Origin of selectivity in the antibody 20F10-catalyzed Yang cyclization

Journal of the American Chemical Society

Volumn 127, Issue 1, 2005, Pages 132-145

  Saphier, Sigal ^a   Hu, Yunfeng ^b   Sinha, Subhash C ^c   Houk, K N ^a   Keinan, Ehud ^a,c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; ENTHALPY; ISOMERS; STEREOCHEMISTRY; SUBSTRATES;

ACTIVATION ENTHALPY; CYCLIZATION PATHWAYS; FRAGMENTATION TRANSITION STATES; SIDE CHAIN RESIDUES;

ANTIBODIES;

ALKANONE; ANTIBODY; ANTIBODY 20F10; HAPTEN; OXETANE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CATALYSIS; CIS ISOMER; CYCLIZATION; ENANTIOSELECTIVITY; ENTHALPY; FRAGMENTATION REACTION; PHOTOREACTIVITY; QUANTUM MECHANICS; REACTION ANALYSIS; STEREOISOMERISM; TRANS ISOMER; YANG CYCLIZATION;

AMINO ACID SEQUENCE; ANTIBODIES, CATALYTIC; BINDING SITES; CYCLIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHERS, CYCLIC; HAPTENS; HEMOCYANIN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOTOCHEMISTRY; QUANTUM THEORY; SERUM ALBUMIN, BOVINE; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 11844281557     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja045419u     Document Type: Article

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