE; FLU LIKE SYNDROME; GENDER; GENETIC POLYMORPHISM; GENETICS; HAIR DISEASE; HEALTH PROGRAM; HEALTH SURVEY; HORMONAL THERAPY; HORMONE ACTION; HORMONE SUBSTITUTION; HORMONE SYNTHESIS; HUMAN; IMMUNE SYSTEM; INFERTILITY; LIPID STORAGE; LIPOATROPHY; LIVEDO RETICULARIS; MENSTRUAL CYCLE; MENSTRUATION DISORDER; MULTIPLE SCLEROSIS; NEUROIMAGING; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; REMISSION; REVIEW; SEX DIFFERENCE; SEXUAL DYSFUNCTION; SIDE EFFECT; SOCIAL PSYCHOLOGY; SPONTANEOUS ABORTION; STRIA; T LYMPHOCYTE ACTIVATION; VACCINATION;

ANIMALS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MULTIPLE SCLEROSIS; SEX CHARACTERISTICS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 12344330435     PISSN: 07338619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ncl.2004.10.003     Document Type: Review

References (99)

1. M.J. Legato Women's health: not for women only Int J Fertil 43 2 1998 65 72
2. G.J. De Vries, and P.A. Boyle Double duty for sex differences in the brain Behav Brain Res 92 1998 205 213
3. V.K. Patchev, and O.F.X. Almeida Gender specificity in the neural regulation of the response to stress Mol Neurobiol 16 1998 63 77
4. 1 histograms Proc Int Soc Mag Reson Med 11 2003 1087
5. W. Rashid, G.R. Davies, and D.T. Chard Gender and intracranial volume effects appear to influence upper cervical cord size more than disease effects in early relapsing-remitting [abstract] Mult Scler 10 2004 S225 S226 Poster 523
6. J.A.P. Da Silva Sex hormones and glucocorticoids: interactions with the immune system Ann N Y Acad Sci 876 1999 102 118
7. J. Kurtz, A. Wiesner, and P. Gotz Gender differences and individual variation in the immune system of the scorpionfly Panorpa vulgaris (Insecta: Mecoptera) Dev Comp Immunol 24 2000 1 12
8. C.C. Whitacre Sex differences in autoimmune disease Nat Immunol 2 2001 777 780
9. J.M. Greer, P.A. Csurhes, and M.P. Pender Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls J Autoimmun 22 2004 345 352
10. K.M. Palaszynski, H. Liu, and K.K. Loo Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis J Neuroimmunol 149 2004 84 89
11. W. Gilmore, L.P. Weiner, and J. Correale Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects J Immunol 158 1997 446 451
12. K.M. Adams, and J.L. Nelson Microchimerism. An investigative frontier in autoimmunity and transplantation JAMA 291 2004 1127 1131
13. P.D. Drew, J.A. Chavis, and R. Bhatt Sex steroid regulation of microglial cell activation. Relevance to multiple sclerosis Ann N Y Acad Sci 1007 2003 329 334
14. J.U. Adams Scratching the surface for estrogen's effects Scientist 2004 28 30
15. I.C. Chikanza Prolactin and neuroimmunomodulation: iIn vitro and in vivo observations Ann N Y Acad Sci 876 1999 119 130
16. R.W. McMurray Bromocriptine in rheumatic and autoimmune diseases Semin Arthritis Rheum 31 2001 21 32
17. M. Mellai, M. Giordano, and S. D'Alfonso Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus Hum Immunol 64 2003 274 284
18. J. Alley, S. Khasabov, and D. Simone More severe neurologic deficits in SJL/J male than female mice following Theiler's virus-induced CNS demyelination Exp Neurol 180 2003 14 24
19. K.E. Hill, M. Pigmans, and R.S. Fujinami Gender variations in early Theiler's virus induced demyelinating disease: differential susceptibility and effects of IL-4, IL-10 and combined IL-4 with IL-10 J Neuroimmunol 85 1998 44 51
20. P.D. Fillmore, E.P. Blankenhorn, and J.F. Zachary Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis Am J Pathol 164 2004 167 175
21. S. Kim, S.M. Liva, and M.A. Dalal Estriol ameliorates autoimmune demyelinating disease Neurology 52 1999 1230 1238
22. K.M. Palaszynski, K.K. Loo, and K.F. Asjpiro Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis J Neuroimmunol 146 2004 144 152
