Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 8, 2004, Pages 1895-1904

  Drizin, Irene ^a   Altenbach, Robert J ^a   Buckner, Steven A ^a   Whiteaker, Kristi L ^a   Scott, Victoria E ^a   Darbyshire, John F ^a   Jayanti, Venkata ^a   Henry, Rodger F ^a   Coghlan, Michael J ^a   Gopalakrishnan, Murali ^a   Carroll, William A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 [4 (TRIFLUOROMETHOXY)PHENYL] 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 3 (1 METHYL 3,5 DIOXO 3,4,5,6,8,9 HEXAHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDIN 4 YL)BENZONITRILE; 4 (2,1,3 BENZOXADIAZOL 5 YL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (2,1,3 BENZOXADIAZOL 5 YL) 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; 4 (3 BROMO 4 FLUOROPHENYL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (3 BROMO 4 FLUOROPHENYL) 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; 4 (3 BROMO 4 METHYLPHENYL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (3 BROMO 4 METHYLPHENYL) 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; 4 (3,4 DICHLOROPHENYL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (4 CHLORO 3 NITROPHENYL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (4 CHLORO 3 NITROPHENYL) 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; 4 (4 FLUORO 3 IODOPHENYL) 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 (4 FLUORO 3 IODOPHENYL) 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; 4 [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1,2,4,6,7,8 HEXAHYDROCYCLOPENTA[B]PYRAZOLO[4,3 E]PYRIDINE 3,5 DIONE; 4 [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 4,9 DIHYDRO 1H ISOXAZOLO[3,4 B]PYRANO[4,3 E]PYRIDINE 3,5(6H,8H) DIONE; ADENOSINE TRIPHOSPHATE; CYCLOHEXANONE; CYCLOPENTANONE DERIVATIVE; DIHYDROPYRIDINE; DIHYDROPYRIDINE NITROGEN; OXAZOLONE; OXYGEN; POTASSIUM CHANNEL STIMULATING AGENT; PYRAZOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLADDER; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; METABOLISM; NONHUMAN; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; CELLS, CULTURED; GUINEA PIGS; HUMANS; MEMBRANE PROTEINS; OXAZOLONE; POTASSIUM CHANNELS; PYRAZOLES; PYRAZOLONES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

SUS SCROFA;

EID: 12144287141     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.038     Document Type: Article

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