Deciphering the action mechanism of hepcidin;Le mécanisme d'action de l'hepcidine déchiffré

Medecine/Sciences

Volumn 21, Issue 1, 2005, Pages 7-9

  Nicolas, Gaël ^a   Vaulont, Sophie ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; UPSTREAM STIMULATORY FACTOR 1;

DISEASE ASSOCIATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC CODE; HEMOCHROMATOSIS; IRON OVERLOAD; NONHUMAN; NOTE; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 12344321471     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20052117     Document Type: Note

References (8)

1. Beaumont C. Mécanismes moléculaires de l'homéostasie du fer. Med Sci (Paris) 2004; 20: 68-72.
2. Nicolas G, Benounn M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor (USF2) knockout mice. Proc Natl Acad Sci USA 2001; 98: 8780-5.
3. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001; 276: 7811-9.
4. Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2002; 33: 21-2.
5. Nicolas G, Benounn M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002; 99: 4596-601.
6. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science Express 28 octobre 2004.
7. Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002; 110: 1037-44.
8. Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-3.