23. M.J. Polanczyk, B.D. Carson, and S. Subramanian Cutting edge: estrogen drives expansion of the CD4+ CD25+ regulatory T cell compartment J Immunol 173 2004 2227 2230
24. R.R. Voskuhl, and K. Palaszynski Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis Neuroscientist 7 2001 258 270
25. R.R. Voskuhl, H. Pitchekian-Halabi, and A. MacKenzie-Graham Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis Ann Neurol 39 1996 724 733
26. M. Ding, J.L. Wong, and N.E. Rogers Gender differences of inducible oxide production in JSJ/J mice with experimental autoimmune encephalomyelitis J Neuroimmunol 77 1997 99 106
27. G. Matarese, V. Sanna, and A. Di Giacomo Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males Eur J Immunol 31 2001 1324 1332
28. V. Sanna, A. Di Giacomo, and A. La Cava Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses J Clin Invest 111 2003 241 250
29. C.J. Willer, D.A. Dyment, and N.J. Risch Twin concordance and sibling recurrence rates in multiple sclerosis Proc Natl Acad Sci USA 100 2003 12877 12882
30. L.T. Nguyen, M. Ramanathan, and B. Weinstock-Guttman Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients J Neurol Sci 209 2003 93 99
31. C. Pelfrey, A. Cotleur, and J. Lee Sex differences in cytokine responses to myelin peptides in multiple sclerosis J Neuroimmunol 130 2002 211
32. T. Wei, and S.L. Lightman The neuroendocrine axis in patients with multiple sclerosis Brain 120 1997 1067 1076
33. S.C. Foster, C. Daniels, and D.N. Bourdette Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis J Neuroimmunol 140 2003 78 87
34. C. Confavreux, S. Vukisic, and P. Adeleine Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process Brain 126 2003 770 782
35. A. Caruso, V.D.G. Gerevini, and M. Castiglione Testosterone amplifies excitotoxic damage of cultured oligodendrocytes J Neurochem 88 2004 1179 1185
36. E.G. Celius, H.F. Harbo, and T. Egeland Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis J Neurol Sci 178 2000 132 135
37. P. Duquette, J. Pleines, and M. Girard The increased susceptibility of women to multiple sclerosis Can J Neurol Sci 19 1992 466 471
38. S. Kikuchi, T. Fukazawa, and M. Niino Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation J Neuroimmunol 128 2002 77 81
39. K.M. Mattila, M. Luomala, and T. Lehtimaki Interaction between ESR1 and HLA-DR2 may contribute to the development of MS in women Neurology 56 2001 1246 1247
40. M. Nino, S. Kikuchi, and T. Fukazawa Estrogen receptor gene polymorphism in Japanese patients with multiple sclerosis J Neurol Sci 179 2000 70 75
41. G. Savettieri, R. Cittadella, and P. Valentino Lack of association between estrogen receptor 1 gene polymorphisms and multiple sclerosis in southern Italy in humans Neurosci Lett 327 2002 115 118
42. A. Goris, S. Heggarty, and M.G. Marrosu Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility Genes Immun 3 2002 470 476
43. O.H. Kantarci, D.D. Hebrink, and S.J. Achenbach CD95 polymorphisms are associated with susceptibility to MS women: a population-based study of CD95 and CD95L in MS J Neuroimmunol 146 2004 162 170
44. O.H. Kantarci, D.D. Hebrink, and S.J. Achenbach Association of APOE polymorphisms with disease severity in MS is limited to women Neurology 62 2004 811 814
45. S.J.M. Weatherby, C.L.A. Mann, and M.B. Davies Pilot study of the relationship between gadolinium-enhancing lesions, gender effect and polymorphisms of antioxidant enzymes in multiple sclerosis J Neurol 247 2000 467 470
46. J.F. Bach Mechanisms of disease: the effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med 347 2002 1080 1086
47. D.R. Wynn, L.T. Kurland, and M. Rodriguez A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota Neurology 40 1990 780 786
48. O. Abramsky Pregnancy and multiple sclerosis Ann Neurol 36 1994 S38 S41
