Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells

Journal of Ethnopharmacology

Volumn 84, Issue 1, 2003, Pages 85-89

  Oh, G S ^a   Pae, H O ^a   Choi, B M ^a   Jeong, S ^a   Oh, H ^b   Oh, C S ^b   Rho, Y D ^b   Kim, D H ^b   Shin, M K ^b   Chung, Hun Taeg ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

1,2,3,4,6 Penta O galloyl beta D glucose; Anti inflammation; Interleukin 8; Macrophage chemoattractant protein 1; Paeonia suffruticosa Andrews

Indexed keywords

1,2,3,4,6 PENTA O GALLOYL BETA DEXTRO GLUCOSE; ANTIINFLAMMATORY AGENT; BENZOYLPAEONIFLORIN; CHEMOKINE; INTERLEUKIN 8; MACROPHAGE CHEMOTACTIC FACTOR; PAEONIA SUFFRUTICOSA EXTRACT; PAEONIFLORIGENOME; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CELL STRAIN U937; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; GENE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MACROPHAGE; MEDICINAL PLANT; MONOCYTE; NEUTROPHIL; NONHUMAN; PAEONIA SUFFRUTICOSA; PLANT ROOT; PROTEIN SECRETION; ROOT CORTEX;

ANTI-INFLAMMATORY AGENTS; CHEMOKINE CCL2; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-8; MEDICINE, ORIENTAL TRADITIONAL; MONOCYTES; PAEONIA; PLANT EXTRACTS; PLANT ROOTS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; U937 CELLS;

EID: 12244257573     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00285-4     Document Type: Article

References (19)

1. Au T.K., Lam T.L., Ng T.B., Fong W.P., Wan D.C. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. Life Science. 68:2001;1687-1694.
2. Baggiolini M., Loetscher P., Moser B. Interleukin-8 and the chemokine family. International Journal of Immunopharmacology. 17:1995;103-108.
3. Clark-Lewis I., Kim K.S., Rajarathnam K., Gong J.H., Dewald B., Moser B., Baggiolini M., Sykes B.D. Structure-activity relationships of chemokines. Journal of Leukocyte Biology. 57:1995;703-711.
4. Frangogiannis N.G., Smith C.W., Entman M.L. The inflammatory response in myocardial infarction. Cardiovascular Research. 53:2002;31-47.
5. Hsiang C.Y., Hsieh C.L., Wu S.L., Lai I.L., Ho T.Y. Inhibitory effect of anti-pyretic and anti-inflammatory herbs on herpes simplex virus replication. American Journal of Chinese Medicne. 29:2001;459-467.
6. Lin H.C., Ding H.Y., Wu T.S., Wu P.L. Monoterpene glycosides from Paeonia suffruticosa. Phytochemistry. 41:1996;237-242.
7. Lin H.C., Ding H.Y., Wu Y.C. Two novel compounds from Paeonia suffructicosa. Journal of Natural Products. 61:1998;343-346.
8. MacDermott R.P. Chemokines in the inflammatory bowel diseases. Journal of Clinical Immunology. 19:1999;266-272.
9. Mukaida N., Harada A., Matsushima K. Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions. Cytokine Growth Factor Review. 9:1998;9-23.
10. Nishizawa N., Yamagishi T., Nonaka G., Nishioka I. Structure of gallotannins in Paeoniae radix. Chemical and Pharmaceutical Bulletin. 28:1980;2850-2852.
11. Okubo T., Nagai F., Seto T., Satoh K., Ushiyama K., Kano I. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae radix. Biological and Pharmaceutical Bulletin. 23:2000;199-203.
12. Pan M.H., Lin-Shiau S.Y., Ho C.T., Lin J.H., Lin J.K. Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochemical Pharmacology. 59:2000;357-367.
13. Satoh K., Nagai F., Ushiyama K., Yasuda I., Seto T., Kano I. Inhibition of Na+, K(+)-ATPase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, a major constituent of both moutan cortex and Paeoniae radix. Biochemical Pharmacology. 53:1997;611-614.
14. Shi L., Fan P.S., Fang J.X., Han Z.X. Inhibitory effects of paeonol on experimental atherosclerosis and platelet aggregation of rabbit. Zhongguo Yao Li Xue Bao. 9:1988;555-558.
15. Shimizu M., Hayashi T., Morita N., Kiuchi F., Noguchi H., Ittaka Y., Sankawa U. The structure of paeoniflorigenone, a new monoterpene isolated from Paeoniae radix. Chemical and Pharmaceutical Bulletin. 31:1983;577-583.
16. Smith R.E., Hogaboam C.M., Strieter R.M., Lukacs N.W., Kunkel S.L. Cell-to-cell and cell-to-matrix interactions mediate chemokine expression: an important component of the inflammatory lesion. Journal of Leukocyte Biology. 62:1997;612-619.
17. Stanimirovic D., Satoh K. Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation. Brain Pathology. 10:2000;113-126.
18. Tsai H.Y., Lin Y.T., Tsai C.H., Chen Y.F. Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice. Journal of Ethnopharmacology. 75:2001;267-271.
19. Zhang X., Wang J.M., Gong W.H., Mukaida N., Young H.A. Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. Journal of Immunology. 166:2001;7104-7111.