2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model [3]

Journal of Investigative Dermatology

Volumn 124, Issue 1, 2005, Pages 275-277

  Geusau, Alexandra ^a   Khorchide, Maya ^a   Mildner, Michael ^a   Pammer, Johannes ^b   Eckhart, Leopold ^a   Tschachler, Erwin ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A;

BIOLOGICAL MODEL; CELL CULTURE; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; LETTER; PARAKERATOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STRATUM CORNEUM; WESTERN BLOTTING;

EID: 11944255359     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23541.x     Document Type: Letter

References (18)

1. Alibardi L, Dockal M, Reinisch C, Tschachler E, Eckhart L: Ultrastructural localization of caspase-14 in human epidermis, Histochem Cytochem, in press.
2. Eckhart L, Declerq W, Ban J, et al: Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation. J Invest Dermatol 115:1148-1151, 2000
3. Gaido KW, Maness SC: Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 127:199-208, 1994
4. Geusau A, Abraham K, Geissler K, Sator MO, Stingl G, Tschachler E: Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: Clinical and laboratory effects. Environ Health Perspect 109:865-869, 2001
5. Geusau A, Tschachler E, Meixner M, et al: Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 354:1266-1267, 1999
6. Koster MI, Roop DR: The role of p63 in development and differentiation of the epidermis. J Dermatol Sci 34:3-9, 2004
7. Langlands K, Down GA, Kealey T: Id Proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 60:5929-5933, 2000
8. Loertscher JA, Lin TM, Peterson EP, Allen-Hoffmann BL: In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes accelerated terminal differentiation in fetal mouse skin. Toxicol Sci 68:465-472, 2002
9. Loertscher JA, Sattler CA, Allen-Hoffmann BL: 2,3,7,8-tetrachlorodibenzo- p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture. Toxicol Appl Pharmacol 175:121-129, 2001
10. Nickoloff BJ, Chaturvedi V, Bacon P, Qin JZ, Denning MF, Diaz MO: Id-1 delays senescence but does not immortalize keratinocytes. J Biol Chem 275:27501-27504, 2000
11. Panteleyev AA, Thiel R, Wanner R, et al: 2,3,7,8-tetrachlorodibenzo-p- dioxin affects keratin 1 and keratin 17 gene expression and differentially induces keratinization in hairless mouse skin. J Invest Dermatol 108:330-335, 1997
12. Ray SS, Swanson HT: Alteration of keratinocyte differentiation and senescence by the tumor promotor dioxin. Toxicol Appl Pharmacol 192:131-145, 2003
13. Rea MA, Phillips MA, Degraffenried LA, Qin Q, Rice RH: Modulation of human epidermal cell response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by epidermal growth factor. Carcinogenesis 19:497-483, 1998
14. Rendl M, Ban J, Mrass P, et al: Caspase-14 expression by epidermal keratin-ocytes is regulated by retinoids in a differentiation-associated manner. J Invest Dermatol 119:1150-1155, 2002
15. Stark HJ, Baur M, Breitkreuz D, Mirancea N, Fusenig NE: Organotypic keratin-ocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation. J Invest Dermatol 112:681-691, 1999
16. Suskind RR: Chloracne, "the hallmark of dioxin intoxication". Scand J Work Environ Health 11:165-171, 1985
17. Tindall JP: Chloracne and chbracnegens. J Am Acad Dermatol 13:539-560, 1985
18. Xu L, Li AP, Kaminski DL, Ruh MF: 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chem Biol Interact 124:173-189, 2000