49. S. Bernardi, M.G. Grasso, and R. Bertollini The influence of pregnancy on relapses in multiple sclerosis: a cohort study Acta Neurol Scand 84 1991 403 406
50. K. Birk, and R. Rudick Pregnancy and multiple sclerosis Arch Neurol 43 1986 719 726
51. D.M. Damek, and E. Shuster Pregnancy and multiple sclerosis Mayo Clin Proc 72 1997 977 989
52. B. Runmarker, and O. Andersen Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis Brain 118 1995 253 261 285-91
53. A.D. Sadovnick, K. Eisen, and S.A. Hashimoto Pregnancy and multiple sclerosis. A prospective study Arch Neurol 51 1994 1120 1124
54. D.S. Thompson, L.M. Nelson, and A. Burns The effects of pregnancy in multiple sclerosis: a restrospective study Neurology 36 1987 1097 1099
55. I.J. Elenkov, R.L. Wilder, and V.K. Bakalov IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times J Clin Endocrinol Metab 86 2001 4933 4938
56. M. Marzi, A. Vigano, and D. Trabattoni Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy Clin Exp Immunol 106 1996 127 133
57. A. Boster, S. Gebarski, and D. Mikol Does disruption of the blood brain barrier in pre-eclamptic MS patients predispose to increased disease activity? [abstract] Mult Scler 10 2004 S188 Poster 381
58. C. Confavreux, M. Hutchinson, and M.M. Hours Rate of pregnancy-related relapses in multiple sclerosis N Engl J Med 339 1998 285 291
59. S. Vukusic, M. Hutchinson, and M. Hours Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse Brain 127 2004 1353 1360
60. M.A. Van Walderveen, M.W. Tas, and F. Barkhof Magnetic resonance evaluation of disease activity during pregnancy in multiple sclerosis Neurology 44 1994 327 329
61. R. Orvieto, R. Achiron, and Z. Rotstein Pregnancy and multiple sclerosis: a 2-year experience Eur J Obstet Gynecol Reprod Biol 82 1999 191 194
62. O.H. Kantarci, L.F. Barcellos, and J.R. Oxenberg Men with MS transmit the disease more often to their children than women: the carter effect [abstract] Mult Scler 10 2004 S203 Poster 440
63. Coyle PK. Multiple sclerosis. In: Kaplan PW, editor. Neurologic disease in women. New York: Demos Vermande. p. 251-64.
64. A. Achiron, Z. Rotstein, and S. Noy Intravenous immunoglobulin treatment in the prevention of childbirth-associated acute exacerbations in multiple sclerosis: a pilot study J Neurol 243 1996 25 28
65. G.A. Tagaris, M. Tenzoudi, and G. Panagopoulos Intravenous immunoglobulin in childbirth-related exacerbations of multiple sclerosis J Neurol 52 1999 A133 A144
66. J. Haas Presentation of results of the GAMPPT trial: gammaglobulins post pregnancy in multiple sciences for prevention of exacerbations after delivery. Charcot Foundation Satellite Symposium 2004 European Committee for Treatment and Research in Multiple Sclerosis (Ectrims) Vienna (Austria)
67. A. Achiron, I. Kishner, and M. Dolev Effect of intravenous immunoglobulin treatment on pregnancy and postpartum related relapses in multiple sclerosis J Neurol 251 2004 1133 1137
68. C. Confavreux Intravenous immunoglobulins, pregnancy and multiple sclerosis J Neurol 251 2004 1138 1139
69. J. De Seze, M. Chapelotte, and S. Delalande Intravenous corticosteroids in the postpartum period for reduct acute exacerbations in multiple sclerosis Mult Scler 10 2004 596 597
70. L.M. Nelson, G.M. Franklin, and M.C. Jones Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding JAMA 259 1988 3441 3443
71. J. Worthington, R. Jones, and M. Crawford Pregnancy and multiple sclerosis-a 3-year prospective study J Neurol 241 1994 228 233
72. A.M. Case, and R.L. Reid Effects of the menstrual cycle on medical disorders Arch Intern Med 158 1998 1405 1412
73. M.W.A. Angstwurm, R. Gartner, and H.W.L. Ziegler-Heitbrock Cyclic plasma IL-6 levels during normal menstrual cycle Cytokine 9 1997 370 374
74. R. Smith, and J.W.W. Studd A pilot study of the effect upon multiple sclerosis of the menopause, hormone replacement therapy and the menstrual cycle J R Soc Med 85 1992 612 613
