Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-α, interleukin-1β, interleukin-6, or inducible nitric oxide synthase

Toxicological Sciences

Volumn 83, Issue 1, 2005, Pages 197-203

  Li, Ning ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

IL 1; IL 6; iNOS; LPS; Oatp4; TNF

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; ORGANIC ANION TRANSPORTER; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSFECTION; HEPATOMA CELL; HOMOZYGOSITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RECEPTOR DOWN REGULATION; RNA EXTRACTION; RNA ISOLATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HOMOZYGOTE; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 12344319175     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi003     Document Type: Article

References (40)

1. Andus, T., Bauer, J., and Gerok, W. (1991). Effects of cytokines on the liver. Hepatology 13, 364-375.
2. Argiles, J. M., and Lopez-Soriano, F. J. (1990). The effects of tumour necrosis factor-alpha (cachectin) and tumour growth on hepatic amino acid utilization in the rat. Biochem. J. 266, 123-126.
3. Beutler, B., and Cerami, A. (1988). Tumor necrosis, cachexia, shock, and inflammation: A common mediator. Annu. Rev. Biochem. 57, 505-518.
4. Beutler, B., Milsark, I. W., and Cerami, A. C. (1985). Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869-871.
5. Bolder, U., Ton-Nu, H. T., Schteingart, C. D., Frick, E., and Hofmann, A. F. (1997). Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion. Gastroenterology 112, 214-225.
6. Cerami, A., and Beutler, B. (1988). The role of cachectin/TNF in endotoxic shock and cachexia. Immunol. Today 9, 28-31.
7. Chen, Q., Seol, D. W., Carr, B., and Zarnegar, R. (1997). Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. Hepatology 26, 59-66.
8. Chen, Y. L., Florentin, I., Batt, A. M., Ferrari, L., Giroud, J. P., and Chauvelot-Moachon, L. (1992). Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat. Biochem. Pharmacol. 44, 137-148.
9. Colotta, F., Dower, S. K., Sims, J. E., and Mantovani, A. (1994). The type II 'decoy' receptor: A novel regulatory pathway for interleukin 1. Immunol. Today 15, 562-566.
10. Descombes, P., and Schibler, U. (1991). A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67, 569-579.
11. Glaccum, M. B., Stocking, K. L., Charrier, K., Smith, J. L., Willis, C. R., Maliszewski, C., Livingston, D. J., Peschon, J. J., and Morrissey, P. J. (1997). Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J. Immunol. 159, 3364-3371.
12. Green, R. M., Beier, D., and Gollan, J. L. (1996). Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111, 193-198.
13. Hartley, D. P., and Klaassen, C. D. (2000). Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. Drug Metab. Dispos. 28, 608-616.
14. Hartmann, G., Cheung, A. K., and Piquette-Miller, M. (2002). Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J. Pharmacol. Exp. Ther. 303, 273-281.
15. Hartmann, G., Kim, H., and Piquette-Miller, M. (2001). Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int. Immunopharmacol. 1, 189-199.
16. Heinrich, P. C., Castell, J. V., and Andus, T. (1990). Interleukin-6 and the acute phase response. Biochem. J. 265, 621-636.
17. Kakyo, M., Unno, M., Tokui, T., Nakagomi, R., Nishio, T., Iwasashi, H., Nakai, D., Seki, M., Suzuki, M., Naitoh, T., et al. (1999). Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1. Gastroenterology 117, 770-775.
18. Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., and Kohler, G. (1994). Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339-342.
19. Kubitz, R., Wettstein, M., Warskulat, U., and Haussinger, D. (1999). Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 116, 401-410.
20. Laubach, V. E., Shesely, E. G., Smithies, O., and Sherman, P. A. (1995). Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. U.S.A. 92, 10688-10692.
21. Lewis, M., Tartaglia, L. A., Lee, A., Bennett, G. L., Rice, G. C., Wong, G. H., Chen, E. Y., and Goeddel, D. V. (1991). Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. U.S.A. 88, 2830-2834.
