Higher risk behaviour and rates of sexually transmitted diseases in Mwanza compared to Uganda may help explain HIV prevention trial outcomes

AIDS

Volumn 17, Issue 18, 2003, Pages 2653-2660

  Orroth, Kate K ^a   Korenromp, Eline L ^b   White, Richard G ^a   Gavyole, Awene ^c   Gray, Ron H ^d   Muhangi, Lawrence ^e   Sewankambo, Nelson K ^f   Quigley, Maria ^a   Wawer, Maria J ^g   Whitworth, James A G ^a,e   Grosskurth, Heiner ^a,e   Habbema, J Dik F ^b   Hayes, Richard J ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c African Medical and Research Foundation Mwanza   (Tanzania)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e UVRI   (Uganda)

^f MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^g Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Africa; Epidemiology; Intervention trials; Sexual behaviour; Sexually transmitted diseases

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; AGE; ARTICLE; CHLAMYDIASIS; CLINICAL TRIAL; CONDOM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; DIAGNOSTIC PROCEDURE; FEMALE; FERTILITY; GONORRHEA; HERPES SIMPLEX VIRUS 2; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MARRIAGE; MIGRATION; MORTALITY; PRIORITY JOURNAL; QUESTIONNAIRE; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE; SEXUAL BEHAVIOR; SEXUALITY; SEXUALLY TRANSMITTED DISEASE; SYPHILIS; TREATMENT OUTCOME; TRICHOMONIASIS; UGANDA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; CONDOMS; FEMALE; GONORRHEA; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; MARITAL STATUS; MIDDLE AGED; PREVALENCE; RISK-TAKING; RURAL HEALTH; SEX DISTRIBUTION; SEXUAL BEHAVIOR; SEXUAL PARTNERS; SEXUALLY TRANSMITTED DISEASES; TANZANIA; TREATMENT OUTCOME; TRICHOMONAS VAGINITIS; UGANDA;

EID: 12144289558     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200312050-00013     Document Type: Article

References (34)

1. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Trans Inf 1999, 75:3-17.
2. Hayes R, Grosskurth H, ka-Gina G. Impact of improved treatment of sexually transmitted disease on HIV infection: Authors' reply. Lancet 1995, 346:1159-1160.
3. Grosskurth H, Mosha F, Todd J, Mwijarubi E, Klokke A, Senkoro K, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomized controlled trial. Lancet 1995, 346:530-536.
4. Wawer MJ, Sewankambo NK, Serwadda D, Quinn TC, Paxton LA, Kiwanuka N, et al. Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Lancet 1999, 353:525-535.
5. Kamali A, Quigley M, Nakiyingi J, Kinsman J, Kengeya-Kayondo J, Gopal R, et al. A community randomised trial of sexual behaviour and syndromic STI management interventions on HIV-1 transmission in rural Uganda. Lancet 2003, 361: 645-652.
6. Hitchcock P, Fransen L. Preventing HIV infection: lessons from Mwanza and Rakai. Lancet 1999, 353:513-515.
7. Grosskurth H, Gray RH, Hayes R, Mabey D, Wawer MJ. Control of sexually transmitted diseases for HIV-1 prevention: understanding the implications of the Mwanza and Rakai trials. Lancet 2000, 355:1981-1987.
8. Boily MC, Lowndes CM, Alary M. Complementary hypothesis concerning the community sexually transmitted disease mass treatment puzzle in Rakai, Uganda. AIDS 2000, 14:2583-2592.
9. Gray RH, Wawer MJ, Sewankambo NK, Serwadda D, Li C, Moulton LH, et al. Relative risks and population attributable fraction of incident HIV associated with STD symptoms and treatable STDs in Rakai District, Uganda. AIDS 1999, 13: 2113-2123.
10. Orroth KK, Gavyole A, Todd J, Mosha F, Ross D, Mwijarubi E, et al. Syndromic treatment of sexually transmitted diseases reduces the proportion of incident HIV infections attributable to these diseases in rural Tanzania. AIDS 2000, 14:1429-1437.
11. Korenromp EL. Treatment of Sexually Transmitted Diseases as an HIV Prevention Strategy? Cofactor Magnitudes, Syndromic Management and a Reappraisal of the Mwanza and Rakai Trials. Department of Public Health. Rotterdam: Erasmus University; 2001. p. 264.
12. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med 2000, 342:921-929.
13. Grosskurth H, Mosha F, Todd J, Senkoro K, Newell J, Klokke A, et al. A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 2. Baseline survey results. AIDS 1995, 9:927-934.
14. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Paxton L, Berkley S, et al. A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda. AIDS 1998, 12:1211-1225.
15. Board of Statistics. 1988 Population Census: National Profile, Fertility and Mortality Data. Dar es Salaam: President's Office, Planning Commission, 1994.
16. Republic of Uganda. 1991 Population and Housing Census, Rakai district. Entebbe: Statistical Division, Ministry of Planning, 1991.
17. Todd J, Balira R, Grosskurth H, Mayaud P, Mosha F, ka-Gina G, et al. HIV-associated adult mortality in a rural Tanzanian population. AIDS 1997, 11:801-807.
18. Nunn AJ, Mulder DW, Kamali A, Ruberantwari A, Kengeya Kayondo JF, Whitworth JAG. Mortality associated with HIV-1 infection over five years in a rural Ugandan population: cohort study. BMJ 1997, 315:767-771.
19. Sewankambo N, Gray RH, Ahmad S, Serwadda D, Wabwire-Mangen F, Nalugoda F, et al. Mortality associated with HIV infection in rural Rakai district Uganda. AIDS 2000, 14: 2391-2400.
20. Quigley M, Munguti K, Grosskurth H, Todd J, Mosha F, Senkoro K, et al. Sexual behaviour patterns and other risk factors for HIV infection in rural Tanzania: a case-control study. AIDS 1997, 11:237-248.
21. Munguti K, Grosskurth H, Newell J, Senkoro K, Mosha F, Todd J, et al. Patterns of sexual behaviour in a rural population in northwestern Tanzania. Soc Sci Med 1997, 44:1553-1561.
22. Orroth KK, Korenromp EL, White RG, Changalucha J, de Vlas SJ, Gray RH, et al. Comparison of STD prevalences in the Mwanza, Rakai and Masaka trial populations: the role of selection bias and diagnostic errors. Sex Trans Inf 2003, 79:98-105.
23. Gray RH, Wawer MJ, Brookmeyer R, Sewankambo N, Serwadda D, Wabwire-Mangen F, et al. Probability of HIV-1 transmission per coital act in monogamous heterosexual, HIV-1 discordant couples in Rakai, Uganda. Lancet 2001, 357:1149-1153.
24. Carpenter LM, Kamali A, Ruberantwari A, Malamba SS, Whitworth JAG. Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV sero-status of the partners. AIDS 1999, 13:1083-1089.
25. Hugonnet S, Mosha F, Todd J, Mugeye K, Klokke A, Ndeki L, et al. Incidence of HIV infection in stable sexual partnerships: a retrospective cohort study of 1802 couples in Mwanza Region, Tanzania. J Acquir Immune Defic Syndr 2002, 30:73-80.
26. Smallman Raynor MR, Cliff AD. Civil war and the spread of AIDS in Central Africa. Epidemiol Infect 1991, 107:69-80.
27. Wawer M, Serwadda D, Gray RH, Sewankambo NK, Li C, Nalugoda F, et al. Trends in HIV-1 prevalence may not reflect trends in incidence in mature epidemics: data from the Rakai population-based cohort, Uganda. AIDS 1997, 11:1023-1030.
28. Korenromp EL, Bakker R, De Vlas SJ, Gray RH, Wawer MJ, Serwadda D, et al. HIV dynamics and behaviour change as determinants of the impact of STD treatment on HIV transmission in the context of the Rakai trial. AIDS 2002, 16: 2209-2218.
29. Konde-Lule JK, Wawer MJ, Sewankambo NK, Serwadda D, Kelly R, Li C, et al. Adolescents, sexual behavior and HIV-1 in rural Rakai district, Uganda. AIDS 1997, 11:791-799.
30. Serwadda D, Wawer MJ, Musgrave SD, Sewankambo NK, Kaplan JE, Gray RH. HIV risk factors in three geographic strata of rural Rakai district, Uganda. AIDS 1992, 6:983-989.
31. Kamali A, Carpenter L, Whitworth J, Pool R, Ruberantwari A, Ojwiya A. Seven-year trends in HIV-1 infection rates, and changes in sexual behaviour, among adults in rural Uganda. AIDS 2000, 14:427-434.
32. Mulder D, Nunn A, Kamali A, Kengeya-Kayondo J. Decreasing HIV-1 seroprevalence in young adults in a rural Ugandan cohort. BMJ 1995, 311:833-836.
33. Malamba SS, Wagner HU, Maude G, Okongo M, Nunn AJ, Kengeya-Kayondo JF, et al. Risk factors for HIV-1 infection in adults in a rural Ugandan community: a case-control study. AIDS 1994, 8:253-257.
34. Kilian AHD, Gregson S, Ndyanabangi B, Walusaga K, Kipp W, Sahlmuller G, et al. Reductions in risk behaviour provide the most consistent explanation for declining HIV-1 prevalence in Uganda. AIDS 1999, 13:391-398.