Spectrum of chromosomal aberrations in peripheral lymphocytes of hospital workers occupationally exposed to low doses of ionizing radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 547, Issue 1-2, 2004, Pages 91-99

  Maffei, Francesca ^a   Angelini, Sabrina ^a   Forti, Giorgio Cantelli ^a   Violante, Francesco S ^b   Lodi, Vittorio ^b   Mattioli, Stefano ^b   Hrelia, Patrizia ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Chromosomal aberrations; Ionizing radiation; Lymphocytes; Occupational exposure

Indexed keywords

ADULT; ARTICLE; CHROMATID; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DICENTRIC CHROMOSOME; FEMALE; GENETIC DAMAGE; HOSPITAL PERSONNEL; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SEX DIFFERENCE; SMOKING HABIT; WHOLE BODY RADIATION;

ADULT; AGE DISTRIBUTION; ALLIED HEALTH PERSONNEL; CARDIOLOGY SERVICE, HOSPITAL; CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; FEMALE; GAMMA RAYS; HUMANS; LYMPHOCYTES; MALE; MEDICAL STAFF, HOSPITAL; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PERSONNEL, HOSPITAL; RADIATION DOSAGE; RADIATION, IONIZING; RADIOLOGY DEPARTMENT, HOSPITAL; SEX DISTRIBUTION; SMOKING; X-RAYS;

EID: 1542345764     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2003.12.003     Document Type: Article

References (50)

