Pentylenetetrazole affects metabolism of astrocytes in culture

Journal of Neuroscience Research

Volumn 79, Issue 1-2, 2005, Pages 48-54

  Qu, Hong ^a   Eloqayli, Haytham ^a   Sonnewald, Ursula ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Astrocytes; Glucose; Glutamate; Metabolism; PTZ

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ASPARTIC ACID; CARBON 13; CELL PROTEIN; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; LACTATE DEHYDROGENASE; LACTIC ACID; PENTETRAZOLE;

ANIMAL CELL; ASTROCYTE; BRAIN CORTEX; BRAIN METABOLISM; BRAIN MITOCHONDRION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL METABOLISM; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; GLUCOSE METABOLISM; GLYCOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; CARBON ISOTOPES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; GLUCOSE; GLUTAMIC ACID; L-LACTATE DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PENTYLENETETRAZOLE; PROTEINS; TIME FACTORS;

EID: 12244286061     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20306     Document Type: Conference Paper

References (35)

1. Avola R, Mignini F, Mazzone V, Fisichella A, Zaccheo D, Tomassoni D. 2004. Growth factor-estradiol interaction on DNA labeling and cytoskeletal protein expression in cultured rat astrocytes. Neurosci Lett 358:177-180.
2. Backus KH, Kettenmann H, Schachner M. 1988. Effect of benzodiazepines and pentobarbital on the GABA-induced depolarization in cultured astrocytes. Glia 1:132-140.
3. Bergmeyer HU. 1972. Standardization of enzyme assays. Clin Chem 18:1305-1311.
4. Berl S, Clark DD. 1983. The metabolic compartmentation concept. In: Hertz L, Kvamme E, McGeer EG, Schousboe A, editors. Neurology and neurobiology. Vol 7. Glutamine, glutamate and GABA in the central nervous system. New York: Alan R. Liss, Inc. p 215-217.
5. - channels in cultured astrocytes. Proc Natl Acad Sci USA 85:9336-9340.
6. Chvatal A, Kettenmann H. 1991. Effect of steroids on gamma-aminobutyrate- induced currents in cultured rat astrocytes. Pflugers Arch 419:263-266.
7. Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65:1-105.
8. 13C] glucose in cultured cerebellar granule neurons. Neurochem Int 40:181-187.
9. Fisher RS. 1989. Animal models of the epilepsies. Brain Res Brain Res Rev 14:245-278.
10. Fonnum F. 1984. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42:1-11.
11. A/benzodiazepine receptors in acutely isolated hippocampal astrocytes. J Neurosci 15:2720-2732.
12. Gilbert P, Kettenmann H, Schachner M. 1984. γ-Aminobutyric acid directly depolarizes cultured oligodendrocytes. J Neurosci 4:561-569.
13. Gomes FC, Paulin D, Moura Neto V. 1999. Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation. Braz J Med Biol Res 32:619-631.
14. Hertz L, Juurlink BHJ, Hertz E, Fosmark H, Schousboe A. 1989. Preparation of primary cultures of mouse (rat): astrocytes. In: Shahar A, De Vellis J, Vernadakis A, Haber B, editors. A dissection and tissue culture manual for the nervous system. New York: Alan R. Liss, Inc. p 105-108.
15. Huxtable RJ. 1992. Physiological actions of taurine. Physiol Rev 72:101-163.
16. A receptors in cultured rat astrocytes. Neurosci Lett 126:9-12.
17. Kettenmann H, Backus KH, Schachner M. 1984. Aspartate, glutamate and γ-aminobutyric acid depolarize cultured astrocytes. Neurosci Lett 52:25-29.
18. Lai JC, Leung TK, Lim L. 1994. Heterogeneity of monoamine oxidase activities in synaptic and nonsynaptic mitochondria derived from three brain regions: some functional implications. Metab Brain Dis 9:53-66.
19. Leong SF, Lai JC, Lim L, Clark JB. 1984. The activities of some energy-metabolising enzymes in nonsynaptic (free) and synaptic mitochondria derived from selected brain regions. J Neurochem 42:1306-1312.
20. 1H NMR. J Biol Chem 271:10648-10653.
21. Matsutani S, Yamamoto N. 1997. Neuronal regulation of astrocyte morphology in vitro is mediated by GABAergic signaling. Glia 20:1-9.
22. Owens DF, Kriegstein AR. 2002. Is there more to GABA than synaptic inhibition? Nat Rev Neurosci 3:715-727.
23. 31P nuclear magnetic resonance spectroscopic studies of bicuculline-induced seizures in vivo. Ann Neurol 20:185-193.
24. Qu H, Faero E, Jorgensen P, Dale O, Gisvold SE, Unsgard G, Sonnewald U. 1999. Decreased glutamate metabolism in cultured astrocytes in the presence of thiopental. Biochem Pharmacol 58:1075-1080.
25. 13C] glutamate metabolism in cerebellar astrocytes and granule neurons. J Neurosci Pes 66:885-890.
26. Qu H, Syversen T, Aschner M, Sonnewald U. 2003. Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture. Neurochem Int 43:411-416.
27. Qu H, van der Gaag M, Le Maire T, Sonnewald U. 2001a. The effect of thiopental on glutamate metabolism in mouse cerebellar astrocytes in vitro. Neurosci Lett 304:141-144.
28. Raza M, Shaheen F, Choudhary MI, Rahman AU, Sombati S, DeLorenzo RJ. 2002. In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum. Neurosci Lett 333:103-106.
29. 13C magnetic resonance spectroscopy. Neurochem Int 45:305-310.
30. Verkhratsky A, Steinhäuser C. 2000. Ion channels in glial cells. Brain Res Brain Res Rev 32:380-412.
31. Vicario-Abejon C, Yusta-Boyo MJ, Fernandez-Moreno C, de Pablo F. 2003. Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci 23:895-906.
32. von Blankenfeld G, Trotter J, Kettenmann H. 1991. Expression and developmental regulation of a GABAA receptor in cultured murine cells of the oligodendrocyte lineage. Eur J Neurosci 3:310-316.
33. 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog. Ann Neurol 18:14-20.
34. Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I. 2003. Metabolism of brain amino acids following pentylenetetrazole treatment. Epilepsy Res 53:151-162.
35. 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes. Glia 34:200-212.