Repression of Dpp targets in the Drosophila wing by Brinker

Development

Volumn 131, Issue 24, 2004, Pages 6071-6081

  Winter, Stephanie E ^a   Campbell, Gerard ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Brinker; Dpp; Drosophila wing; Imaginal disc; Repression

Indexed keywords

DECAPENTAPLEGIC PROTEIN; DNA BINDING PROTEIN; GENE PRODUCT; PROTEIN BRINKER; PROTEIN OMB; PROTEIN SAL; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTERIOR POSTERIOR AXIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIFFERENTIAL THRESHOLD; DROSOPHILA; FORELIMB; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; IMMUNOHISTOCHEMISTRY; LIMB DEVELOPMENT; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN TARGETING; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SPECIES DIFFERENTIATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BODY PATTERNING; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WING;

EUKARYOTA; HEXAPODA;

EID: 12344319665     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01538     Document Type: Article

References (47)

1. Aronson, B. D., Fisher, A. L., Blechman, K., Candy, M. and Gergen, J. P. (1997). Groucho-dependent and -independent repression activities of Runt domain proteins. Mol. Cell. Biol. 17, 5581-5587.
2. Barolo, S. and Posakony, J. W. (2002). Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev. 16, 1167-1181.
3. Barrio, R. and de Celis, J. F. (2004). Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway. Proc. Natl. Acad. Sci. USA 101, 6021-6026.
4. Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. and Gelbart, W. M. (1991). An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila. Development 111, 657-666.
5. Campbell, G. and Tomlinson, A. (1999). Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker. Cell 96, 553-562.
6. Chen, G. and Courey, A. J. (2000). Groucho/TLE family proteins and transcriptional repression. Gene 249, 1-16.
7. Chinnadurai, G. (2002). CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 9, 213-224.
8. Clyde, D. E., Corado, M. S., Wu, X., Pare, A., Papatsenko, D. and Small, S. (2003). A self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature 426, 849-853.
9. del Alamo Rodriguez, D., Terriente Felix, J. and Diaz-Benjumea, F. J. (2004). The role of the T-box gene optomotor-blind in patterning the Drosophila wing. Dev. Biol. 268, 481-492.
10. Entchev, E. V., Schwabedissen, A. and Gonzalez-Gaitan, M. (2000). Gradient formation of the TGF-beta homolog Dpp. Cell 103, 981-991.
11. Fisher, A. L., Ohsako, S. and Candy, M. (1996). The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16, 2670-2677.
12. Grigliatti, T. (1986). Mutagenesis. In Drosophila: A Practical Approach (ed. D. B. Roberts), pp. 39-58. Oxford: IRL Press.
13. Hasson, P., Muller, B., Basler, K. and Paroush, Z. (2001). Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. EMBO J. 20, 5725-5736.
14. Hewitt, G. F., Strunk, B. S., Margulies, C., Priputin, T., Wang, X. D., Amey, R., Pabst, B. A., Kosman, D., Reinitz, J. and Arnosti, D. N. (1999). Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. Development 126, 1201-1210.
15. Jazwinska, A., Kirov, N., Wieschaus, E., Roth, S. and Rushlow, C. (1999). The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 96, 563-573.
16. Jiang, J., Rushlow, C. A., Zhou, Q., Small, S. and Levine, M. (1992). Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J. 11 3147-3154.
17. Kalderon, D., Roberts, B. L., Richardson, W. D. and Smith, A. E. (1984). A short amino acid sequence able to specify nuclear location. Cell 39, 499-509.
18. Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J. and Carroll, S. B. (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138.
19. Kim, J., Johnson, K., Chen, H. J., Carroll, S. and Laughon, A. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
20. Kirkpatrick, H., Johnson, K. and Laughon, A. (2001). Repression of dpp targets by binding of brinker to mad sites. J. Biol. Chem. 276, 18216-18222.
