In vitro effects of anaesthetic agents on the blood-brain barrier;In-vitro-effekte von anästhetika auf die blut-hirn-schranke

Anaesthesist

Volumn 53, Issue 12, 2004, Pages 1177-1184

  Fischer, S ^a   Renz, D ^a   Kleinstuck J ^b   Schaper, W ^b   Karliczek, G F ^a  

^a KERCKHOFF HEART CENTER   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Anaesthetics; Blood brain barrier; In vitro model; Permeability; Vascular endothelial growth factor

Indexed keywords

DESFLURANE; ENFLURANE; ETOMIDATE; FENTANYL; HALOTHANE; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; INULIN; ISOFLURANE; KETAMINE; MIDAZOLAM; OXYBATE SODIUM; PROPOFOL; SEVOFLURANE; TRITIUM; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN HYPOXIA; BRAIN MICROCIRCULATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HEMODYNAMICS; INHALATION ANESTHESIA; INTRAVENOUS ANESTHESIA; MICROVASCULATURE; NERVE CELL CULTURE; NONHUMAN; NORTHERN BLOTTING; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

ANESTHETICS; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; ANOXIA; BLOOD-BRAIN BARRIER; BLOTTING, NORTHERN; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 12344252573     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-004-0740-y     Document Type: Article

References (31)

1. Audus KL, Borchardt RT (1986) Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharmacol Res 3:81-87
2. Brightman MW, Tao-Cheng JH (1993) Tight junctions of brain endothelium and epithelium. In: Pardridge WM (eds) The blood-brain barrier. Raven, New York, pp 107-125
3. Bruce JN, Criscuolo GR, Merrill MJ et al. (1987) Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone. J Neurosurg 67:880-884
4. Cahn R, Dupont JM, Borzeix MG (1990) Effect of halothane on ischemic brain edema. Adv Neurol 52:93-96
5. Chi OZ, Anwar M, Sinha AK et al. (1992) Effects of isoflurane on transport across the blood-brain barrier. Anesthesiology 76:426-431
6. Chi OZ, Wei HM, Anwar M et al. (1992) Effects of fentanyl on alpha-aminoisobutyric acid transfer across the blood-brain barrier. Anesth Analg 75:31-36
7. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
8. Connolly DT, Heuvelman DM, Nelson R et al. (1989) Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470-1478
9. Dvorak HF, Brown LF, Detmar M et al. (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029-1039
10. Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851-858
11. Fischer S, Sharma HS, Karliczek GF et al. (1995) Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine. Mol Brain Res 28:141-148
12. Fischer S, Renz D, Schaper W et al. (1995) In vitro effects of fentanyl, methohexital, and thiopental on brain endothelial permeability. Anesthesiology 82:451-458
13. Fischer S, Renz D, Schaper W et al. (1996) Effects of barbiturates on hypoxic cultures of brain-derived microvascular endothelial cells. Brain Res 707:47-53
14. Fischer S, Renz D, Schaper W et al. (1998) Barbiturates decrease the expression of vascular endothelial growth-factor in hypoxic cultures of porcine brain-derived microvascular endothelial cells. Mol Brain Res 60:89-97
15. Fischer S, Clauss M, Wiesnet M et al. (1999) Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. Am J Physiol 276:C812-820
16. Fischer S, Renz D, Wiesnet M et al. (1999) Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells. Mol Brain Res 74:135-144
17. Fischer S, Wobben M, Renz D et al. (2000) Hypoxia-induced permeability and expression of vascular endothelial growth factor in brain microvessel endothelial cells is decreased by astroglial cells. Eur J Cell Biol Suppl 50:97
18. Gelman S, Fowler K, Smith L (1984) Regional blood flow during isoflurane and halothane anesthesia. Anesth Analg 63:557-565
19. Hatashita S, Hoff JT (1990) Brain edema and cerebrovascular permeability during cerebral ischemia in rats. Stroke 21:582-588
20. Kahraman S, Demiryurek AT (1997) Propofol is a peroxynitrite scavenger. Anesth Analg 84:1127-1129
21. Kuroiwa T, Cahn R, Juhler M (1985) Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol 66:3-11
22. Michenfelder JD, Theye RA (1973) Cerebral protection by thiopental during hypoxia. Anesthesiology 39:510-517
23. Michenfelder JD, Milde JH, Sundt TM (1976) Cerebral protection by barbiturate anesthesia: use after middle cerebral artery occlusion in Java monkeys. Arch Neurol 33:345-350
24. Milton S, Knutson V (1990) Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer. J Cell Physiol 144:498-504
25. Mischek U, Meyer J, Galla H-J (1989) Characterization of γ-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillaries. Cell Tissue Res 256:221-226
26. Nemoto EM, Stezoski SW, MacMurdo D (1978) Glucose transport across the blood-brain barrier during anesthesia. Anesthesiology 76:170-176
27. Saija A, Princi P, Pasquale R de et al. (1989) Modifications of the permeability of the blood-brain barrier and local cerebral metabolism in pentobarbital- and ketamine-anaesthetized rats. Neuropharmacology 28:997-1002
28. Senger DR, Ledbetter SR, Claffey KP et al. (1996) Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving αcvβ3 integrin, osteopontin, and thrombin. Am J Pathol 149:293-305
29. Smith AL, Hoff JT, Nielsen SL et al. (1974) Barbiturate protection in acute cerebral ischemia. Stroke 5:1-7
30. Wu HM, Huang QB, Yuan Y et al. (1996) VEGF induces NO-dependent hyperpermeability in coronary venules. Am J Physiol 40:H2735-2739
31. Yamada K, Bremer A, West C (1979) Effects of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys. J Neurosurg 50:361-367