Immunohistochemical characterisation of the local immune response in azoxymethane-induced colon tumours in the BDIX inbred rat strain

APMIS

Volumn 112, Issue 10, 2004, Pages 698-707

  Kobaek Larsen, Morten ^a   Diederichsen, Axel ^a   Agger, Ralf ^b   Nissen, Inger ^a   Hokland, Marianne ^b   Zeuthen, Jesper ^c   Ritskes Hoitinga, Jelmera ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

Animal models; Anti tumour response; Colorectal cancer; Rats

Indexed keywords

AZOXYMETHANE; EOSIN; HEMATOXYLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; CELL INFILTRATION; COLON CARCINOMA; COLON TUMOR; CONTROLLED STUDY; DENDRITIC CELL; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE; MACROPHAGE; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; STAINING; T LYMPHOCYTE; TISSUE SECTION;

ANIMALS; AZOXYMETHANE; CD8-POSITIVE T-LYMPHOCYTES; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; RATS;

EID: 11944249595     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2004.apm1121008.x     Document Type: Article

References (23)

1. Steele G Jr, Sjogren HO. Cross-reacting tumor-associated antigen (s) among chemically induced rat colon carcinomas. Cancer Res 1974;34:1801-7.
2. Steele G Jr, Harte PJ, Rayner AA, Corson JM, Madara J, Munroe AE, King VP, Wilson RE. The effect of adjuvant immunotherapy on tumor recurrence after segmental resection of carcinogen-induced Wistar/Furth primary bowel adenocarcinomas. J Immunol 1982;128:7-10.
3. Steele G Jr, Sjogren HO. Cell surface antigens in a rat colon cancer model: correlation with inhibition of tumor growth. Surgery 1977;82:164-9.
4. Jass JR, Love SB, Northover JM. A new prognostic classification of rectal cancer. Lancet 1987;1:1303-6.
5. Di Giorgio A, Botti C, Tocchi A, Mingazzini P, Flammia M. The influence of tumor lymphocytic infiltration on long term survival of surgically treated colorectal cancer patients. Int Surg 1992;77:256-60.
6. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998;58:3491-4.
7. Frey AB. Study of immune response to tumors in the rat. Methods 1997;12:173-88.
8. Kobaek-Larsen M, Fenger C, Hansen K, Nissen I, Diederichsen A, Thorup I, den BM, Vach W, Ritskes-Hoitinga M. Comparative study of histopathologic characterization of azoxymethane-induced colon tumors in three inbred rat strains. Comp Med 2002;52:50-7.
9. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988;96:379-94.
10. Kobaek-Larsen M, Fenger C, Ritskes-Hoitinga J. Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats. APMIS 2004;112:319-29.
11. Marquet RL, Westbroek DL, Jeekel J. Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site. Int J Cancer 1984;33:689-92.
12. Thomas C, Nijenhuis AM, Timens W, Kuppen PJ, Daemen T, Scherphof GL. Liver metastasis model of colon cancer in the rat: immunohistochemical characterization. Invasion Metastasis 1993;13:102-12.
13. Hellstrom I, Garrigues HJ, Garrigues U, Hellstrom KE. Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Le(Y)-related cell surface antigens. Cancer Res 1990;50:2183-90.
14. Sjogren HO, Isaksson M, Willner D, Hellstrom I, Hellstrom KE, Trail PA. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats. Cancer Res 1997;57:4530-6.
15. Fernandez-Acenero MJ, Galindo-Gallego M, Sanz J, Aljama A. Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer 2000;88:1544-8.
16. Pretlow TP, Keith EF, Cryar AK, Bartolucci AA, Pitts AM, Pretlow TG 2nd, Kimball PM, Boohaker EA. Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer Res 1983;43:2997-3000.
17. Diederichsen AC, Zeuthen J, Christensen PB, Kristensen T. Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer. Eur J Cancer 1999;35:721-6.
18. Kagamu H, Shu S. Purification of L-selectin(low) cells promotes the generation of highly potent CD4 antitumor effector T lymphocytes. J Immunol 1998;160:3444-52.
19. Diederichsen AC, Hjelmborg JB, Christensen PB, Zeuthen J, Fenger C. Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells. Cancer Immunol Immunother 2003;52:423-8.
20. Chen-Woan M, Delaney CP, Fournier V, Wakizaka Y, Murase N, Fung J, Starzl TE, Demetris AJ. A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX-62. J Immunol Methods 1995;178:157-71.
21. Ward R, Meagher A, Tomlinson I, O'connor T, Norrie M, Wu R, Hawkins N. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut 2001;48:821-9.
22. Smyrk TC, Watson P, Kaul K, Lynch HT. Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer 2001;91:2417-22.
23. Sørensen NM, Kobæk-Larsen M, Bonne A, van Zutphen B, Fenger C, Kristiansen K, Ritskes-Hoitinga M. Analysis of beta-catenin, Ki-ras and microsatellite stability in azoxymethane-induced colon tumors of BDIX/Orl Ico rats. Comp Med 2003;53:504-7.