2,4,5-Trisubstituted thiazole building blocks by a novel multi-component reaction

Synlett

Volumn , Issue 1, 2005, Pages 79-82

  Umkehrer, Michael ^a,b   Kolb, Jürgen ^a   Burdack, Christoph ^a   Hiller, Wolfgang ^b  

^a Priaton GmbH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

2,4,5 trisubstituted thiazoles; 3 substituted 3 bromo 2 isocyanoacrylates; Combinatorial chemistry; Multicomponent reaction; One pot synthesis

Indexed keywords

THIAZOLE DERIVATIVE;

ANALYTIC METHOD; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; COLUMN CHROMATOGRAPHY; COMBINATORIAL CHEMISTRY; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTEIN STRUCTURE; REACTION ANALYSIS;

EID: 11844289672     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-836035     Document Type: Article

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33. 4 and concentrated in vacuo. The resulting oil is purified by column chromatography on silica gel (hexane-EtOAc).
34. 3OOC-), 125.94, 127.31, 128.11, 128.70, 129.09, 129.73, 130.27, 137.34 (Cq), 139.27 (Cq), 147.29 (Cq), 162.53 (Cq), 168.86 (CON), 171.83 (COOMe).