1. Breimer L.H. Ionizing radiation-induced mutagenesis. Br. J. Cancer. 57:1988;6-18.
2. Morgan W.F., Day J.P., Kaplan M.I., McGheee E.M., Limoli C.L. Genomic instability induced by ionizing radiation. Radiat. Res. 146:1996;247-258.
3. Perera F.P., Hemminki K., Grzybowska E., Motykiewicz G., Michalska J., Santella R.M., Young T.L., Dickey C., Brandt-Rauf P., Chorazy M. Molecular and genetic damage from environmental pollution in Poland. Nature. 360:1992;256-258.
4. Perera F.P., Whyatt R.M. Biomarkers and molecular epidemiology in mutation/cancer research. Mutat. Res. 313:1994;117-129.
5. Hagmar L., Brøgger A., Hansteen I.L., Heim S., Högstedt B., Knudsen L., Lambert B., Linnainmaa K., Mitelman F., Sorsa M. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic Study Group on the Health Risk of Chromosome Damage. Cancer Res. 54:1994;2919-2922.
6. Hagmar L., Bonassi S., Strömberh U., Mikoczy Z., Lando C., Hansteen I.L., Montagud A.H., Knudsen L., Norppa H., Skerfving S. Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health. Mutat. Res. 405:1998;171-178.
7. Bonassi S., Hagmar L., Strömberg U., Montagud A.H., Tinnerberg H., Forni A., Heikkiliä P., Wanders S., Wilhardt P., Norppa H. Chromosomal aberrations in lymphocytes predict human cancer indipendently of exposure to carcinogens. Cancer Res. 60:2000;1619-1625.
8. Bauchinger M. Quantification of low level radiation exposure by conventional chromosome aberration analysis. Mutat. Res. 339:1995;177-189.
9. Awa A.A., Sofuni T., Honda T., Itch T., Neriishi S., Otake K. Relationship between the radiation dose and chromosome aberrations in atomic bomb survivors of Hiroshima and Nagasaki. J. Radiat. Res. 19:1978;126-140.
10. Ramalho A.T., Nascimento R.C.H., Natarajan A.T. Dose assessment by cytogenetic analysis in the Goiania (Brazil) radiation accident. Radiat. Prot. Dosim. 25:1988;97-100.
11. A.A. Awa, Chromosome aberrations in A-bomb survivors, Hiroshima and Nagasaki, in: G. Obe, A.T. Natarajan (Eds.), Chromosomal Aberrations, Basic and Applied Aspects, Springer, Berlin, 1990, pp. 150-180.
12. J. Pohl-Rüling, P. Fischer, Chromosome aberrations in inhabitants of area with elevated natural radioactivity, in: T. Ishihara, M. Sasaki (Eds.), Radiation-induced Chromosome Damage in Man, Liss, New York, 1983, pp. 527-560.
13. Wang-Wuu S., Tai J.J., Wuu J., Lin S.Y., Chen W.L., Wuu K.D. Chromosome aberrations in lymphocytes of residents living in building constructed with radioactively contaminated rebars. J. Biomed. Sci. 8:2001;411-415.
14. Evans H.J., Buckton J., Hamilton K.E., Carothers G.E. A radiation-induced chromosome aberrations in nuclear dockyard workers. Nature. 222:1979;531-534.
15. Bauchinger M., Kolin-Genesheim J., Schmid E., Dresp J. Chromosome analysis of nuclear power plant workers. Int. J. Radiat. Biol. 38:1980;577-581.
16. Lloyd D.C., Purrott R.J., Reeder E.J. The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people. Mutat. Res. 72:1980;523-532.
17. Bauchinger M., Eckerl H., Drexler G., Streng S., Schmid E. Chromosome dosimetry and occupational radiation exposure. Radiat. Prot. Dosim. 2:1984;93-97.
18. Bigatti P., Lamberti L., Ardito G., Armellino F. Cytogenetic monitoring of hospital workers exposed to low level ionizing radiation. Mutat. Res. 204:1988;343-347.
19. Jha A.N., Sharma T. Enhanced frequency of chromosome aberrations in workers occupationally exposed to diagnostic X-ray. Mutat. Res. 260:1991;343-348.
20. Balasem A.N., Ali A.S.K., Mosa H.S., Hussian K.O. Chromosomal aberration analysis in peripheral lymphocytes of radiation workers. Mutat. Res. 271:1992;209-211.
21. Barquinero J.F., Barrios L., Caballin M.R., Miro R., Ribas M., Subias A., Egozcue J. Cytogenetic analysis of lymphocytes from hospital workers occupationally exposed to low level of ionizing radiation. Mutat. Res. 286:1993;275-279.
22. Chung H.W., Ryu E.K., Kim Y.J., Ha S.W. Chromosome aberrations in workers of nuclear-power plants. Mutat. Res. 350:1996;307-314.
23. Bonassi S., Forni A., Bigatti P., Canevarollo N., De Ferrari M., Lando C., Padovani P., Bevegni M., Stella M., Vecchio D., Puntoni R. Chromosome aberrations in hospital workers: evidence from surveillance studies in Italy (1963-1993). Am. J. Ind. Med. 31:1997;353-360.
24. Balakrishnan S., Rao S.B. Cytogenetic analysis of peripheral blood lymphocytes of occupational workers exposed to low levels of ionizing radiation. Mutat. Res. 442:1999;37-42.
25. Lazutka J.R., Lekevicius R., Dedonytè V., Maciuleviciute-Gerves L., Mierauskine J., Rudaitiene S., Slapsyte G. Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: effects of occupational and environmental exposures. Mutat. Res. 445:1999;225-239.
26. Rozgaj R., Kasuba V., Sentija K., Prliè I. Radiation-induced chromosomal aberrations and haematological alterations in hospital workers. Occup. Med. 49:1999;353-360.
