Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma

Journal of Neuro-Oncology

Volumn 67, Issue 1-2, 2004, Pages 215-220

  Landy, Howard ^a   Markoe, Arnold ^a   Potter, Priscilla ^a   Lasalle, Garrett ^a   Marini, Angela ^b   Savaraj, Niramol ^a   Reis, Isildinha ^b   Heros, Deborah ^a   Wangpaichitr, Medhi ^a   Feun, Lynn ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

Brain tumor; Estramustine; Glioma; Radiosurgery; Radiotherapy

Indexed keywords

ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; ESTRAMUSTINE PHOSPHATE SODIUM; ONDANSETRON; PROCHLORPERAZINE; RADIOSENSITIZING AGENT; STEROID;

ADULT; AGE; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG DOSE REGIMEN; FATIGUE; FEMALE; GAMMA KNIFE RADIOSURGERY; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN TISSUE; MALE; MIXED TUMOR; MULTIMODALITY CANCER THERAPY; MYOPATHY; NAUSEA AND VOMITING; OLIGODENDROGLIOMA; PATIENT SELECTION; PILOT STUDY; RADIATION DOSE; RADIOSENSITIZATION; STEREOTAXIC SURGERY; SURVIVAL TIME; TUMOR RECURRENCE; TUMOR VOLUME;

ADULT; AGED; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; ESTRAMUSTINE; FEMALE; GLIOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS; RADIATION-SENSITIZING AGENTS; RADIOSURGERY; RADIOTHERAPY; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 12144287560     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEON.0000021825.41221.b5     Document Type: Article

References (29)

1. Loeffler JS, Alexander E, Shea WM, Wen PY, Fine HA, Kooy HM, Black PM: Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol 10: 1379-1385, 1992
2. Punzi JS, Duax WL, Strong P, Griffin JF, Flocco MM, Zacharias DE, Carrell HL, Tew KD, Glusker JP: Molecular conformation of estramustine and two analogues. Mol Pharmcol 41: 569-576, 1992
3. Ryu S, Gabel M, Khil MS, Lee YJ, Kim SH, Kim JH: Estramustine: a novel radiation enhancer in human carcinoma cells. Int J Radiat Oncol Biol Phys 30: 99-104, 1994
4. Yoshida D, Piepmeier J, Weinstein M: Estramustine sensitizes human glioblastoma cells to irradiation. Cancer Res 54: 1415-1417, 1994
5. Bergenheim AT, Zackrisson B, Elfverson J, Roos G, Henriksson R: Radiosensitizing effect of estramustine in malignant glioma in vitro and in vivo. J Neuro-Oncol 23: 191-200, 1995
6. Kim JH, Khil MS, Kim SH, Ryu S, Gabel M: Clinical and biological studies of estramustine phosphate as a novel radiation sensitizer. Int J Radiat Oncol Biol Phys 29: 555-557, 1994
7. von Schoultz E, Lundgren E, Henriksson R: Effects of estramustine and its constituents on human malignant glioma cells. Anticancer Res 10: 693-696, 1990
8. von Schoultz E, Gunnarsson PO, Henriksson R: Uptake, metabolism, and antiproliferative effect of estramustine phosphate in human glioma cell lines. Anticancer Res 9: 1713-1716, 1989
9. Yoshida D. Noha M, Watanabe K, Bergenheim T, Henriksson R, Teramoto A: The bleb formation of the extracellular pseudopodia; early evidence of mircotubule depolymerization by estramustine phosphate in glioma cell; in vitro study. J Neuro-Oncol 52: 37-47, 2001
10. von Schoultz E, Bergenheim T, Grankvist K, Henriksson R: Estramustine binding protein in human brain-tumor tissue. J Neurosurg 74: 962-964, 1991
11. Karlsson AE, Bjork P, Bergenheim AT, Sandstrom J, Hedman H, Henriksson R: Estramustine-binding protein in malignant glioma in rat. J Neuro-Oncol 49: 19-26, 2000
12. von Schoultz E, Lundblad D, Bergh J, Grankvist K, Henriksson R: Estramustine binding protein and antiproliferative effect of estramustine in human glioma cell lines. Br J Cancer 58: 326-329, 1988
13. Bergenheim AT, Bjork P, Bergh J, von Schoultz E, Svedherg H, Henriksson R: Estramustine-binding protein and specific binding of the anti-mitotic compound estramustine in astrocytoma. Cancer Res 54: 4974-4979, 1994
14. Bergenheim AT, Gunnarsson PO, Edman K, von Schoultz E, Hariz MI, Henriksson R: Uptake and retention of estramustine and the presence of estramustine binding protein in malignant brain tumours in humans. Br J Cancer 67: 358-361, 1993
15. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5: 649-655, 1982
16. Panda D, Miller HP, Islam K, Wilson L: Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: a possible mechanistic basis of its antitumor action. Proc Natl Acad Sci USA 94: 10560-10564, 1997
17. Johansson M, Bergenheim AT, D'Argy R, Edman K, Gunnarsson PO, Widmark A, Henriksson R: Distribution of estramustine in the BT4C rat glioma model. Cancer Chemother Pharmacol 41: 317-325, 1998
18. Yoshida D, Cornell-Bell A, Piepmeier JM: Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes. Neurosurgery 34: 863-868, 1994
19. Yoshida D, Piepmeier JM, Akira T: In vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate. Neurosurgery 39: 360-366, 1996
20. Yoshida D, Piepmeier JM, Bergenheim T, Henriksson R, Teramoto A: Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent: in vitro study. Br J Cancer 77(1): 21-25, 1998
21. Yoshida D, Hoshino S, Shimura T, Takahashi H, Teramoto A: Drug-induced apoptosis by anti-microtubule agent, estramustine phosphate on human malignant glioma cell line, U87MG; in vitro study. J Neuro-Oncol 47: 133-140, 2000
22. Wang LG, Xiao ML, Kreis W, Budman DR: The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 44: 355-361, 1999
23. Vallbo C, Bergenheim AT, Bergstrom P, Gunnarsson PO, Henriksson R: Apoptotic tumor cell death induced by estramustine in patients with malignant glioma. Clin Cancer Res 4: 87-91, 1998
24. Valbo C, Bergenheim T, Bergh A, Grankvist K, Henriksson R: DNA fragmentation induced by the antimitotic drug estramustine in malignant rat glioma but not in normal brain - suggesting an apoptotic cell death. Br J Cancer 71: 717-720, 1995
25. von Shoultz E, Grankvist K, Gustavsson H, Henriksson R: Effects of estramustine on DNA and cell membrane in malignant glioma cells. Acta Oncol 30: 719-723, 1991
26. Piepmeier JM, Keefe DL, Weinstein MA, Yoshida D, Zielinski J, Lin TT, Zhaochon C, Naftolin F: Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. Neurosurgery 32: 422-431, 1993
27. Kayser-Gatchalian MC, Kayser K: Thrombosis and intracranial tumors. J Neurol 209: 217-224, 1975
28. Hamilton MG, Hull RD, Pineo GF: Prophylaxis of venous thromboembolism in brain tumor patients. J Neuro-Oncol 22: 111-126, 1994
29. Marras LC, Geerts WH, Perry JR: The risk of venous thromboembolism is increased throughout the course of malignant glioma. Cancer 89: 640-646, 2000