22. Li, N., Choudhuri, S., Cherrington, N. J., and Klaassen, C. D. (2002a). Down-regulation of organic anion transporter 4 (Oatp4) by lipopolysaccharide through toll-like receptor 4. Toxicol. Sci. 66(Suppl.), 1440 (Abstract).
23. Li, N., Hartley, D. P., Cherrington, N. J., and Klaassen, C. D. (2002b). Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J. Pharmacol. Exp. Ther. 301, 551-560.
24. Moseley, R. H., Wang, W., Takeda, H., Lown, K., Shick, L., Ananthanarayanan, M., and Suchy, F. J. (1996). Effect of endotoxin on bile acid transport in rat liver: A potential model for sepsis-associated cholestasis. Am. J. Physiol. 271, G137-G146.
25. Moshage, H. (1997). Cytokines and the hepatic acute phase response. J. Pathol. 181, 257-266.
26. Muriel, P. (2000). Regulation of nitric oxide synthesis in the liver. J. Appl. Toxicol. 20, 189-195.
27. Nadin, L., Butler, A. M., Farrell, G. C., and Murray, M. (1995). Pretranslational down-regulation of cytochromes P4502C11 and 3A2 in male rat liver by tumor necrosis factor alpha. Gastroenterology 109, 198-205.
28. Pascussi, J. M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000). Interleukin-6 negatively regulates the expression of pregnane × receptor and constitutively activated receptor in primary human hepatocytes. Biochem. Biophys. Res. Commun. 274, 707-713.
29. Pfeffer, K., Matsuyama, T., Kundig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Kronke, M., and Mak, T. W. (1993). Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock yet succumb to L. monocytogenes infection. Cell 73, 457-467.
30. Pous, C., Giroud, J. P., Damais, C., Raichvarg, D., and Chauvelot-Moachon, L. (1990). Effect of recombinant human interleukin-1 beta and tumor necrosis factor alpha on liver cytochrome P-450 and serum alpha-1-acid glycoprotein concentrations in the rat. Drug Metab. Dispos. 18, 467-470.
31. Roelofsen, H., Muller, M., and Jansen, P. L. (1997). Regulation of organic anion transport in the liver. Yale J. Biol. Med. 70, 435-445.
32. Roelofsen, H., Schoemaker, B., Bakker, C., Ottenhoff, R., Jansen, P. L., and Elferink, R. P. (1995). Impaired hepatocanalicular organic anion transport in endotoxemic rats. Am. J. Physiol. 269, G427-G434.
33. Sims, J. E., Gayle, M. A., Slack, J. L., Alderson, M. R., Bird, T. A., Giri, J. G., Colotta, F., Re, F., Mantovani, A., Shanebeck, K., et al. (1993). Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. U.S.A. 90, 6155-6159.
34. Soler, C., Valdes, R., Garcia-Manteiga, J., Xaus, J., Comalada, M., Casado, F. J., Modolell, M., Nicholson, B., MacLeod, C., Felipe, A., et al. (2001). Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and-independent mechanisms. J. Biol. Chem. 276, 30043-30049.
35. Trauner, M., Arrese, M., Soroka, C. J., Ananthanarayanan, M., Koeppel, T. A., Schlosser, S. F., Suchy, F. J., Keppler, D., and Boyer, J. L. (1997). The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113, 255-264.
36. Trautwein, C., Rakemann, T., Pietrangelo, A., Plumpe, J., Montosi, G., and Manus, M. P. (1996). C/EBP-beta/LAP controls down-regulation of albumin gene transcription during liver regeneration. J. Biol. Chem. 271, 22262-22270.
37. Volpes, R., van den Oord, J. J., De Vos, R., and Desmet, V. J. (1992). Hepatic expression of type A and type B receptors for tumor necrosis factor. J. Hepatol. 14, 361-369.
38. Vos, T. A., Hooiveld, G. J., Koning, H., Childs, S., Meijer, D. K., Moshage, H., Jansen, P. L., and Muller, M. (1998). Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 28, 1637-1644.
39. Warren, G. W., Poloyac, S. M., Gary, D. S., Mattson, M. P., and Blouin, R. A. (1999). Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration. J. Pharmacol. Exp. Ther. 288, 945-950.
40. Whiting, J. F., Green, R. M., Rosenbluth, A. B., and Gollan, J. L. (1995). Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis. Hepatology 22, 1273-1278.