Comparative effects of TGF-β1 and TGF-β2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma

Experimental Eye Research

Volumn 80, Issue 1, 2005, Pages 121-134

  Kottler, Ulrike B ^a   Jünemann, Anselm G M ^a   Aigner, Thomas ^a   Zenkel, Matthias ^a   Rummelt, Carmen ^a   Schlötzer Schrehardt, Ursula ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

cell culture; collagen contraction; extracellular matrix; glaucoma filtration surgery; migration; primary open angle glaucoma; proliferation; pseudoexfoliation syndrome; Tenon's capsule fibroblasts; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; ISOPROTEIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AGED; ARTICLE; CATARACT; CELL ASSAY; CELL CULTURE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; COLORIMETRY; COMPARATIVE STUDY; COMPUTER ANALYSIS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FIBER; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NUCLEOTIDE SEQUENCE; OPEN ANGLE GLAUCOMA; PATHOPHYSIOLOGY; PATIENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PSEUDOEXFOLIATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SYNDROME; THREE DIMENSIONAL IMAGING; TIME; TRANSMISSION ELECTRON MICROSCOPY;

AGED; CATARACT; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; CONNECTIVE TISSUE; EXFOLIATION SYNDROME; EXTRACELLULAR MATRIX; EYE; FEMALE; FIBROBLASTS; GLAUCOMA, OPEN-ANGLE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROSCOPY, ELECTRON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 12344258809     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2004.08.018     Document Type: Article

References (59)

