Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy

Cardiovascular Research

Volumn 59, Issue 3, 2003, Pages 649-657

  Li, Joan ^a,b   Yatani, Atsuko ^a   Kim, Song Jung ^a   Takagi, Gen ^a   Irie, Keiichi ^a   Zhang, Qizhi ^a   Karoor, Vijaya ^a   Hong, Chull ^a   Yang, Guiping ^a   Sadoshima, Junichi ^a   Depre, Christophe ^a   Vatner, Dorothy E ^a   West, Malcolm J ^b   Vatner, Stephen F ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Autonomic nervous system; Calcium (cellular); Contractile function; Hypertrophy; Signal transduction

Indexed keywords

CALCINEURIN; CALCIUM CHANNEL; CALCIUM ION; POTASSIUM ION; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DENSITY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; HEART AFTERLOAD; HEART CONTRACTION; HEART DENERVATION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; INWARDLY RECTIFYING POTASSIUM; MALE; MEASUREMENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; VELOCITY;

ANIMALS; AORTA, ABDOMINAL; AORTIC STENOSIS, SUBVALVULAR; ATRIAL NATRIURETIC FACTOR; AUTONOMIC DENERVATION; AUTONOMIC NERVOUS SYSTEM; CALCINEURIN; CALCIUM SIGNALING; ELECTROPHYSIOLOGY; IMMUNOBLOTTING; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; MYOCARDIUM; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 12144287466     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00471-1     Document Type: Article

References (50)

