Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 8, 2003, Pages 1769-1780

  Zhou, Zhang Lin ^a   Kher, Sunil M ^a   Cai, Sui Xiong ^b   Whittemore, Edward R ^b   Espitia, Stephen A ^b   Hawkinson, Jon E ^b   Tran, Minhtam ^b   Woodward, Richard M ^b   Weber, Eckard ^b   Keana, John F W ^a  

^a UNIVERSITY OF OREGON   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 6,9 DIHYDRO 3H OXA 6,9 DIAZACYCLOPENTA[A]NAPHTHALENE 1,7,8 TRIONE; 5 BENZOYL 7 CHLORO 1,4 DIHYDROQUINOXALINE 2,3 DIONE; 5,7 DICHLOROKYNURENIC ACID; 6 CHLORO 1,4,7,8 TETRAHYDROCYCLOPENTA[F]QUINOXALINE 2,3,9 TRIONE; 6,7 DICHLORO 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALINE 5 CARBONITRILE; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; 7 CHLORO 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLIC ACID; 7 CHLORO 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLIC ACID DIETHYLAMIDE; 7 CHLORO 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 CHLORO 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALINE 5 CARBONITRILE; 7 CHLORO 6 METHYL 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALINE 5 CARBONITRILE; 7 METHYL 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLIC ACID; 7 NITRO 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLIC ACID; GLYCINE; METHYL 7 BROMO 6 METHYL 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLATE; METHYL 7 CHLORO 1,4 DIHYDROQUINOXALINE 2,3 DIONE 5 CARBOXYLATE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRO DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; IC 50; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; SEIZURE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 12244278327     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00059-2     Document Type: Article

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