Gender variations in early Theiler's virus induced demyelinating disease: Differential susceptibility and effects of IL-4, IL-10 and combined IL-4 with IL-10

Journal of Neuroimmunology

Volumn 85, Issue 1, 1998, Pages 44-51

  Hill, Kenneth E ^a   Pigmans, Marieke ^b   Fujinami, Robert S ^c   Rose, John W ^a,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Hogeschool Alkmaar   (Netherlands)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Gender bias; Interleukin 10 (IL 10); Interleukin 4 (IL 4); Theiler's murine encephalomyelitis virus (TMEV)

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; HOST SUSCEPTIBILITY; IMMUNOTHERAPY; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; DEMYELINATING DISEASES; DISEASE SUSCEPTIBILITY; DRUG COMBINATIONS; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERLEUKIN-10; INTERLEUKIN-4; MALE; MICE; MICE, INBRED STRAINS; PLAQUE ASSAY; POLIOMYELITIS; SEX CHARACTERISTICS; THEILOVIRUS;

EID: 0032078695     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00263-4     Document Type: Article

References (40)

1. Bogdan C., Vodovotz Y., Nathan C. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1991;1549-1555.
2. Clark, B.R., Engvall, E., 1983. Enzyme-linked immunosorbent assay (ELISA): Theoretical and practical aspects. In: Maggia, E.T. (Ed.), Enzyme-Immunoassay, Chap. 8. CRC Press, Boca Raton, Fl, pp. 167-179.
3. Cua D.J., Hinton D.R., Stohlman S.A. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. J. Immunol. 155:1995;4052-4059.
4. Dalal M., Kim S., Voskuhl R.R. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis (EAE) and induces a T helper 2 (Th2) bias in the autoantigen specific T lymphocyte response. J. Immunol. 159(1):1997;3-6.
5. Dal Canto M.C., Lipton H.L. Primary demyelination in Theiler's virus infection. An ultrastructural study. Lab. Invest. 33:1976;626-637.
6. Dal Canto M.C., Melvold R.W., Kim B.S., Miller S.D. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV). A pathological and immunological comparison. Microsc. Res. Tech. 32:1995;215-229.
7. D'Andrea, A., Aste-Amezagra, M., Valiante, N.M., Ma, X., Kubin, M., Trinchieri, G., 1993. Interleukin 10 (IL-10) inhibits human lymphocyte Interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med., pp. 1041-1048.
8. Ding M., Wong J.L., Rogers N.E., Ignarro L.J., Voskuhl R.R. Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis. J. Neuroimmunol. 77:1997;99-106.
9. Downs, W.G., 1982. Mouse encephalomyelitis virus. In: Foster, H.L., Small, J.D., Fox, J.G. (Eds.), The Mouse in Biomedical Research, Vol. II, Chap. 17. Academic Press, pp. 341-352.
10. Fiorentino D.F., Zlotnik A., Viera P., Mosmann T.R. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:1991;3444-3451.
11. Foster K. Th 1/Th 2 cytokine responses and disease association. Immunovations. 7(2):1995;1-8.
12. Green, E.L., 1981. Breeding systems. In: Foster, H.L., Small, J.D., Fox, J.G. (Eds.), The Mouse in Biomedical Research, Vol. I, Chap. 5. Academic Press, pp. 91-106.
13. Grossman C. Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis. J. Steroid Biochem. 34:1989;241-251.
14. Hedrich, H.J., 1981. Genetic monitoring. In: Foster, H.L., Small, J.D., Fox, J.G. (Eds.), The Mouse in Biomedical Research, Vol. I, Chap. 8. Academic Press, pp. 159-177.
15. Howard M., O'Garra A. Biological properties of interleukin 10. Immunol. Today. 13(6):1992;198-200.
16. Iwasaki Y., Akizuki S., Miwa M. Role of monocyte/macrophage lineage cells in HAM/TSP. Ann. NY Acad. Sci. 724:1994;414-416.
17. Jansson L., Olsson T., Holmdahl R. Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice. J. Neuroimmunol. 53:1994;203-207.