1. Molkentin J.D., Lu J.R., Antos C.L., et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93:1998;215-228.
2. Sussman M.A., Lim H.W., Gude N., et al. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science. 281:1998;1690-1693.
3. Wilkins B.J., Molkentin J.D. Calcineurin and cardiac hypertrophy: where have we been? Where are we going? J Physiol. 541:2002;1-8.
4. Olson E.N., Molkentin J.D. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circ Res. 84:1999;623-632.
5. Molkentin J.D. Calcineurin and beyond: cardiac hypertrophic signaling. Circ Res. 87:2000;731-738.
6. Sugden P.H. Signaling in myocardial hypertrophy: life after calcineurin? Circ Res. 84:1999;633-646.
7. Bueno O.F., Wilkins B.J., Tymitz K.M., et al. Impaired cardiac hypertrophic response in Calcineurin Abeta-deficient mice. Proc Natl Acad Sci USA. 99:2002;4586-4591.
8. Meguro T., Hong C., Asai K., et al. Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res. 84:1999;735-740.
9. Zhang W., Kowal R.C., Rusnak F., et al. Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. Circ Res. 84:1999;722-728.
10. Ding B., Price R.L., Borg T.K., et al. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. Circ Res. 84:1999;729-734.
11. Soderling T.R. The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem Sci. 24:1999;232-236.
12. Brilla C.G., Pick R., Tan L.B., Janicki J.S., Weber K.T. Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res. 67:1990;1355-1364.
13. Tweedie D., Henderson C.G., Kane K.A. Assessment of subrenal banding of the abdominal aorta as a method of inducing cardiac hypertrophy in the guinea pig. Cardioscience. 6:1995;115-119.
14. Weber K.T., Brilla C.G., Janicki J.S. Signals for the remodeling of the cardiac interstitium in systemic hypertension. J Cardiovasc Pharmacol. 17:1991;S14-19.
15. Iwase M., Bishop S.P., Uechi M., et al. Adverse effects of chronic endogenous sympathetic drive induced by cardiac Gs alpha overexpression. Cirs Res. 78:1996;517-524.
16. Muscará M.N., McKnight W., Lovren F., et al. Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. Am J Physiol. 279:2000;H528-H535.
17. 2+] and work in trabeculae from hypertrophic and normal rat hearts. Cirs Res. 82:1998;1189-1198.
18. Hansson M., Uno Kjörell U., Forsgren S. Increased immunoexpression of atrial natriuretic peptide in the heart conduction system of the rat after cardiac sympathectomy. J Mol Cell Cardiol. 30:1998;2047-2057.
19. Harder K.W., Owen P., Wong L.K., et al. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem J. 298:1994;395-401.
20. Martin B., Pallen C.J., Wang J.H., Graves D.J. Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin. J Biol Chem. 260:1985;14932-14937.
21. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
22. Heid C.A., Stevens J., Livak K.J., Williams P.M. Real time quantitative PCR. Genome Res. 6:1996;986-994.
23. Depre C., Shipley G.L., Chen W., et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med. 4:1998;1269-1275.
24. 2+ channels in mouse ventricular myocytes. Am J Physiol. 272:1997;H606-612.
25. Yatani A., Frank K., Sako H., Kranias E.G., Dorn G.W. 2nd. Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes. J Mol Cell Cardiol. 31:1999;1327-1336.
26. 2+ channel pathways. J Clin Invest. 103:1999;1089-1097.
27. Yatani A., Seidel C.L., Allen J., Brown A.M. Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein. Circ Res. 60:1987;523-533.
28. 2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway. J Mol Cell Cardiol. 33:2001;249-259.
29. McDonald T.F., Pelzer S., Trautwein W., Pelzer D.J. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev. 74:1994;365-507.
30. 2+ current in rabbit ventricular myocytes. Circ Res. 75:1994;854-861.
31. + channels. Cardiovasc Res. 57:2003;320-332.
32. + currents in isolated adult rat ventricular myocytes. J Gen Physiol. 97:1991;973-1011.
33. Lim H.W., De Windt L.J., Steinberg L., et al. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation. 101:2000;2431-2437.
34. Eto Y., Yonekura K., Sonoda M., et al. Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. Circulation. 101:2000;2134-2137.
35. Fu L.W., Pan H.L., Longhurst J.C. Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am J Physiol. 273:1997;H2726-2737.
36. Pan H.L., Zeisse Z.B., Pitsillides K.F., Longhurst J.C. Spatiotemporal aspects of sympathetic C-fiber afferent activity in pressor reflex during abdominal ischemia. Am J Physiol. 272:1997;H1928-1936.
37. Siri F.M. Sympathetic changes during development of cardiac hypertrophy in aortic-constricted rats. Am J Physiol. 255:1988;H452-457.
38. Akers W.S., Cassis L.A. Presynaptic modulation of sympathetic neurotransmission in rat left ventricle slices: effect of pressure overload. J Neural Transm. 107:2000;885-902.
39. 2+ handling in a calcineurin transgenic model of heart failure. Cardiovasc Res. 54:2002;105-116.
40. Petrashevskaya N., Bodi I., Rubio M., Molkentin J., Schwartz A. Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovasc Res. 54:2002;117-132.
41. 2+ response amplitude and duration. Nature. 386:1997;759-760.
42. 2+ oscillations. Science. 279:1998;191-192.
43. Zou Y., Hiroi Y., Uozumi H., et al. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation. 104:2001;97-101.
44. Zou Y., Yao A., Zhu W., et al. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation. 104:2001;102-108.
45. 2+ channels. J Physiol. 484:(Pt 3):1995;583-592.
46. duBell W.H., Gigena M.S., Guatimosim S., et al. Effects of PP1/PP2A inhibitor calyculin A on the E-C coupling cascade in murine ventricular myocytes. Am J Physiol Heart Circ Physiol. 282:2002;H38-48.
47. Klee C.B., Ren H., Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem. 273:1998;13367-13370.
48. Fiedler B., Lohmann S.M., Smolenski A., et al. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci USA. 99:2002;11363-11368.
49. Ritter O., Schuh K., Brede M., et al. AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway. FASEB J. 17:2003;283-285.
50. Shen Y.-T., Pittman T.J., Buie P.S., et al. Functional role of alpha-calcitonin gene-related peptide in the regulation of the cardiovascular system. J Pharmacol Exp Ther. 298:2001;551-558.