1. R.A. Alexander, and A. Garner Oxytalan fibre formation in the cornea: a light and electron microscopical study Histopathology 1 1977 189 199
2. W.A. Border, and N.A. Noble Transforming growth factor β in tissue fibrosis New Engl. J. Med. 331 1994 1286 1292
3. M.R. Chang, Q. Cheng, and D.A. Lee Basic Science and clinical aspects of wound healing in glaucoma filtering surgery J. Ocular Pharmacol. Ther. 14 1998 75 95
4. C. Chen, B. Michelini-Norris, S. Stevens, J. Rowsey, X. Ren, M. Goldstein, and G. Schultz Measurement of mRNAs for TGFss and extracellular matrix proteins in corneas of rats after PRK Invest. Ophthalmol. Vis. Sci. 41 2000 4108 4116
5. B.S. Christiansen, J. Ingerslev, L. Heickendorff, and C.M. Petersen Human hepatocytes in culture synthesize and secrete fibronectin Scand. J. Clin. Lab. Invest. 48 1988 685 690
6. M.F. Cordeiro Beyond mitomycin: TGF-β and wound healing Progr. Ret. Eye Res. 21 2002 75 89
7. M.F. Cordeiro, J.A. Gay, and P.T. Khaw Human anti-transforming growth factor-β2 antibody: a new glaucoma anti-scarring agent Invest. Ophthalmol. Vis. Sci. 40 1999 2225 2234
8. M.F. Cordeiro, M.B. Reichel, J.A. Gay, F. D'Esposita, R.A. Alexander, and P.T. Khaw Transforming growth factor-β1, -β2, and -β3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring Invest. Ophthalmol. Vis. Sci. 40 1999 1975 1982
9. M.F. Cordeiro, S.S. Bhattacharya, G.S. Schultz, and P.T. Khaw TGF-β1, -β2, and -β3 in vitro: BIPHASIC effects on Tenon's fibroblast contraction, proliferation, and migration Invest. Ophthalmol. Vis. Sci. 41 2000 756 763
10. M.F. Cordeiro, L. Chang, K. Sheng Lim, J.T. Daniels, R.D. Pleass, D. Siriwardena, and P.T. Khaw Modulating conjunctival wound healing Eye 14 2000 536 547
11. V.P. Costa, G.L. Spaeth, R.A. Eiferman, and S. Orengo-Nania Wound healing modulation in glaucoma filtration surgery Ophthalm. Surg. 24 1993 152 170
12. I.A. Cunliffe, R.C. Rees, and I.G. Rennie The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon's capsule fibroblasts in tissue culture Acta Ophthalmol. Scand. 74 1996 31 35
13. J.T. Daniels, N.L. Occleston, J.C. Crowston, M.F. Cordeiro, R.A. Alexander, M. Wilkins, R. Porter, R. Brown, and P.T. Khaw Understanding and controlling the scarring response: the contribution of histology and microscopy Microsc. Res. Tech. 42 1998 317 333
14. J.T. Daniels, A.D. Cambrey, N.L. Occleston, Q. Garrett, R.W. Tarnuzzer, G.S. Schultz, and P.T. Khaw Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro Invest. Ophthalmol. Vis. Sci. 44 2003 1104 1110
15. P.O. Denk, S. Roth-Eichhorn, A.M. Gressner, and M. Knorr Effect of cytokines on regulation of the production of transforming growth factor beta-1 in cultured human Tenon's capsule fibroblasts Eur. J. Ophthalmol. 10 2000 110 115
16. P.O. Denk, S. Roth-Eichhorn, A.M. Gressner, and M. Knorr Cytokine regulation of hyaluronate production by human Tenon's capsule fibroblasts Curr. Eye Res. 20 2000 77 80
17. P.O. Denk, J. Hoppe, V. Hoppe, and M. Knorr Effect of growth factors on the activation of human Tenon's capsule fibroblasts Curr. Eye Res. 27 2003 35 44
18. M.J. Elder, J.K.G. Dart, and S. Lightman Conjunctival fibrosis in ocular cicatricial pemphigoid-the role of cytokines Exp. Eye Res. 65 1997 165 176
19. E. Engvall Enzyme immunoassay ELISA and EMIT Methods Enzymol. 70 1980 419 439
20. S. Frank, M. Madlener, and S. Werner Transforming growth factors β1, β2, and β3 and their receptors are differentially regulated during normal and impaired wound healing J. Biol. Chem. 271 1996 10188 10193
21. A. Gehrsitz, L.A. McKenna, S. Soeder, T. Kirchner, and T. Aigner Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects J. Orthop. Res. 19 2001 478 482
22. A. Ghahary, Y.J. Shen, P.G. Scott, and E.E. Tredget Immunolocalization of TGF-β1 in human hypertrophic and normal dermal tissue Cytokine 7 1995 184 190
23. R.L. Gross Collagen type I and III synthesis by Tenon's capsule fibroblasts in culture: individual patient characterstics and response to mitomycin C, 5-fluorouracil, and ascorbic acid Trans. Am. Ophthalmol. Soc. 97 1999 513 543
24. M. Gruschwitz, P.U. Muller, N. Sepp, E. Hofer, A. Fontana, and G. Wick Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: a mediator of fibrosis? J. Invest. Dermatol. 94 1990 197 203
25. A. Gupta, D. Monroy, Z. Ji, K. Yoshino, A. Huang, and S.C. Pflugfelder Transforming growth factor beta-1 and beta-2 in human tear fluid Curr. Eye Res. 15 1996 605 614
26. R.A. Hitchings, and I. Grierson Clinico-pathological correlation in eyes with failed fistulizing surgery Trans. Ophthalmol. Soc. UK 103 1983 84 88
27. M. Huygens, K. Vercruysse, M. Goethals, and L. Missotten Trabeculectomy: a retrospective long-term follow-up study Bull. Soc. Belge Ophthalmol. 238 1990 125 135
28. E.P. Kay, H.K. Lee, K.S. Park, and S.C. Lee Indirect mitogenic effect of transforming growth factor-β on cell proliferation of subconjunctival fibroblasts Invest. Ophthalmol. Vis. Sci. 39 1998 481 486
29. P.T. Khaw, N.L. Occleston, G. Schultz, I. Grierson, M.B. Sherwood, and G. Larkin Activation and suppression of fibroblast function Eye 8 1994 188 195
30. P.T. Khaw, L. Chang, T.T.L. Wong, A. Mead, J.T. Daniels, and M.F. Cordeiro Modulation of wound healing after glaucoma surgery Curr. Opin. Ophthalmol. 12 2001 143 156
31. G.G. Koliakos, R. Schlötzer-Schrehardt, A.G.P. Konstas, T. Bufidis, N. Georgiadis, and A. Dimitriadou Transforming and insulin-like growth factors in the aqueous humour of patients with exfoliation syndrome Graefe's Arch. Clin. Exp. Ophthalmol. 239 2001 482 487
