The biological effects of diagnostic cardiac imaging on chronically exposed physicians: The importance of being non-ionizing

Cardiovascular Ultrasound

Volumn 2, Issue , 2004, Pages

  Andreassi, Maria Grazia ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC IMAGING; DOSIMETRY; ELECTROPHYSIOLOGY; HEALTH CARE PERSONNEL; HEALTH HAZARD; HUMAN; IONIZING RADIATION; MEDICAL PERSONNEL; MEDICAL SPECIALIST; MEDICAL STAFF; OCCUPATIONAL EXPOSURE; PHYSICIAN; RELIABILITY; REVIEW; RISK; ULTRASOUND;

BODY BURDEN; CARDIOLOGY; DIAGNOSTIC IMAGING; HUMANS; OCCUPATIONAL EXPOSURE; PHYSICIANS; RADIATION DOSAGE; RADIATION INJURIES; RADIATION PROTECTION; RADIATION, IONIZING; RADIATION, NONIONIZING; RELATIVE BIOLOGICAL EFFECTIVENESS; RISK ASSESSMENT; RISK FACTORS;

EID: 12244282482     PISSN: 14767120     EISSN: None     Source Type: Journal    
DOI: 10.1186/1476-7120-2-25     Document Type: Review

References (72)

1. Higgins CB: Cardiac imaging. Radiology 2000, 217:4-10.
2. International Commission on Radiological Protection (ICRP): Radiation and your patient: a guide for medical practitioners. A web module produced by Committee 3 of the ICRP. Oxford, UK: Pergamon Press; 2001.
3. European Commission. Radiation protection 118: Referral guidelines for imaging. [http://europa.eu.int/comm/environment/rad prot/118/rp-118-en.pdf]. (accessed 23 July 2004)
4. Council Directive 97/43/Euratom of 30 June 1997 on health protection of individuals against the dangers of ionizing radiation in relation to medical exposure, and repealing Directive 84/466/Euratom. Official Journal of the European Communities L180:0022-0027. 09/07/1997
5. Picano E: Sustainability of medical imaging. Education and Debate. BMJ 2004, 328:578-580.
6. Shiralkar S, Rennie A, Snow M, Galland RB, Lewis MH, Gower-Thomas K: Doctors' knowledge of radiation exposure: questionnaire study. BMJ 2003, 327:371-372.
7. Finestone A, Schlesinger T, Amir H, Richter E, Milgrom C: Do physicians correctly estimate radiation risks from medical imaging? Arch Environ Health 2003, 58:59-61.
8. Lee CI, Haims AH, Monico EP, Brink JA, Forman HP: Diagnostic CT scans: assessment of patient, physician, and radiologist awareness of radiation dose and possible risks. Radiology 2004, 231:393-398.
9. Correia MJ, Hellies A, Andreassi MG, Ghelarducci B, Picano E: Lack of Radiological Awareness in a Tertiary Care Cardiological Centre. Int J Cardiol 2005 in press.
10. Nyborg WL: Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med Biol 2001, 27:301-333.
11. American Institute of Ultrasound in Medicine (Bioeffects Committee): Bioeffects considerations for the safety of diagnostic ultrasound. American Institute of Ultrasound in Medicine. J Ultrasound Med 1988, 7:S1-38.
12. Liebeskind D, Bases R, Elequin F, Neubort S, Leifer R, Goldberg R, Koenigsberg M: Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells. Radiology 1979, 131:177-184.
13. Fuciarelli AF, Sisk EC, Thomas RM, Miller DL: Induction of base damage in DNA solutions by ultrasonic cavitation. Free Radic Biol Me 1995, 18:231-238.
14. Miller MW, Wolff S, Filly R, Cox C, Carstensen EL: Absence of an effect of diagnostic ultrasound on sister-chromatid exchange induction in human lymphocytes in vitro. Mutat Res 1983, 120:261-268.
15. Stella M, Trevisan L, Montaldi A, Zaccaria G, Rossi G, Bianchi V, Levis AG: Related Induction of sister-chromatid exchanges in human lymphocytes exposed in vitro and in vivo to therapeutic ultrasound. Mutat Res 1984, 138:75-78.
16. Barnett SB, Barnstable SM, Kossoff G: Sister chromatid exchange frequency in human lymphocytes after long duration exposure to pulsed ultrasound. J Ultrasound Med 1987, 6:637-642.
17. Carrera P, Orsini S, Terzoli G, Brambati B, Simoni G: Sister chromatid exchanges in first-trimester chorionic villi after in vivo and in vitro exposure to diagnostic ultrasound. Prenat Diagn 1990, 10:141-158.
18. Miller MW, Azadniv M, Cox C, Miller WM: Lack of induced increase in sister chromatid exchanges in human lymphocytes exposed to in vivo therapeutic ultrasound. Ultrasound Med Biol 1991, 17:81-83.
19. Martin AO, Madsen EL, Dyer AR, White L, Bouck NP, Sabbagha RE, Hermanoff M, Chen JM, Ludtke LJ: Sister chromatid exchange analysis of human cells exposed to diagnostic levels of ultrasound. J Ultrasound Med 1991, 10:665-670.
20. Sahin O, Donmez-Altuntas H, Hizmetli S, Hamurcu Z, Imamoglu N: Investigation of genotoxic effect of ultrasound in cases receiving therapeutic ultrasound by using micronucleus method. Ultrasound Med Biol 2004, 30:545-548.
