메뉴 건너뛰기




Volumn 28, Issue 6 II, 2002, Pages

Secretion of glycated insulin from pancreatic β-cells in diabetes represents a novel aspect of β-cell dysfunction and glucose toxicity

Author keywords

Defective insulin action; Defective insulin secretion; Diabetes; Glycated insulin; Glycation; Insulin; Pancreatic cell

Indexed keywords

GLUCOSE; INSULIN;

EID: 12244304179     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (20)

References (31)
  • 3
    • 0019471997 scopus 로고
    • Abnormal plasma glucose and insulin responses in heterozygous lean (obl+) mice
    • Flatt PR, Bailey CJ. Abnormal plasma glucose and insulin responses in heterozygous lean (obl+) mice. Diabetologia, 1981, 20, 573-577.
    • (1981) Diabetologia , vol.20 , pp. 573-577
    • Flatt, P.R.1    Bailey, C.J.2
  • 4
    • 0025142898 scopus 로고
    • Natural history of β-cell dysfunction in NIDDM
    • Leahy JL. Natural history of β-cell dysfunction in NIDDM. Diabetes Care, 1990, 13, 992-1010.
    • (1990) Diabetes Care , vol.13 , pp. 992-1010
    • Leahy, J.L.1
  • 6
    • 0021961644 scopus 로고
    • Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications of the management of diabetes
    • Unger RH, Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications of the management of diabetes. Diabetologia, 1985, 28, 119-121.
    • (1985) Diabetologia , vol.28 , pp. 119-121
    • Unger, R.H.1    Grundy, S.2
  • 7
    • 0026088145 scopus 로고
    • Evolution of insulin secretory response to glucose by perfused islets from lean (fa/fa) rats chronically infused with glucose
    • Bedoya FJ, Jeanrenaud B. Evolution of insulin secretory response to glucose by perfused islets from lean (fa/fa) rats chronically infused with glucose. Diabetes, 1991, 40, 7-14.
    • (1991) Diabetes , vol.40 , pp. 7-14
    • Bedoya, F.J.1    Jeanrenaud, B.2
  • 8
    • 0026091234 scopus 로고
    • Monolayer culture of adult rat pancreatic islets on extracellular matrix: Modulation of β-cell function by chronic exposure to high glucose
    • Kaiser N, Corcos AP, Sarel I, Cerasi E. Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of β-cell function by chronic exposure to high glucose. Endocrinology, 1991, 129, 2067-2076.
    • (1991) Endocrinology , vol.129 , pp. 2067-2076
    • Kaiser, N.1    Corcos, A.P.2    Sarel, I.3    Cerasi, E.4
  • 9
    • 0026607455 scopus 로고
    • Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: Evidence supporting specific desensitization rather than β-cell exhaustion
    • Davalli AM, Ricordi C, Socci C, et al. Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: Evidence supporting specific desensitization rather than β-cell exhaustion. J Clin Endocrinol Metabol, 1992, 74, 790-794.
    • (1992) J Clin Endocrinol Metabol , vol.74 , pp. 790-794
    • Davalli, A.M.1    Ricordi, C.2    Socci, C.3
  • 10
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function
    • Eizirik EL, Korbutt GS, Hellerstrom C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest, 1992, 90, 1263-1268.
    • (1992) J Clin Invest , vol.90 , pp. 1263-1268
    • Eizirik, E.L.1    Korbutt, G.S.2    Hellerstrom, C.3
  • 11
    • 0027180813 scopus 로고
    • Lack of long term β-cell glucotoxicity in vitro in pancreatic islets isolated from two mouse strains (C57BL/6J; C57BL/KsJ) with different sensitivities of the β-cells to hyperglycaemia in vivo
