A variant of DNA polymerase β is not cancer specific

Journal of Investigative Surgery

Volumn 17, Issue 6, 2004, Pages 327-331

  Bu, Dawei ^a   Cler, Leslie R ^a   Lewis, Cheryl M ^a   Euhus, David M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Breast cancer; DNA polymerase ; Polymerase 208 236

Indexed keywords

DNA; DNA POLYMERASE; ENZYME VARIANT; MESSENGER RNA;

ARTICLE; BREAST; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DNA BINDING; DNA RECOMBINATION; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; EUKARYOTIC CELL; EXCISION REPAIR; EXON; GENE DELETION; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE; WILD TYPE;

BREAST NEOPLASMS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA POLYMERASE BETA; DNA PRIMERS; DNA REPLICATION; EXONS; FEMALE; HUMANS; MALE; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE DELETION; TESTICULAR NEOPLASMS; VARIATION (GENETICS);

EID: 12144280841     PISSN: 08941939     EISSN: None     Source Type: Journal    
DOI: 10.1080/08941930490524372     Document Type: Article

References (31)

1. Wood RD. DNA repair in eukaryotes. Annu Rev Biochem. 1996;65:135-167.
2. Wang TSF. Eukaryotic DNA polymerases. Annu Rev Biochem. 1991;60:513-552.
3. Wiebauer K, Jiricny J. Mismatch-specific thymine DNA glycosylase and DNA polymerase β mediate the correction of G.T mispairs in nuclear extracts from human cells. Proc Natl Acad Sci USA. 1990;87:5842-5845.
4. Dianov G, Price A, Lindahl T. Generation of single-nucleotide repair patches following excision of uracil residues from DNA. Mol Cell Biol. 1992;12:1605-1612.
5. Hammond RA, McClung JK, Miller MR. Effect of DNA polymerase inhibitors on DNA repair in intact and permeable human fibroblasts: Evidence that DNA polymerase delta and beta are involved in DNA repair synthesis induced by N-methyl-N′-nitro-N nitrosoguanidine. Biochemistry. 1990;29:286-291.
6. Sobol RW, Horton JK, Kuhn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. Requirement of mammalian DNA polymerase β in base-evision repair. Nature (Lond). 1996;379:183-186.
7. Sweasy JB, Loeb LA. Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in E. coli. J Biol Chem. 1992;267:1407-1410.
8. Ali-Osman F, Berger MS, Rairkar A, Stein DE. Enhanced repair of a cisplatin damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerase α and β, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. J Cell Biochem. 1994;54:11-19.
9. Thompon LH, Brookman KW, Jones NJ, Allen SA, Carrano AV. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol Cell Biol. 1990;10:6160-6171.
10. Tebbs RS, Flannery ML, Meneses JJ, Hartmann A, Tucker JD, Thompson LH, Cleaver JE, Pedersen RA. Requirement for the XRCC1 DNA base excision repair gene during early mouse development. Dev Biol. 1999;208:513-529.
11. Ochs K, Sobol RW, Wilson SH, Kaina B. Cell deficient in DNA polymerase β are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res. 1999;59:1544-1551.
12. Mcbride OW, Kozak CA, Wilson SH. Mapping of the gene for DNA polymerase β to mouse chromosome 8. Cytogenet Cell Genet. 1990;53:108-111.
13. Emi M, Fujiwara Y, Nakajima T, Tsuchiya E, Tsuda H, Hirohashi S, Maeda Y, Tsurrta K, Miyaki M, Nakamura Y. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer. Cancer Res. 1992;52:5368-5372.
14. Bova GS, Carter BS, Bussemakers MJG, Emi M, Fujiwara Y, Kyprianou N, Jacobs SC, Robinson JC, Epstein JI, Walsh PC, Isaacs WB. Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer. Cancer Res. 1993;53:3869-3873.
15. Knowles MA, Elder PA, Williamson M, Cairns JP, Shaw ME, Law MG. Allelotype of human bladder cancer. Cancer Res. 1994;54:531-538.
16. Devilee P, Cornelisse CJ. Somatic genetic changes in human breast cancer. Biochim Biophys Acta. 1994; 1198: 113-130.
17. Zmudzka BZ, SenGupta DN, Matsukage A, Cobranchi R, Kumar P, Wilson SH. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc Natl Sci USA. 1986;83:5106-5110.
18. SenGupta DN, Zmudzda BZ, Kumar P, Cobianchi F, Skowronski J, Wilson SH. Sequence of human DNA polymerase β mRNA obtained through cDNA cloning. Biochem Biophys Res Commun. 1986; 136:341-347.
19. Sadakane Y, Meada K, Kuroda Y, Hori K. Identification of mutations in DNA polymerase β mRNAs from patients with Werner syndrome. Biochem Biophys Res Commun. 1994;200:219-225.
20. Bhattacharyya N, Banerjee S. A variant of DNA polymerase β acts as a dominant negative mutant. Proc Natl Acad Sci USA. 1997;94:10324-10329.
21. Bhattacharyya N, Chen HC, Grundfest-Bronia-Towski S, Banerjee S. Alterations of hMSH2 and DNA polymerase β genes in breast carcinomas and fibroadenomas. Biochem Biophys Res Commun. 1999; 259:429-435.
22. Wang L, Banertee S. Mutations in DNA polymerase β occur in breast, prostate and colorectal tumors. Int J Oncol. 1995;6:459-463.
23. Matsuzaki J, Dobashi Y, Miyamoto H, Ikeda I, Fujinami K, Shuin T, Kubota Y. DNA-polymerase-β gene mutations in human bladder cancer. Mol Carcinogen. 1996 15:38-43.
24. Nowak R, Bieganowski P, Konopinski R, Siedlecki JA. Alternative splicing of DNA polymerase β is not tumor-specific. Int J Cancer. 1996;68:199-202.
25. Bhattacharyya N, Chen HC, Comhair S, Erzurum SC, Banerjee S. Variant forms of DNA polymerase β in primary lung carcinomas. DNA Cell Biol. 1999;18:549-554.
26. Chyan YJ, Strauss PR, Wood TG, Wilson SH. Identification of novel mRNA isoform for human DNA polymerase β. DNA Cell Biol. 1996;15:653-659.
27. Wang L, Patel U, Ghosh L, Banerjee S. DNA polymerase β mutations in human colorectal cancer. Cancer Res. 1992;52:4824-4827.
28. Dobashi Y, Shuin T, Tsuruga H, Uemura H, Torigoe S, Kubota Y. DNA polymerase β gene mutation in human prostate cancer. Cancer Res. 1994;54:2827-2829.
29. Chen HC, Bhattacharyya N, Wang L, Recupero JA, Klein AE, Harter LM, Banerjee S. J Cancer Res Clin Oncol. 2000;126:185-190.
30. Thompson TE, Rogan PK, Risinger JI, Taylor JA. Splice variants but not mutations of DNA polymerase β are common in bladder cancer. Cancer Res. 2002;62:3251-3256.
31. Chyan YJ, Ackerman S, Shepherd NS, Mcbridge OW, Widen SG, Wilson SH, Wood TG. The human DNA polymerase-β gene structure. Evidence of alternative splicing in gene expression. Nucleic Acids Res. 1994;22:2719-2725.