Apoptotic tumor cell death induced by estramustine in patients with malignant glioma

Clinical Cancer Research

Volumn 4, Issue 1, 1998, Pages 87-91

  Vallbo, Christina ^a   Bergenheim, A Tommy ^a   Bergström, Per ^a   Gunnarsson, Per Olof ^b   Henriksson, Roger ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b Pharmacia Upjohn   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRAMUSTINE PHOSPHATE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; DNA DAMAGE; DNA DETERMINATION; DRUG CYTOTOXICITY; FEMALE; GAS CHROMATOGRAPHY; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TUMOR CELL DESTRUCTION;

ADULT; AGED; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; DNA FRAGMENTATION; ESTRAMUSTINE; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; RATS;

EID: 0031907499     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. von Schoultz, E., Lundblad, D., Bergh, J., Grankvist, K., and Henriksson, R. Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines. Br. J. Cancer, 58: 326-329, 1988.
2. Piepmeier, J. M., Keefe, D. L., Weinstein, M. A., Yoshida, D., Zielinski, J., Lin, T. T., Chen, Z., and Naftolin, F. Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. Neurosurgery (Baltimore), 32: 422-431, 1993.
3. Bergenheim, A. T., Elfverson, J., Gunnarsson, P-O., Edman, K., Hartman, M., and Henriksson, R. Cytotoxic effect and uptake of estramustine in a rat glioma model. Int. J. Oncol., 5: 293-299, 1994.
4. Dahllöf, B., Billström, A., Cabral, F., and Hartley-Asp, B. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res., 53: 4573-4581, 1993.
5. Bergenheim, A. T., Zackrisson, B., Elfverson, J., Roos, G., and Henriksson, R. Radiosensitizing effect of estramustine in malignant glioma in vitro and in vivo. J. Neuro-oncol., 23: 191-200, 1995.
6. Engström, K. G., Grankvist, K., and Henriksson, R. Early morphological detection of estramustine cytotoxicity measured as alteration in cell size and shape by a new technique of microperifusion. Eur. J. Cancer, 10: 1288-1295, 1991.
7. Sandström, P-E., Jonsson, Ö., Grankvist, K., and Henriksson, R. Identification of potassium flux pathways and their role in the cytotoxicity of estramustine in human malignant glioma, prostatic carcinoma, and pulmonary carcinoma cell lines. Eur. J. Cancer, 30A: 1822-1826, 1994.
8. Henriksson, R., Bjermer, L., von Schoultz, E., and Grankvist, K. The effect of estramustine on microtubule is different from the direct action via oxygen radicals on DNA and cell membrane. Anticancer Res., 10: 303-310, 1990.
9. Vallbo, C., Bergenheim, T., Bergh, A., Grankvist. K., and Henriksson, R. DNA fragmentation induced by the antimitotic drug estramustine in malignant rat glioma but not in normal brain, suggesting an apoptotic cell death. Br. J. Cancer, 71: 717-720, 1995.
10. Gunnarsson, P. O., Andersson, S-B., Johansson, S-Å., Nilsson, C., and Plym-Forsell, G. Pharmacokinetics of estramustine phosphate in prostatic cancer patients. Eur. J. Clin. Pharmacol., 26: 113-119, 1984.
11. Wijsman, J. H., Jonker, R. R., Keijzer, R., Develde, D. J. H., Cornelisse, C. J., and van Dierendonck, J. H. A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA. J. Histochem. Cytochem., 41: 7-12, 1993.
12. English, H. F., Kyprianou, N., and Isaacs, J. T. Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration. Prostate, 15: 233-250, 1989.
13. Dive, C., and Wyllie, A. H. Apoptosis and cancer chemotherapy. In: J. A. Hickman and T. T. Tritton (eds.), Frontiers in Pharmacology: Cancer Chemotherapy, pp. 21-56. Oxford, United Kingdom: Blackwell Scientific, 1993.
14. Tounekti, O., Pron, G., Belehradek, J., Jr., and Mir, L. M. Bleomycin, an apoptosis-mimetic drug that induces two types of cell death, depending on the number of molecules internalized. Cancer Res., 53: 5462-5469, 1993.
15. Andersson, S-B., Gunnarsson P. O., Nilsson T., and Plym-Forsell, G. Metabolism of estramustine phosphate in patients with prostatic carcinoma. Eur. J. Drug Metab. Pharmacokinet., 6: 149-154, 1981.
16. Andersson, S-B., Lundgren, R., and Svensson, L. Gas chromatographic determination of four metabolites of estramustine phosphate in plasma. Acta Pharm. Suec., 19: 1-10, 1982.
17. Isaacs, J. T. Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer. Curr. Opin. Oncol., 6: 82-89, 1994.
18. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119: 493-501, 1992.
19. Gorcyza, W., Gong, J. P., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53: 1945-1951, 1993.
20. von Schoultz, E., Grankvist, K., Gustafsson, H., and Henriksson, R. Effects of estramustine on DNA and cell membrane in malignant glioma cells. Acta Oncol., 30: 719-723, 1991.
21. Gunnarsson, P. O., Davidsson, T., Andersson, S. B., Backman, C., and Johansson, S. Å. Impairment of estramustine phosphate absorption by concurrent milk and food intake. Eur. J. Clin. Pharmacol., 38: 189-193, 1990.
22. Bergenheim, A. T., Gunnarsson, P. O., Edman, K., von-Schoultz, E., Hariz, M. I., and Henriksson, R. Uptake and retention of estramustine and the presence of estramustine binding protein in malignant brain tumors in humans. Br. J. Cancer, 67: 358-361, 1993.
23. Yoshida, D., Cornell-Bell, A., and Piepmeier, J. Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes. Neurosurgery (Baltimore), 34: 863-868, 1994.
24. von Schoultz, E., Bergenheim, A. T., Grankvist, K., and Henriksson, R. Estramustine-binding protein in human brain tumor tissue. J. Neurosurg., 74: 962-964, 1991.
25. Bergenheim, A. T., Björk, P., Bergh, J., von Schoultz, E., Svedberg, H., and Henriksson, R. Estramustine-binding protein and specific binding of the antimitotic compound estramustine in astrocytoma. Cancer Res., 54: 4974-4979, 1994.
26. Noseda, A., White, J. G., Godwin, P. L., Jerome, W. G., and Modest, E. J. Membrane damage in leukemic cells induced by ether and ester lipids: an electron microscopic study. Exp. Mol. Pathol., 1: 69-83, 1989.
27. Noronha-Dutra, A. A., Steen-Dutra, E. M., and Woolf, N. Epinephrine-induced cytotoxicity of rat plasma: its effects on isolated cardiac myocytes. Lab. Invest., 6: 817-823, 1988.
28. Hockenbery, D. M., Oltvai, Z. N., Yin, X-M., Milliman, C. L., and Korsmeyer, S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75: 241-251, 1993.
29. Louis, D. N. The p53 gene and protein in human brain tumors. J. Neuropathol. Exp. Neurol., 53: 11-21, 1994.
30. Danks, R. A., Chopra, G., Gonzales, M. F., Orian, J. M., and Kaye, A. H. Aberrant p53 expression does not correlate with the prognosis in anaplastic astrocytoma. Neurosurgery (Baltimore), 37: 246-254, 1995.
31. Rubio, M. P., von Deimling, A., Yandell, D. W., Wiestler, O. D., Gusella, J. F., and Louis, D. N. Accumulation of wild-type p53 in human astrocytomas. Cancer Res., 53: 3465-3467, 1993.