21. Kobayashi, M., Goldstein, R. E., Fujioka, M., Paroush, Z. and Jaynes, J. B. (2001). Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries. Development 128, 1805-1815.
22. Lammel, U. and Saumweber, H. (2000). X-linked loci of Drosophila melanogaster causing defects in the morphology of the embryonic salivary glands. Dev. Genes Evol. 210, 525-535.
23. Lammel, U., Meadows, L. and Saumweber, H. (2000). Analysis of Drosophila salivary gland, epidermis and CNS development suggests an additional function of brinker in anterior-posterior cell fate specification. Mech. Dev. 92, 179-191.
24. Langeland, J. A., Attai, S. F., Vorwerk, K. and Carroll, S. B. (1994). Positioning adjacent pair-rule stripes in the posterior Drosophila embryo. Development 120, 2945-2955.
25. Lawrence, P. A. and Johnston, P. (1986). Methods of marking cells. In Drosophila: A Practical Approach (ed. D. B. Roberts), pp. 229-242. Oxford: IRL Press.
26. Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H. and Cohen, S. M. (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.
27. Licht, J. D., Grossel, M. J., Figge, J. and Hansen, U. M. (1990). Drosophila Kruppel protein is a transcriptional repressor. Nature 346, 76-79.
28. Marty, T., Muller, B., Basler, K. and Affolter, M. (2000). Schnurri mediates Dpp-dependent repression of brinker transcription. Nat. Cell Biol. 2, 745-749.
29. Masucci, J. D., Miltenberger, R. J. and Hoffmann, F. M. (1990). Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3′ cis-regulatory elements. Genes Dev. 4, 2011-2023.
30. Minami, M., Kinoshita, N., Kamoshida, Y., Tanimoto, H. and Tabata, T. (1999). brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes. Nature 398, 242-246.
31. Muller, B., Hartmann, B., Pyrowolakis, G., Affolter, M. and Basler, K. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113, 221-233.
32. Nellen, D., Burke, R., Struhl, G. and Basler, K. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.
33. Nibu, Y., Zhang, H. and Levine, M. (2001). Local action of long-range repressors in the Drosophila embryo. EMBO J. 20 2246-2253.
34. Nibu, Y., Senger, K. and Levine, M. (2003). CtBP-independent repression in the Drosophila embryo. Mol. Cell. Biol. 23, 3990-3999.
35. Phippen, T. M., Sweigart, A. L., Moniwa, M., Krumm, A., Davie, J. R. and Parkhurst, S. M. (2000). Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J. Biol. Chem. 275, 37628-37637.
36. Ptashne, M. and Gann, A. (2001). Genes and Signals Cold Spring Harbor, NY. Cold Spring Harbor Laboratory Press.
37. Rivera-Pomar, R. and Jackie, H. (1996). From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet. 12, 478-483.
38. Rushlow, C., Colosimo, P. F., Lin, M. C., Xu, M. and Kirov, N. (2001). Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs. Genes Dev. 15, 340-351.
39. Saller, E. and Bienz, M. (2001). Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription. EMBO Rep. 2, 298-305.
40. Sailer, E., Kelley, A. and Bienz, M. (2002). The transcriptional repressor Brinker antagonizes Wingless signaling. Genes Dev. 16, 1828-1838.
41. Sivasankaran, R., Vigano, M. A., Muller, B., Affolter, M. and Basler, K. (2000). Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker. EMBO J. 19, 6162-6172.
42. Stathopoulos, A. and Levine, M. (2002). Dorsal gradient networks in the Drosophila embryo. Dev. Biol. 246, 57-67.
43. Struffi, P., Corado, M., Kulkarni, M. and Arnosti, D. N. (2004). Quantitative contributions of CtBP-dependent and -independent repression activities of Knirps. Development 131, 2419-2429.
44. Teleman, A. A. and Cohen, S. M. (2000). Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103, 971-980.
45. Thuringer, F., Cohen, S. M. and Bienz, M. (1993). Dissection of an indirect autoregulatory response of a homeotic Drosophila gene. EMBO J. 12, 2419-2430.
46. Zhang, H. and Levine, M. (1999). Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 96, 535-540.
47. Zhang, H., Levine, M. and Ashe, H. L. (2001). Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo. Genes Dev. 15, 261-266.