21. Nyborg WL: Human Exposure to ultrasound. Appl Occup Environ Hygn 1996, 11:251-254.
22. Garaj-Vrhovac V, Kopjar N: Cytogenetic monitoring of cardiology unit hospital workers exposed to Doppler ultrasound. J Appl Toxicol 2000, 20:259-264.
23. Beir V: Health effects of exposure to low levels of ionizing radiation. In Prepared by the Committee on the Biological Effects of Ionizing Radiation, National Research Council, Washington, DC National Academy Press; 1990.
24. Report of the United States Nations Scientific Committee on the Effects of Atomic Radiation to the General Assembly: Annex G: Biological effects at low radiation doses. USCEAR 2001.
25. Hall EJ: Radiobiology for the Radiologist. 5th edition. Lippincott Williams & Wilkins, Philadelphia, PA; 2000.
26. International Commission on Radiological Protection. ICRP Publication 59: The biological basis for dose limitation in the skin. Annals of the ICRP 1991:22.
27. National Radiological Protection Board: Risk from deterministic effects of ionizing radiation. In Documents of the National Radiological Protection Board 7 London: HMSO; 1996.
28. Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M: Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci USA 2003, 100:13761-13766.
29. National Council on Radiation Protection and Measurements: Evaluation of the Linear-Nonthreshold Dose-Response Model for Ionizing Radiation. NCRP, Bethesda 2001. Report No.136
30. Dubrova YE: Long-term genetic effects of radiation exposure. Mutat Res 2003, 544:433-439.
31. Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD: Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 1990, 300:423-429.
32. Hama Y, Uematsu M, Sakurai Y, Kusano S: Sex ratio in the offspring of male radiologists. Acad Radiol 2001, 8:421-424.
33. Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN: Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. Am J Hum Genet 2002, 71:801-809.
34. Kiuru A, Auvinen A, Luokkamaki M, Makkonen K, Veidebaum T, Tekkel M, Rahu M, Hakulinen T, Servomaa K, Rytomaa T, Mustonen R: Hereditary minisatellite mutations among the offspring of Estonian Chernobyl cleanup workers. Radiat Res 2003, 159:651-655.
35. Slebos RJ, Little RE, Umbach DM, Antipkin Y, Zadaorozhnaja TD, Mendel NA, Sommer CA, Conway K, Parrish E, Gulino S, Taylor JA: Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers. Mutat Res 2004, 559:143-151.
36. Regulla D, Griebel J, Nosske D, Bauer B, Brix G: Acquisition and assessment of patient exposure in diagnostic radiology and nuclear medicine. Z Med Phys 2003, 13:127-135.
37. Renaud L: A 5-year follow up of the radiation exposure to inroom personnel during cardiac catheterization. Health Phys 1992, 62:10-15.
38. Vano E, Gonzalez L, Beneytez F, Moreno F: Lens injuries induced by occupational exposure in non-optimised interventional radiology laboratories. Br J Radiol 1998, 71:728-733.
39. McKetty MH: Study of radiation doses to personnel in a cardiac catheterisation laboratory. Health Phys 1996, 70:563-567.
40. Finkelstein MM: Is brain cancer an occupational disease of cardiologists? Can J Cardiol 1998, 14:1385-1388.
41. Vano E: Radiation exposure to cardiologists: how it could be reduced. Heart 2003, 89:1123-1124.
42. Delichas M, Psarrakos K, Molyvda-Athanassopoulou E, Giannoglou G, Sioundas A, Hatziioannou K, Papanastassiou E: Radiation exposure to cardiologists performing interventional cardiology procedures. Eur J Radiol 2003, 48:268-273.
43. Kuon E, Birkel J, Schmitt M, Dahm JB: Radiation exposure benefit of a lead cap in invasive cardiology. Heart 2003, 89:1205-1216.
44. Berrington De Gonzalez A, Darby S: Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. Lancet 2004, 363:345-351.
45. Picano E: Risk of Cancer from diagnostic X-rays: impressive but underestimated. Lancet 2004, 363:1909-1910.
46. Yoshinaga S, Mabuchi K, Sigurdson AJ, Doody MM, Ron E: Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies. Radiology 2004, 233:313-321.
47. Gofman JW: Radiation from medical procedures in the pathogenesis of cancer and ischemic heart disease: dose-response studies with physicians per 100,000 population, San Francisco. Committee for Nuclear Responsibility Books, Available at UCSF Med. Library. The Exec Summary online 1999 [http://www.ratical.org/radiation/CNR/RMP/].
48. Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K: Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 2003, 160:381-407.
49. Bonassi S: Combining environmental exposure and genetic effect measurements in health outcome assessment. Mutat Res 1999, 428:177-185.
50. Pavanello S, Clonfero E: Biological indicators of genotoxic risk and metabolic polymorphisms. Mutat Res 2000, 463:285-308.
51. Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LS, Norppa H, Reuterwall C, European Study Group on Cytogenetic Biomarkers and Health: Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res 1998, 58:4117-4121.
52. Hagmar L, Stromberg U, Bonassi S, Hansteen IL, Knudsen LE, Lindholm C, Norppa H: Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res 2004, 64:2258-2263.
53. Fenech M: Biomarkers of genetic damage for cancer epidemiology. Toxicology 2002, 181-182:411-6.
54. Bigatti P, Lamberti L, Ardito G, Armellino F: Cytogenetic monitoring of hospital workers exposed to low-level ionizing radiation. Mutat Res 1988, 204:343-347.
55. Barquinero JF, Barrios L, Caballin MR, Miro R, Ribas M, Subias A, Egozcue J: Cytogenetic analysis of lymphocytes from hospital workers occupationally exposed to low levels of ionizing radiation. Mutat Res 1993, 286:275-279.
56. Paz-y-Mino C, Leone PE, Chavez M, Bustamante G, Cordova A, Gutierrez S, Penaherrera MS, Sanchez ME: Follow up study of chromosome aberrations in lymphocytes in hospital workers occupationally exposed to low levels of ionizing radiation. Mutat Res 1995, 335:245-251.
57. Vera GV, Aleksandra F, Dragan K, Andrija H: Assessment of genome damage in occupational exposure to ionizing radiation and ultrasound. Mutat Res 1997, 395:101-105.
58. Bonassi S, Forni A, Bigatti P, Canevarollo N, De Ferrari M, Lando C, Padovani P, Bevegni M, Stella M, Vecchio D, Puntoni R: Chromosome aberrations in hospital workers: evidence from surveillance studies in Italy (1963-1993). Am J Ind Med 1997, 31:353-360.
59. Rozgaj R, Kasuba V, Sentija K, Prlic I: Radiation-induced chromosomal aberrations and haematological alterations in hospital workers. Occup Med 1999, 49:353-360.
60. Undeger U, Zorlu AF, Basaran N: Use of the alkaline comet assay to monitor DNA damage in technicians exposed to low-dose radiation. J Occup Environ Med 1999, 41:693-698.
61. Cardoso RS, Takahashi-Hyodo S, Peitl P, Ghilardi-Neto T, Sakamoto-Hojo ET: Evaluation of chromosomal aberrations, micronuclei, and sister chromatid exchanges in hospital workers chronically exposed to ionizing radiation. Teratog Carcinog Mutagen 2001, 21:431-439.
62. Maluf SW, Passos DF, Bacelar A, Speit G, Erdtmann B: Assessment of DNA damage in lymphocytes of workers exposed to X-radiation using the micronucleus test and the comet assay. Environ Mol Mutagen 2001, 38:311-315.
63. Maffei F, Angelini S, Forti GC, Lodi V, Violante FS, Mattioli S, Hrelia P: Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: influence of smoking status and other factors. Mutagenesis 2002, 17:405-409.
64. Bozkurt G, Yuksel M, Karabogaz G, Sut N, Savran FO, Palanduz S, Yigitbasi ON, Algunes C: Sister chromatid exchange in lymphocytes of nuclear medicine physicians. Mutat Res 2003, 535:205-213.
65. Graj-Vrhovac Vera, Kopjar N: The alkaline Comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation. Mutagenesis 2003, 18:265-271.
66. Maffei F, Angelini S, Forti GC, Violante FS, Lodi V, Mattioli S, Hrelia P: Spectrum of chromosomal aberrations in peripheral lymphocytes of hospital workers occupationally exposed to low doses of ionizing radiation. Mutat Res 2004, 547:91-99.
67. Zakeri F, Assaei RG: Cytogenetic monitoring of personnel working in angiocardiography laboratories in Iran hospitals. Mutat Res 2004, 562:1-9.
68. Andreassi MG, Joksic G, Manfredi S, Alavantic D, Cioppa A, Botto N, Hellies A, Ostojic M, Rubino P, Picano E: omatic DNA damage in interventional cardiologists. Eur Heart J 2004, 25:570. (abstract)
69. Aka P, Mateuca R, Buchet JP, Thierens H, Kirsch-Volders M: Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? Mutat Res 2004, 556:169-181.
70. International Atomic Energy Agency (IAEA): Cytogenetic analysis for Radiation Dose Assessment. Technical Report 2001, 405:.
71. Fenech M, Gledhill BL, Mauro F, Ed: Optimisation of micronucleus assays for biological dosimetry. in New Horizons in Biological Dosimetry (Wiley, New York) 1981:373-376.
72. Bonassi S, Au WW: Biomarkers in molecular epidemiology studies for health risk prediction. Mutat Res 2002, 511:73-86.