32. T.L. Koller, J. Stürmer, and B. Gloor Risikofaktoren für das Versagen einer Trabekulektomie Klin. Monatsbl. Augenheilkd. 213 1998 1 8
33. U.B. Kottler, U. Schlötzer-Schrehardt, S. Berthold, C. Kramann, F. Grus, and N. Pfeiffer Elevated levels of TGF-β1 and TGF-β2 in the tear fluid of patients with pseudoexfoliation and primary open-angle glaucoma Ophthalmic. Res. 35 2003 S50 (Abstract)
34. U.B. Kottler, U. Schlötzer-Schrehardt, N. Pfeiffer, G.O.H. Naumann, and A.G.M. Jünemann Expression of TGF-β1 and TGF-β2 in failed filtering blebs of patients with pseudoexfoliation and primary open-angle glaucoma Invest. Ophthalmol. Vis. Sci. 44 2003 S50 (Abstract)
35. J.H. Levine, H.L. Moses, L.I. Gold, and L.B. Nanney Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair Am. J. Pathol. 143 1993 368 380
36. D.Q. Li, S.B. Lee, and S.C. Tseng Differential expression and regulation of TGF-beta1, TGF-beta2, TGF-beta3, TGF-betaRI, TGF-betaRII and TGF-betaRIII in cultured human corneal, limbal, and conjunctival fibroblasts Curr. Eye Res. 19 1999 154 161
37. H. Mietz, P. Chevez-Barrios, M.W. Lieberman, M. Wendt, R. Gross, and S.F. Basinger Decorin and suramin inhibit ocular fibroblast collagen production Graefe's Arch. Clin. Exp. Ophthalmol. 235 1997 399 403
38. H. Mietz, P. Chevez-Barrios, and M.W. Lieberman A mouse model to study the wound healing response following filtration surgery Graefes Arch. Clin. Exp. Ophthalmol. 236 1998 467 475
39. S.E. Mutsaers, J.E. Bishop, G. McGrouther, and G.J. Laurent Mechanisms of tissue repair: from wound healing to fibrosis Int. J. Biochem. Cell Biol. 29 1997 5 17
40. N.X. Nguyen, M. Küchle, P. Martus, and G.O.H. Naumann Quantification of blood-aqueous barrier breakdown after trabeculectomy: pseudoexfoliation versus primary open-angle glaucoma J. Glaucoma 8 1999 18 23
41. N. Occleston, J.T. Daniels, R.W. Tarnuzzer, K.K. Sethi, R.A. Alexander, S.S. Bhattacharya, G.S. Schultz, and P.T. Khaw Single exposures to antiproliferatives Invest. Ophthalmol. Vis. Sci. 38 1997 1998 2007
42. S. O'Kane, and M.W.J. Ferguson Transforming growth factor βs and wound healing Int. J. Biochem. Cell Biol. 29 1997 63 78
43. E. Olivius, and W. Thorburn Prognosis of glaucoma simplex and glaucoma capsulare Acta Ophthalmol. 56 1978 921 934
44. R.A. Pena, J.A. Jerdan, and B.M. Glaser Effects of TGF-β and TGF-β neutralizing antibodies on fibroblast-induced collagen gel contraction: Implications for proliferative vitreoretinopathy Invest. Ophthalmol. Vis. Sci. 35 1994 2804 2808
45. G. Picht, U. Welge-Luessen, F. Grehn, and E. Lütjen-Drecoll Transforming growth factor β2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb formation Graefe's Arch. Clin. Exp. Ophthalmol. 239 2001 199 207
46. R.L. Radius, J. Herschler, A. Claflin, and G. Fiorentino Aqueous humor changes after experimental filtering surgery Am. J. Ophthalmol. 89 1980 250 254
47. A.B. Roberts, M.B. Sporn, R.K. Assoian, J.M. Smith, and N.S. Roche Transforming growth factor beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro Proc. Natl Acad. Sci. USA 83 1986 4167 4171
48. S. Saika, O. Yamanaka, Y. Kawashima, K. Ohkawa, Y. Ohnishi, A. Ooshima, M. Kimura, Y. Nakano, and W.W-Y. Kao OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-β1 in vitro Curr. Eye Res. 17 1998 933 940
49. S. Saika, O. Yamanaka, Y. Baba, Y. Kawashima, K. Shirai, T. Miyamoto, Y. Okada, Y. Ohnishi, and A. Ooshima Accumulation of latent transforming growth factor-β binding protein-1 and TGF-β1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts Graefe's Arch. Clin. Exp. Ophthalmol. 239 2001 234 241
50. U. Schlötzer-Schrehardt, and G.O.H. Naumann Pseudoexfoliation glaucoma F. Grehn R. Stamper Essentials in Ophthalmology: Glaucoma 2004 157 176
51. U. Schlötzer-Schrehardt, M. Zenkel, M. Küchle, L.Y. Sakai, and G.O.H. Naumann Role of transforming growth factor-β1 and ist latent form binding protein in pseudoexfoliation syndrome Exp. Eye Res. 73 2001 765 780
52. P. Schmid, D. Cox, G. Bilbe, G. McMaster, C. Morrison, H. Stahelin, N. Luscher, and W. Seiler TGF-betas and TGF-beta type II receptor in human epidermis: differential expression in acute and chronic skin wounds J. Pathol. 171 1993 191 197
53. M. Shah, D.M. Foreman, and M.W.J. Ferguson Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring J. Cell Sci. 108 1995 985 1002
54. D. Siriwardena, P.T. Khaw, A.J. King, M.L. Donaldson, B.M. Overton, C. Migdal, and M.F. Cordeiro Human antitransforming growth factor β2 monoclonal antibody - a new modulator of wound healing in trabeculectomy Ophthalmology 109 2002 427 431
55. R.C. Tripathi, J. Li, W.F.A. Chan, and B.J. Tripathi Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2 Exp. Eye Res. 59 1994 723 728
56. R.C. Tripathi, J. Li, K.V. Chalam, and B.J. Tripathi Expression of growth factor mRNAs by human Tenon's capsule fibroblasts Exp. Eye Res. 63 1996 339 346
57. J. Varga, J. Rosenbloom, and S.A. Jimenez Transforming growth factor beta (TGF beta) causes a persistent increase in steady state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts Biochem. J. 247 1987 597 604
58. M.D. Wendt, C.N. Soparkar, K. Louie, S.F. Basinger, and R.L. Gross Ascorbate stimulates type I and type III collagen in human Tenon's fibroblasts J. Glaucoma 6 1997 402 407
59. S. Werner, and R. Grose Regulation of wound healing by growth factors and cytokines Physiol. Rev. 83 2003 835 870