Synthesis, antitumour activity and structure-activity relationships of 5H-benzo[b]carbazoles

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 819-837

  Asche, Christian ^a   Frank, Walter ^b   Albert, Antje ^b   Kucklaender, Uwe ^b  

^a UNIVERSITÉ JOSEPH FOURIER   (France)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

5H Benzo b carbazoles; Antitumour activity; Quinone methide

Indexed keywords

2 HYDROXY 5 (2 METHOXYBENZYL) 5H BENZO[B]CARBAZOLE 6,11 DIONE; 2 HYDROXY 5 (3 METHYLBENZYL) 5H BENZO[B]CARBAZOLE 6,11 DIONE; 2 HYDROXY 5 (3,5 DIMETHOXYMETHOXYBENZYL) 5H BENZO[B]CARBAZOLE 6,11 DIONE; 5 (2 BENZYLOXYPHENYL) 2 HYDROXY 5H BENZO[B]CARBAZOLE 6,11 DIONE; 5 (2,4 DICHLOROBENZYL) 2 HYDROXY 5H BENZO[B]CARBAZOLE 6,11 DIONE; 5 (4 BENZYLOXYPHENYL) 5H BENZO[B]CARBAZOLE 2,6 DIOL; 5 (4 METHOXYPHENYL) 5H BENZO[B]CARBAZOLE 2,6 DIOL; AMSACRINE; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; CARBAZOLE DERIVATIVE; DNA; ELLIPTICINE DERIVATIVE; HETEROCYCLIC COMPOUND; INDANONE DERIVATIVE; METHYL 2,6 DIHYDROXY 5 (2 METHOXYBENZYL) 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 (2 PHENETHYL) 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 (3 PHENYLPROPYL) 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 (3,5 DIMETHOXYBENZYL) 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 (4 METHOXYBENZYL) 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 2,6 DIHYDROXY 5 PYRIDIN 2 YLMETHYL 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 5 (2 CHLOROBENZYL) 2,6 DIHYDROXY 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 5 (2,4 DICHLOROBENZYL) 2,6 DIHYDROXY 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 5 BENZYL 2 HYDROXY 11 METHYLEN 6 OXO 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 5 BENZYL 2,6 DIHYDROXY 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; METHYL 5 ETHYL 2,6 DIHYDROXY 5H BENZO[B]CARBAZOLE 1 CARBOXYLATE; MITOMYCIN C; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATTLE; CHEMICAL REACTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA BASE; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MELANOMA CELL; REACTION ANALYSIS; SCREENING; STANDARD; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THYMUS; TITRIMETRY; TUMOR CELL LINE; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CATTLE; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11844307200     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.038     Document Type: Article

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