Anthrax edema toxin requires influx of calcium for inducing cyclic AMP toxicity in target cells

Infection and Immunity

Volumn 70, Issue 9, 2002, Pages 4997-5007

  Kumar, Praveen ^a   Ahuja, Nidhi ^a   Bhatnagar, Rakesh ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; CALCIUM ION; CYCLIC AMP; EDEMA TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTHRAX; ANTIGEN BINDING; ARTICLE; BACILLUS ANTHRACIS; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MACROPHAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ADENYLATE CYCLASE; ANIMALS; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL LINE; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; KINETICS; LYMPHOCYTES; MACROPHAGES; NEUTROPHILS;

EID: 0036719095     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.9.4997-5007.2002     Document Type: Article

References (33)

1. Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigen
2. Rapid purification of recombinant anthrax-protective antigen under nondenaturing conditions
3. Calcium is required for expression of anthrax lethal toxin activity in the macrophage-like cell line J774A.1
4. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)
5. Modulation of inflammation and immunity by cyclic AMP
6. Identification of the cellular receptor for anthrax toxin
7. Effects of prostaglandins on the spreading, adhesion and migration of mouse peritoneal macrophages
8. Voltage sensitive calcium channels in normal and transformed 3T3 fibroblasts
9. 8-Chloro-cAMP modulates apoptosis of thymocytes and thymocyte hybridoma
10. Barium influx mediated by the cardiac sodium-calcium exchanger in transfected Chinese hamster ovary cells
11. What's new with calcium?
12. Macrophages are sensitive to anthrax toxin through an acid-dependent process
13. Translocation of Bacillus anthracis lethal and oedema factors across endosomal membranes
14. Regulation of ciliary adenylate cyclase by calcium in paramecium
15. Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP
16. Regulation of the calcium signal by calmodulin
17. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
18. Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen
19. Anthrax toxin edema factor: A bacterial adenylate cyclase that increases cAMP concentration in eukaryotic cells
20. Bacillus anthracis calmodulin-dependent adenylate cyclase: Chemical and enzymatic properties and interaction with eukaryotic cells
21. The anthrax toxin complex
22. Poliferation of human peripheral mononuclear cells during calcium channel blockade
23. pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen
24. Effects of anthrax toxin components on human neutrophils
25. Effects of prostaglandins on phagocytosis of sheep erythrocytes by mouse peritoneal macrophages
26. Calcium channel blockers nifedipine and diltiazem inhibit calcium release from intracellular stores in neutrophils
27. Point mutations in anthrax protective antigen that block translocation
28. Cyclic AMP-dependent protein kinase I mediates the inhibitory effects of 3′,5′ cyclic adenosine monophosphate on cell replication in human T-lymphocytes
29. Observations on experimental anthrax: Demonstration of a specific lethal factor produced in vivo by Bacillus anthracis
30. Purification of factor I and recognition of a third factor of anthrax toxin
31. Role of cAMP in reducing superoxide anion generation in guinea pig alveolar macrophages
32. 2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila and rat