    • Svensson C, Sandler S, Hellerstrom C. Lack of long term β-cell glucotoxicity in vitro in pancreatic islets isolated from two mouse strains (C57BL/6J; C57BL/KsJ) with different sensitivities of the β-cells to hyperglycaemia in vivo. J Endocrinol, 1993, 136, 289-296.
    • (1993) J Endocrinol , vol.136 , pp. 289-296
    • Svensson, C.1    Sandler, S.2    Hellerstrom, C.3
  • 12
    • 0029742094 scopus 로고    scopus 로고
    • Characterisation of a novel glucose-responsive insulin-secreting cell line BRIN-BD11, produced by electrofusion
    • McClenaghan NH, Barnett CR, Ah-Sing E, et al. Characterisation of a novel glucose-responsive insulin-secreting cell line BRIN-BD11, produced by electrofusion. Diabetes, 1996, 45, 1132-1140.
    • (1996) Diabetes , vol.45 , pp. 1132-1140
    • McClenaghan, N.H.1    Barnett, C.R.2    Ah-Sing, E.3
  • 15
    • 0034283354 scopus 로고    scopus 로고
    • Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle
    • Boyd AC, Abdel-Wahab YHA, McKillop AM, et al. Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle. Biochim Biophys Acta, 2000, 1523, 128-134.
    • (2000) Biochim Biophys Acta , vol.1523 , pp. 128-134
    • Boyd, A.C.1    Abdel-Wahab, Y.H.A.2    McKillop, A.M.3
  • 16
    • 0033786581 scopus 로고    scopus 로고
    • Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin
    • O'Harte FPM, Boyd AC, McKillop AM, et al. Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin. Peptides, 2000, 21, 1519-1526.
    • (2000) Peptides , vol.21 , pp. 1519-1526
    • O'Harte, F.P.M.1    Boyd, A.C.2    McKillop, A.M.3
  • 17
    • 0023803371 scopus 로고
    • Advanced products of non-enzymatic glycosylation and the pathogenesis of diabetic vascular disease
    • Brownlee M, Cerami A, Vlassara H. Advanced products of non-enzymatic glycosylation and the pathogenesis of diabetic vascular disease. Diabetes Metab Rev, 1988, 4, 437-451.
    • (1988) Diabetes Metab Rev , vol.4 , pp. 437-451
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 18
    • 0029560077 scopus 로고
    • The pathological implications of protein glycation
    • Brownlee M. The pathological implications of protein glycation. Clin Invest Med, 1995, 18, 275-281.
    • (1995) Clin Invest Med , vol.18 , pp. 275-281
    • Brownlee, M.1
  • 19
    • 0031437194 scopus 로고    scopus 로고
    • Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: A carbonyl stress hypothesis
    • Lyons TJ, Jenkins AJ. Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis. Diabetes Reviews, 1997, 5, 365-391.
    • (1997) Diabetes Reviews , vol.5 , pp. 365-391
    • Lyons, T.J.1    Jenkins, A.J.2
  • 20
    • 0031030963 scopus 로고    scopus 로고
    • Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture
    • Abdel-Wahab YHA, O'Harte FPM, Barnett CR, Flatt PR. Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture. J Endocrinol, 1997, 152, 59-67.
    • (1997) J Endocrinol , vol.152 , pp. 59-67
    • Abdel-Wahab, Y.H.A.1    O'Harte, F.P.M.2    Barnett, C.R.3    Flatt, P.R.4
  • 21
    • 0030473543 scopus 로고    scopus 로고
    • Identification of the site of glycation of human insulin
    • O'Harte FPM, Højrup P, Barnett CR, Flatt PR. Identification of the site of glycation of human insulin. Peptides, 1996, 17, 1323-1330.
    • (1996) Peptides , vol.17 , pp. 1323-1330
    • O'Harte, F.P.M.1    Højrup, P.2    Barnett, C.R.3    Flatt, P.R.4
  • 22
    • 0033623237 scopus 로고    scopus 로고
    • Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues
