An Efficient Sol - Gel Reactor for Antibody-Catalyzed Transformations

Chemistry of Materials

Volumn 9, Issue 11, 1997, Pages 2258-2260

  Shabat, Doron ^a   Grynszpan, Flavio ^b   Saphier, Sigal ^a   Turniansky, Avner ^c   Avnir, David ^c   Keinan, Ehud ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000736589     PISSN: 08974756     EISSN: None     Source Type: Journal    
DOI: 10.1021/cm970193y     Document Type: Article

References (35)

1. (a) Schultz, P. G.; Lerner, R. A. Science 1995, 269, 1835.
2. (b) Jacobsen, J. R.; Schultz, P. G. Curr. Opinion Struct. Biol. 1995, 5, 818.
3. (c) MacBeath, G.; Hilvert, D. Chem. Biol. 1996, 3, 433.
4. (d) Keinan, E.; Lerner, R. A. Isr. J. Chem. 1996, 36, 113.
5. (a) Janda, K. D.; Ashley, J. A.; Jones, T. M.; McLeod, A.; Scholoeder, D. M.; Weinhouse, M. I. J. Am. Chem. Soc. 1990, 112, 8886.
6. (b) Spitznagel, T. M.; Jakobs, J. W.; Clark, D. S. Enzyme Microb. Technol. 1993, 15, 916.
7. (a) Avnir, D.; Braun, S.; Lev, O.; Ottolenghi, M. Chem. Mater. 1994, 6, 1605.
8. (b) Dave, B. C., Dunn, B. Valentine, J. S.; Zink, J. I. Anal. Chem. 1994, 6, 1120A.
9. (a) Glezer, V.; Lev, O. J. Am. Chem. Soc. 1993, 115, 2533.
10. (b) Reetz, M. T.; Zonta, A.; Simpelkamp, J. Biotechnol. Bioeng. 1996, 49, 527.
11. (c) Braun, S.; Rappoport, S.; Zusman, R.; Shtelzer, S.; Druckman, S.; Avnir, D.; Ottolenghi, M. In Biotechnology: Bridging Research and Applications; Kluwer: Boston, 1991; pp 205.
12. Dosoretz, C.; Armon, R.; Starosvetzky, J.; Rothschild, N. J. Sol-Gel Sci. Technol. 1996, 7, 7.
13. (a) Livage, J.; Roux, C.; Da Costa, J. M.; Desportes, I.; Quinson, J. F. J. Sol-Gel Sci. Technol. 1996, 7, 45.
14. (b) Wang, R.; Narang, U.; Prassad, P. N.; Bright, F. V. Anal. Chem. 1993, 65, 2671.
15. (c) Aharonson, N.; Altstein, M.; Avidan, G.; Avnir, D.; Bronshtein, A.; Lewis, A.; Lieberman, K.; Ottolenghi, M.; Polevaya, Y.; Rottman, C.; Samuel, J.; Shalom, S.; Strinkovski, A.; Turniansky, A. MRS Symp. Proc. 1994, 346, 519.
16. (d) Turniansky, A.; Avnir, D.; Bronshtein, A.; Aharonson, N.; Altstein, M. J. Sol-Gel Sci. Technol. 1996, 7, 135.
17. (e) Zühlke, J.; Knopp, D.; Niessner, R.; Fresenius J. Anal. Chem. 1995, 67, 654.
18. Biochemical Aspects of Sol - Gel Science and Technology; Avnir, D., Braun, S., Eds.; Kluwer Academic Publishers: Boston, 1996.
19. Livage, R. C. R. Acad. Sci. Paris, II 1996, 322, 417.
20. Reymond, J.-L., Janda, K. D., Lerner, R. A. Angew. Chem., Int. Ed. Engl. 1991, 30, 1711.
21. Sinha, S. C., Keinan, E., Raymond, J.-L. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 11910.
22. Shabat, D.; Sinha, S. C.; Reymond, J.-L.; Keinan, E. Angew. Chem., Int. Ed. Engl. 1996, 35, 2628.
23. Sinha, S. C.; Keinan, E.; Reymond, J.-L. J. Am. Chem. Soc. 1993, 115, 4893.
24. (a) Reymond, J.-L.; Lerner, R. A. J. Am. Chem. Soc. 1992, 114, 2257.
25. (b) Reymond, J.-L.; Jahangiri, G. K.; Stoudt, C.; Lerner, R. A. J. Am. Chem. Soc. 1993, 115, 3909.
26. Shabat, D., Itzhaky, H., Reymond, J.-L., Keinan, E. Nature 1995, 374, 143.
27. Reymond, J.-L.; Reber, J.-L.; Lerner, R. A. Angew. Chem., Int. Ed. Engl. 1994, 33, 475.
28. (a) Sinha, S. C.; Keinan, E. J. Am. Chem. Soc. 1995, 117, 3653.
29. (b) Sinha, S. C.; Keinan, E. Isr. J. Chem. 1996, 36, 185.
30. Avnir, D.; Kaufman, V. R. J. Non-Cryst. Solids 1987, 192, 181.
31. Brawn, S.; Rappoport, S.; Zusman, R.; Avnir, D.; Ottolenghi, M. Mater. Lett. 1990, 10, 1.
32. Janda, K. D.; Bencovic, S. J.; Lerner, R. A. Science 1989, 244, 437.
33. All reactions were carried out at 24 °C and monitored at 254 nm by RP-HPLC (Hitachi L-6200A equipped with a Spherisorb column (25 cm × 4.6 mm, C18, 5 μm) using a mixture of two solutions: (A) acetonitrile:water (3:2) (B) water:trifluoroacetic acid (99.5:0.5) at 0.8 mL/min. The A:B ratio varied between 40:60 and 95:5 throughout the analysis.
34. After periods of 24 h the gradual sealing of the sinter glass filter on the column could be perceived on the decrease of the flow rate. This problem could be easily overcame by the homogeneous blending of the gel within the column and the change in the flow direction when necessary. After proper reequilibration, these physical interventions had no influence on the catalytic behavior of the system.
35. Smigol, V.; Svec, F.; Fréchet, J. M. J. Macromolecules 1993, 26, 5615.