Synthesis and structure-activity relationships of 1,2,3,4- tetrahydroquinoline-2,3,4-trione 3-oximes: Novel and highly potent antagonists for NMDA receptor glycine site

Journal of Medicinal Chemistry

Volumn 39, Issue 17, 1996, Pages 3248-3255

  Cai, Sui Xiong ^a   Zhou, Zhang Lin ^b   Huang, Jin Cheng ^a   Whittemore, Edward R ^a   Egbuwoku, Zizi O ^a   Lü, Yixin ^b   Hawkinson, Jon E ^a   Woodward, Richard M ^a   Weber, Eckard ^a   Keana, John F W ^b  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROQUINOLINE DERIVATIVE; 5,7 DICHLOROKYNURENIC ACID; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; DIZOCILPINE; GLUTAMIC ACID; GLYCINE; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINOXALINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; NONHUMAN; OOCYTE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; BRAIN; CELL MEMBRANE; CEREBRAL CORTEX; CLONING, MOLECULAR; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLYCINE; KINETICS; KYNURENIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OOCYTES; OXIMES; QUINOLINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0000039703     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960214k     Document Type: Article

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