A novel three-component one-pot synthesis of 1H-imidazol-4-yl-pyridines

Organic Letters

Volumn 7, Issue 1, 2005, Pages 39-42

  Illgen, Katrin ^a   Nerdinger, Sven ^a   Behnke, Dirk ^a   Friedrich, Corina ^a  

^a Biovertis AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINE; CYANIDE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 12344263141     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0480269     Document Type: Article

References (22)

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21. 3 as solvent to remove the polar impurities. The resulting semipure product is purified via preparatory HPLC after evaporation of the solvent.
22. 3 solution in methanol and 50 μL of a 0.1 M (n = 5 μmol isocyanide solution in methanol are added. The plate is shaken overnight at room temperature. The solvent is removed under reduced pressure. To analyze plate by fast LC-MS the residue was dissolved in 1:1 methanol/ water to give a 1 mM solution.