18. Kappel C.A., Melvold R.M., Kim B.S. Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis. J. Neuroimmunol. 29:1990;15-19.
19. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
20. Kurtz C.I.B., Sun X., Fujinami R.S. Protection of SJL/J mice from demyelinating disease mediated by Theiler's murine encephalomyelitis virus. Microb. Pathog. 18:1995;11-27.
21. Lipton, H.L., 1994. Theiler's murine encephalomyelitis virus: animal models. In: McKendall, R.R., Stroop, W.G. (Eds.), Handbook of Neurovirology, Chap. 39. Marcell Dekker, pp. 521-528.
22. Lipton, H.L., Miller, S.D., Melvold, R.W., Fujinami, R.S., 1986. Theiler's murine encephalomyelitis virus (TMEV) infection in mice as a model for multiple sclerosis. In: Norkin, A.L., Oldstone, M.B. (Eds.), Concepts in viral pathogenesis II, pp. 248-254.
23. Lynch, S., Rose, J., 1996. Multiple Sclerosis. Disease A Month. Vol. 12, No. 7.
24. Martin R., McFarland H.F. Immunological aspects of experimental allergic encephalomyelitis in multiple sclerosis. Crit. Rev. Clin. Lab. Sci. 32:1995;121-182.
25. Miller S.D., Gerety S.J. Immunologic aspects of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. Semin. Virol. 1:1990;263-272.
26. Perry V.H., Andersson P.B., Gordon S. Macrophages and inflammation in the central nervous system. Trends Neurosci. 16(7):1993;268-273.
27. Peterson J.D., Waltenbaugh C., Miller S.D. IgG subclass responses to Theiler's murine encephalomyelitis virus infection and immunization suggest a dominant role for Th 1 cells in susceptible mouse strains. Immunology. 75:1992;652-658.
28. Piccinni M., Guidizi M., Biagiotti R., Beloni L., Giannarini L., Sampognaro S., Paronchi P., Manetti F., Annuziato F., Livi C., Romagnani S., Maggi E. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes IL-4 production and membrane CD30 expression in established TH 1 cell clones. J. Immunol. 155:1995;128-133.
29. Powrie F., Menon S., Coffman R.L. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23:1993;3043-3049.
30. Racke M.K., Bonomo A., Scott D.E., Cannella B., Levine A., Raine C.S., Sevach E.M., Rocken M. Cytokine-induced deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1994;1961-1966.
31. Rodriguez M., Pavelko K.D., McKinney C.W., Leibowitz J.L. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J. Immunol. 153:1994;3811-3821.
32. Romagnani S. Th 1 and Th 2 subsets of CD4+ T lymphocytes. Sci. Med. Sci. Am. 1:1994;68-77.
33. Rose, J., 1994. Pathogenesis of viral immune-mediated syndromes. In: McKendall, R.R., Stroop, W.G. (Eds.), Handbook of Neurovirology, Chap. 7. Marcell Dekker, pp. 95-102.
34. Rose, J.W., Hill, K.E. et al., 1997. Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination by Theiler' virus infection. J. Neuroimmun., in press.
35. Rossi C.P., Delcroix M., Huitinga I., McAllister A., van Roojen N., Claassen E., Brahic M. Role of macrophages during Theiler's virus infection. J. Virol. 71(4):1997;3336-3340.
36. Rott O., Fleisher B., Cash E. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24:1994;1434-1440.
37. Schuurs A., Verheul H. Effects of gender and sex steroids on the immune response. J. Steroid Biochem. 35:1990;157-172.
38. Tsunoda I., Fujinami R.S. Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus. J. Neuropathol. Exp. Neurol. 55(6):1996;673-686.
39. Voskuhl R.R., Pitchekian-Halabi H., MacKenzie-Graham A., McFarland H.F., Raine C.S. Gender differences in autoimmune demyelination in the mouse: Implication for multiple sclerosis. Ann. Neurol. 39(6):1996;724-733.
40. Whittingham, D.G., Wood, M.J., 1983. Reproductive physiology. In: Foster, H.L., Small, J.D., Fox, J.G. (Eds.), The Mouse in Biomedical Research, Vol. III, Chap. 9. Academic Press, pp. 138-159.