27. Cardoso R.S., Takahashi-Hyodo S., Ghilardi-Neto P.T., Sakamoto-Hojo E.T., Peitil P. Jr. Evaluation of chromosomal aberrations, micronuclei, and sister-chromatid exchanges in hospital workers chronically exposed to ionizing radiation. Teratot. Carcinog. Mutagen. 21:2001;431-439.
28. Gazzetta Ufficiale 1997, no. 5, S.O. Law no. 675, 1996: Tutela delle persone e di altri soggetti rispetto al trattamento dei dati personali.
29. Gazzetta Ufficiale 1995, no. 136, S.O. Law no. 230, 1995: Attuazione delle direttive Euratom 80/835, 84/466, 84/667, 89/618, 90/641, 92/3 in materia di radiazioni ionizzanti.
30. Council Directive 84/466/Euratom of 3 September 1984 laying down basic measures for the radiation protection of persons undergoing medical examination or treatment.
31. Stata Corporation, Stata Statistical Software: Release 6.0, Stata Corporation, College Station, Texas, 1999.
32. J. Purrott, D.C. Lloyd, J.S. Prosser, G.M. Dolphin, E.J. Elthan, P.A. Tipper, C.M. White, S.J. Copper, The study of chromosome aberration yield in human lymphocytes as an indicator of radiation dose. IV. A review of cases investigated. NRPB-R 23, UK National Radiology Protection Board, Harwell, 1973.
33. Bryant P.E. The signal model: a possible explanation for conversion of DNA double-strand breaks into chromatid breaks. Int. J. Radiat. Biol. 73:1998;243-251.
34. Bryant P.E. Mechanisms of radiation-induced chromatid breaks. Mutat. Res. 404:1998;107-111.
35. Galloway S.M., Berry P.K., Nichols W.W., Wolman S.R., Soper K.A., Stolley P.D., Archer P. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. Mutat. Res. 170:1986;55-74.
36. Anderson D., Jenkinson P.C., Dewdney R.S., Francis A.J., Godbert P., Buterworth K.R. Chromosome aberration, mitogen-induced blastogenesis and proliferate rate index in peripheral lymphocytes from 106 control individuals of the UK population. Mutat. Res. 204:1988;407-420.
37. Milillo C.P., Gemignani F., Sbrana I., Carozzi L., Viegi G., Barale R. Chromosome aberrations in humans in relation to site of residence. Mutat. Res. 346:1996;187-193.
38. Au W.W., Cajas-Salazar N., Salama S. Factors contributing to discrepancies in population monitoring studies. Mutat. Res. 400:1998;467-478.
39. Bonassi S., Neri M., Lando C., Ceppi M., Lin Y., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Fenech M. Effect of smoking habit on the frequency of micronuclei inhuman lymphocytes: resuls from the human micronucleus project. Mutat. Res. 543:2003;155-166.
40. daCruz A.D., McArthur A.G., Silva C.C., Curado M.P., Glickman B.W. Human micronucleus counts are correlated with age, smoking and cesium-137 dose in the Goiania (Brazil) radiological accident. Mutat. Res. 313:1994;57-68.
41. Slozina N., Neronova E., Kharchenko T., Nikiforov A. Increased level of chromosomal aberrations in lymphocytes of Chernobyl liquidators 6-10 years after the accident. Mutat. Res. 379:1997;121-125.
42. Wang L.E., Bondy M.L., de Andrade M., Strom S.S., Wang X., Sigurdson A., Spitz M.R., Wei Q. Gender difference in smoking effect on chromosome sensitivity to gamma radiation in a healthy population. Radiat. Res. 154:2000;20-27.
43. Au W.W., Walker D.M., Ward J.B., Whorton E., Legator M.S., Singh V. Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Mutat. Res. 260:1991;137-144.
44. Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C., Shelbey M.D. Chromosomal aberration and sister-chromatid exchanges frequencies in peripheral blood lymphocytes of a large human population sample. Mutat. Res. 294:1988;421-433.
45. Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C. Chromosomal aberration and sister-chromatid exchanges frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of an age range. Mutat. Res. 212:1989;149-154.
46. Carbonel E., Peris F., Xa N., Creus A., Marcos R. Chromosomal analysis in 85 control individuals. Mutat. Res. 370:1996;29-37.
47. Bolognesi C., Abbondandolo A., Barale R., Canalone R., Dalpra L., De Ferrari M., Degrassi F., Forni A., Lamberti L., Bonassi S. Age-related increase of sister-chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol. Biomarkers Prev. 4:1997;249-256.
48. Bonassi S., Bolognesi C., Abbondandolo A., Barale R., Bigatti P., Cimurri L., Dalpra L., De Ferrari M., Forni A., Lando C. Influence of sex on cytogenetic end points: evidence from a large human sample and review of the literature. Cancer Epidemiol. Biomarkers Prev. 4:1995;671-679.
49. Kašuba V., Šentija K., Garaj-Vrhovac V., Fulčić A. Chromosome aberrations in perièheral blood lymphocytes from control individuals. Mutat. Res. 346:1995;187-193.
50. Stephan G., Pressl S. Chromosomal aberrations in peripheral lymphocytes from healthy subjects as detected in first cell division. Mutat. Res. 446:1999;231-237.