Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection

Virology

Volumn 304, Issue 2, 2002, Pages 187-196

  Masciopinto, Francesca ^a   Freer, Giulia ^b   Burgio, Vito L ^c   Levy, Shoshana ^d   Galli Stampino, Luisa ^a   Bendinelli, Mauro ^b   Houghton, Michael ^e   Abrignani, Sergio ^a,e   Uematsu, Yasushi ^a  

^a CHIRON VACCINES   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Animal model; CD81; Hepatitis C virus; Infection; Transgenic mice

Indexed keywords

CD81 ANTIGEN; GLYCOPROTEIN; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DISEASE RESISTANCE; HEPATITIS C; HEPATITIS C VIRUS; INFECTION SENSITIVITY; INOCULATION; LIVER; LYMPHOCYTE; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; THYMOCYTE; TRANSGENIC MOUSE; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALIA; HEPATITIS C VIRUS; MUS MUSCULUS; PAN TROGLODYTES;

EID: 12244260821     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1631     Document Type: Article

References (37)

1. Agnello, V., Abel, G., Elfahal, M., Knight, G. B., and Zhang, Q. X. (1999). Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA 96, 12766-12771.
2. Allander, T., Forns, X., Emerson, S. U., Purcell, R. H., and Bukh, J. (2000). Hepatitis C virus envelope protein E2 binds to CD81 of tamarins. Virology 277, 358-367.
3. Arnheiter, H., and Meier, E. (1990). Mx proteins: Antiviral proteins by chance or by necessity? New Biol. 2, 851-857.
4. Bertolini, L., Iacovacci, S., Ponzetto, A., Gorini, G., Battaglia, M., and Carloni, G. (1993). The human bone-marrow-derived B-cell line CE, susceptible to hepatitis C virus infection. Res. Virol. 144, 281-285.
5. Cribier, B., Schmitt, C., Bingen, A., Kirn, A., and Keller, F. (1995). In vitro infection of peripheral blood mononuclear cells by hepatitis C virus. J. Gen. Virol. 76, 2485-2491.
6. Dash, S., Halim, A. B., Tsuji, H., Hiramatsu, N., and Gerber, M. A. (1997). Transfection of HepG2 cells with infectious hepatitis C virus genome. Am. J. Pathol. 151, 363-373.
7. Fournier, C., Sureau, C., Coste, J., Ducos, J., Pageaux, G., Larrey, D., Domergue, J., and Maurel, P. (1998). In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus. J. Gen. Virol. 79, 2367-2374.
8. Freer, G., Florio, W., Dalla Casa, B., Castagna, B., Maisetta, G., Batoni, G., Corsini, V., Senesi, S., and Campa, M. (1998). Characterization of antigens recognized by new monoclonal antibodies raised against culture filtrate proteins of Mycobacterium bovis bacillus Calmette-Guérin. FEMS Immunol. Med. Microbiol. 20, 129-138.
9. Garson, J. A., Whitby, K., Watkins, P., and Morgan, A. J. (1997). Lack of susceptibility of the cottontop tamarin to hepatitis C infection. J. Med. Virol. 52, 286-288.
10. Heile, J. M., Fong, Y. L., Rosa, D., Berger, K., Saletti, G., Campagnoli, S., Bensi, G., Capo, S., Coates, S., Crawford, K., Dong, C., Wininger, M., Baker, G., Cousens, L., Chien, D., Ng, P., Archangel, P., Grandi, G., Houghton, M., and Abrignani, S. (2000). Evaluation of hepatitis C virus glycoprotein E2 for vaccine design: An endoplasmic reticulum-retained recombinant protein is superior to secreted recombinant protein and DNA-based vaccine candidates. J. Virol. 74, 6885-6892.
11. Iacovacci, S., Manzin, A., Barca, S., Sargiacomo, M., Serafino, A., Valli, M. B., Macioce, G., Hassan, H. J., Ponzetto, A., Clementi, M., Peschle, C., and Carloni, G. (1997). Molecular characterization and dynamics of hepatitis C virus replication in human fetal hepatocytes infected in vitro. Hepatology 26, 1328-1337.
12. Ikeda, M., Sugiyama, K., Mizutani, T., Tanaka, T., Tanaka, K., Sekihara, H., Shimotohno, K., and Kato, N. (1998). Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus. Virus Res. 56, 157-167.
13. Kato, N., Ikeda, M., Sugiyama, K., Mizutani, T., Tanaka, T., and Shimotohno, K. (1998). Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro. J. Gen. Virol. 79, 1859-1869.
14. Kitadokoro, K., Galli, G., Petracca, R., Falugi, F., Grandi, G., and Bolognesi, M. (2001). Crystallization and preliminary crystallographic studies on the large extracellular domain of human CD81, a tetraspanin receptor for hepatitis C virus. Acta Crystallogr. D Biol. Crystallogr. 57, 156-158.
15. Lanford, R. E., Sureau, C., Jacob, J. R., White, R., and Fuerst, T. R. (1994). Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR. Virology 202, 606-614.