    • McKillop AM, McCluskey JT, Boyd AC, Mooney MH, Flatt PR, O'Harte FPM. Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues. J Endocrinol, 2000, 167, 153-163.
    • (2000) J Endocrinol , vol.167 , pp. 153-163
    • McKillop, A.M.1    McCluskey, J.T.2    Boyd, A.C.3    Mooney, M.H.4    Flatt, P.R.5    O'Harte, F.P.M.6
  • 23
    • 0029806854 scopus 로고    scopus 로고
    • Reaction of rabbit skeletal myosin with D-glucose 6-phosphate
    • Avigad G, Kniep A, Bailin G. Reaction of rabbit skeletal myosin with D-glucose 6-phosphate. Biochem Mol Biol Int, 1996, 40, 273-284.
    • (1996) Biochem Mol Biol Int , vol.40 , pp. 273-284
    • Avigad, G.1    Kniep, A.2    Bailin, G.3
  • 24
    • 0031047710 scopus 로고    scopus 로고
    • Glycation of insulin by phosphorylated and non-phosphorylated reducing sugars
    • Abstract
    • O'Harte FPM, Penney AC, Flatt PR. Glycation of insulin by phosphorylated and non-phosphorylated reducing sugars. [Abstract] Biochem Soc Trans, 1997, 25, 150S.
    • (1997) Biochem Soc Trans , vol.25
    • O'Harte, F.P.M.1    Penney, A.C.2    Flatt, P.R.3
  • 26
    • 0012368523 scopus 로고    scopus 로고
    • Detection of glycated insulin in plasma of type 2 diabetic subjects
    • Abstract
    • McKillop AM, McGurk C, McCluskey JT, et al. Detection of glycated insulin in plasma of type 2 diabetic subjects. [Abstract] Digestion, 1999, 60, 507.
    • (1999) Digestion , vol.60 , pp. 507
    • McKillop, A.M.1    McGurk, C.2    McCluskey, J.T.3
  • 27
    • 12244311569 scopus 로고    scopus 로고
    • Development and use of a specific radioimmunoassay for detection of glycated insulin in diabetes
    • Abstract
    • O'Harte FPM, McKillop AM, Mooney MH, Flatt PR. Development and use of a specific radioimmunoassay for detection of glycated insulin in diabetes. [Abstract] Diabetologia, 2000, 43 (Suppl. 1), A52.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • O'Harte, F.P.M.1    McKillop, A.M.2    Mooney, M.H.3    Flatt, P.R.4
  • 28
    • 0024433534 scopus 로고
    • A self regulating insulin delivery system. 2. In vivo characteristics of synthetic glycosylated insulin
    • Seminoff LA, Gleeson JM, Zheng J, et al. A self regulating insulin delivery system. 2. In vivo characteristics of synthetic glycosylated insulin. Int J Pharm, 1989, 54, 251-257.
    • (1989) Int J Pharm , vol.54 , pp. 251-257
    • Seminoff, L.A.1    Gleeson, J.M.2    Zheng, J.3
  • 29
    • 0018387812 scopus 로고
    • Preparation and biological properties of glycosylated insulin
    • Dolhofer R, Wieland OH. Preparation and biological properties of glycosylated insulin. FEBS Letters, 1979, 100, 133-136.
    • (1979) FEBS Letters , vol.100 , pp. 133-136
    • Dolhofer, R.1    Wieland, O.H.2
  • 30
    • 0024274030 scopus 로고
    • Reduced in vivo biological activity of in vitro glycosylated insulin
    • Lapolla A, Tessari P, Poli T, et al. Reduced in vivo biological activity of in vitro glycosylated insulin. Diabetes, 1988, 37, 787-791.
    • (1988) Diabetes , vol.37 , pp. 787-791
    • Lapolla, A.1    Tessari, P.2    Poli, T.3
  • 31
    • 12244300238 scopus 로고    scopus 로고
    • Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycaemic clamp technique in man
    • in press
    • Hunter SJ, Boyd AC, O'Harte FPM, et al. Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycaemic clamp technique in man. Diabetes (in press).
    • Diabetes
    • Hunter, S.J.1    Boyd, A.C.2    O'Harte, F.P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.