75. S. Wilson, P. Donnan, and R. Swingrem A serial observational study on hormonal influences in MS symptoms [abstract] Mult Scler 10 2004 S188 S189 Poster 382
76. A. Zordrager, and J. DeKeyser Menstrually related worsening of symptoms in multiple sclerosis J Neurol Sci 149 1997 95 97
77. A. Zorgdrager, and J. DeKeyser Premenstrual exacerbations of multiple sclerosis J Neurol Neurosurg Psychiatry 65 1998 279 280
78. 1 values in controls and MS subjects: the role of estradiol Proc Intel Soc Mag Reson Med 11 2003 123
79. S. Bansil, H.S. Lee, and S. Jindal Correlation between sex hormones and magnetic resonance images lesions in multiple sclerosis Acta Neurol Scand 99 1999 91 94
80. C. Pozzilli, P. Falaschi, and C. Mainero MRI in multiple sclerosis during the menstrual cycle: relationship with sex hormone patterns Neurology 53 1999 622 624
81. V. Tomassini, E. Giugni, and C. Mainere Relationship between sex hormones and MRI activity in relapsing-remitting multiple sclerosis Neurology 56 2001 A254
82. S. Poser, N.E. Raun, and J. Wikstrom Pregnancy, oral contraceptives and multiple sclerosis Acta Neurol Scand 59 1979 108 118
83. R. Smith, and J.W. Studd A pilot study on the effect upon multiple sclerosis of the menopause, hormone replacement therapy and the menstrual cycle J R Soc Med 85 1992 612 613
84. L. Villard-Mackintosh, and M.P. Vessey Oral contraceptives and reproductive factors in multiple sclerosis incidence Contraception 47 1993 161 168
85. N. Sinaii, S.D. Cleary, and M.L. Ballweg High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis Hum Reprod 17 2002 2715 2724
86. P.K. Coyle, K. Johnson, and L. Pardo Pregnancy outcomes in patients with multiple sclerosis treated with glatiramer acetate (Copaxone) Neurology 60 Suppl 1 2003 A60
87. M. Sandberg-Wollheim Outcome of pregnancy during treatment with interferon-beta-1a (rebif) in patients with multiple sclerosis Neurology 58 2002 A455
88. V. Heras, M. Tintore, and N. Tellez Study on pregnancy and multiple sclerosis therapies [abstract] Mult Scler 10 2004 S188 Poster 380
89. P.K. Coyle, S. Christie, and P. Fodor MS gender issues: clinical practices of women neurologists Mult Scler 10 2004 582 588
90. D.K.B. Li, G.J. Zhao, and D.W. Paty Randomized controlled trial of interferon-beta-1a in secondary progressive MS Neurology 56 2001 1505 1513
91. J.S. Wolinsky, T.X. Houston, and L. Pardo Effect of glatiramer acetate on primary progressive multiple sclerosis: initial analysis of the completed PROMISE Trial Neurology 62 2004 A97
92. N.L. Sicotte, S.M. Liva, and R. Klutch Treatment of multiple sclerosis with the pregnancy hormone estriol Ann Neurol 52 2002 421 428
93. S.S. Soldan, A.I. Retuerto, and N.L. Sicotte Immune modulation in multiple sclerosis patients with the pregnancy hormone estriol J Immunol 171 2003 6267 6274
94. S. Vukusic, M. El-Etr, and C. Cornie POPARTMUS: a European multicenter trial of post-partum progestin and estriol in multiple sclerosis [abstract] Mult Scler 10 2004 S271 Poster 688
95. R. DasGupta, and C.J. Fowler Sexual and urological dysfunction in multiple sclerosis: better understanding and improved therapies Curr Opin Neurol 15 2002 271 278
96. D. Shabas, and H. Weinreb Preventive healthcare in women with multiple sclerosis J Women's Health Gender-Based Medicine 9 2000 389 395
97. A.K. Stuifbergen, and G.J. Roberts Health promotion practices of women with multiple sclerosis Arch Phys Med Rehabil 78 Suppl 5 1997 S3 S9
98. P.D. Drew, and J.A. Chavis Female sex steroids: effects upon microglial cell activation J Neuroimmunol 111 2000 77 85
99. H. Kleinert, T. Wallerath, and C. Euchenhofer Estrogens increase transcription of the human endothelial NO synthase gene analysis of the transcription factors involve Hypertension 31 1998 582 588