16. Levy, S., Todd, S. C., and Maecker, H. T. (1998). CD81 (TAPA-1): A molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16, 89-109.
17. Maecker, H. T., and Levy, S. (1997). Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J. Exp. Med. 185, 1505-1510.
18. Maecker, H. T., Todd, S. C., Kim, E. C., and Levy, S. (2000). Differential expression of murine CD81 highlighted by new anti-mouse CD81 monoclonal antibodies. Hybridoma 19, 15-22.
19. Maecker, H. T., Todd, S. C., and Levy, S. (1997). The tetraspanin superfamily: Molecular facilitators. FASEB J. 11, 428-442.
20. Marson, P., Boschetto, R., De Silvestro, G., Martini, S., Gabelli, C., Buoro, S., Giordano, R., and Palu, G. (1999). Changes in HCV viremia following LDL apheresis in a HCV positive patient with familial hypercholesterolemia. Int. J. Artif. Organs 22, 640-644.
21. Meola, A., Sbardellati, A., Bruni Ercole, B., Cerretani, M., Pezzanera, M., Ceccacci, A., Vitelli, A., Levy, S., Nicosia, A., Traboni, C., McKeating, J., and Scarselli, E. (2000). Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J. Virol. 74, 5933-5938.
22. Miyazaki, T., Muller, U., and Campbell, K. S. (1997). Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 16, 4217-4225.
23. Monazahian, M., Bohme, I., Bonk, S., Koch, A., Scholz, C., Grethe, S., and Thomssen, R. (1999). Low density lipoprotein receptor as a candidate receptor for hepatitis C virus. J. Med. Virol. 57, 223-229.
24. Morrica, A., Giorgi, M., Maggi, F., Fornai, C., Vatteroni, M. L., Marchi, S., Ricchiuti, A., Antonelli, G., Pistello, M., and Bendinelli, M. (1999). Susceptibility of human and non-human cell lines to HCV infection as determined by the centrifugation-facilitated method. J. Virol. Methods 77, 207-215.
25. Niwa, H., Yamamura, K., and Miyazaki, J. (1991). Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199.
26. Petracca, R., Falugi, F., Galli, G., Norais, N., Rosa, D., Campagnoli, S., Burgio, V., Di Stasio, E., Giardina, B., Houghton, M., Abrignani, S., and Grandi, G. (2000). Structure-function analysis of hepatitis C virus envelope-CD81 binding. J. Virol. 74, 4824-4830.
27. Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A. J., Houghton, M., Rosa, D., Grandi, G., and Abrignani, S. (1998). Binding of hepatitis C virus to CD81. Science 282, 938-941.
28. Rosa, D., Campagnoli, S., Moretto, C., Guenzi, E., Cousens, L., Chin, M., Dong, C., Weiner, A. J., Lau, J. Y., Choo, Q. L., Chien, D., Pileri, P., Houghton, M., and Abrignani, S. (1996). A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc. Natl. Acad. Sci. USA 93, 1759-1763.
29. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). "Molecular Cloning-A Laboratory Manual" 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
30. Seipp, S., Mueller, H. M., Pfaff, E., Stremmel, W., Theilmann, L., and Goeser, T. (1997). Establishment of persistent hepatitis C virus infection and replication in vitro. J. Gen. Virol. 78, 2467-2476.
31. Shimizu, Y. K., Igarashi, H., Kiyohara, T., Shapiro, M., Wong, D. C., Purcell, R. H., and Yoshikura, H. (1998). Infection of a chimpanzee with hepatitis C virus grown in cell culture. J. Gen. Virol. 79, 1383-1386.
32. Shimizu, Y. K., and Yoshikura, H. (1994). Multicycle infection of hepatitis C virus in cell culture and inhibition by alpha and beta interferons. J. Virol. 68, 8406-8408.
33. Tagawa, M., Kato, N., Yokosuka, O., Ishikawa, T., Ohto, M., and Omata, M. (1995). Infection of human hepatocyte cell lines with hepatitis C virus in vitro. J. Gastroenterol. Hepatol. 10, 523-527.
34. Tedder, T. F., Wagner, N., and Engel, P. (1995). CD81 Workshop report. In "Leukocyte Typing V" (S. F. Schlossman, L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T. F. Tedder, and R. F. Todd, Eds.), Vol. 1, pp. 684-688. Oxford Univ. Press, Oxford.
35. Tsitsikov, E. N., Gutierrez-Ramos, J. C., and Geha, R. S. (1997). Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc. Natl. Acad. Sci. USA 94, 10844-10849.
36. Valli, M. B., Bertolini, L., Iacovacci, S., Ponzetto, A., and Carloni, G. (1995). Detection of a 5′ UTR variation in the HCV genome after a long-term in vitro infection. Res. Virol. 146, 285-288.
37. Wunschmann, S., Medh, J. D., Klinzmann, D., Schmidt, W. N., and Stapleton, J. T. (2000). Characterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor. J. Virol. 74, 10055-10062.